Hydrodynamic Effects of Compliance Mismatch in Stented Arteries

2011 ◽  
Vol 133 (2) ◽  
Author(s):  
N. K. C. Selvarasu ◽  
Danesh K. Tafti ◽  
Pavlos P. Vlachos
Keyword(s):  
Elastic Modulus ◽  
Coronary Artery ◽  
Pressure Gradient ◽  
Treatment Options ◽  
Three Dimensional ◽  
Shear Stresses ◽  
Local Pressure ◽  
Wall Shear ◽  
Vorticity Flux ◽  
Compliance Mismatch

Cardiovascular diseases are the number one cause of death in the world, making the understanding of hemodynamics and development of treatment options imperative. The most common modality for treatment of occlusive coronary artery diseases is the use of stents. Stent design profoundly influences the postprocedural hemodynamic and solid mechanical environment of the stented artery. However, despite their wide acceptance, the incidence of stent late restenosis is still high (Zwart et al., 2010, “Coronary Stent Thrombosis in the Current Era: Challenges and Opportunities for Treatment,” Current Treatment Options in Cardiovascular Medicine, 12(1), pp. 46–57), and it is most prevailing at the proximal and distal ends of the stent. In this work, we focus our investigation on the localized hemodynamic effects of compliance mismatch due to the presence of a stent in an artery. The compliance mismatch in a stented artery is maximized at the proximal and distal ends of the stent. Hence, it is our objective to understand and reveal the mechanism by which changes in compliance contribute to the generation of nonphysiological wall shear stress (WSS). Such adverse hemodynamic conditions could have an effect on the onset of restenosis. Three-dimensional, spatiotemporally resolved computational fluid dynamics simulations of pulsatile flow with fluid-structure interaction were carried out for a simplified coronary artery with physiologically relevant flow parameters. A model with uniform elastic modulus is used as the baseline control case. In order to study the effect of compliance variation on local hemodynamics, this baseline model is compared with models where the elastic modulus was increased by two-, five-, and tenfold in the middle of the vessel. The simulations provided detailed information regarding the recirculation zone dynamics formed during flow reversals. The results suggest that discontinuities in compliance cause critical changes in local hemodynamics, namely, altering the local pressure and velocity gradients. The change in pressure gradient at the discontinuity was as high as 90%. The corresponding changes in WSS and oscillatory shear index calculated were 9% and 15%, respectively. We demonstrate that these changes are attributed to the physical mechanism associating the pressure gradient discontinuities to the production of vorticity (vorticity flux) due to the presence of the stent. The pressure gradient discontinuities and augmented vorticity flux are affecting the wall shear stresses. As a result, this work reveals how compliance variations act to modify the near wall hemodynamics of stented arteries.

Investigation of the Effects of Dynamic Change in Curvature and Torsion on Pulsatile Flow in a Helical Tube

2012 ◽  
Vol 134 (7) ◽  
Author(s):  
N. K. C. Selvarasu ◽  
Danesh K. Tafti
Keyword(s):  
Shear Stress ◽  
Coronary Artery ◽  
Wall Shear Stress ◽  
Secondary Flow ◽  
Pulsatile Flow ◽  
Flow Patterns ◽  
Shear Stresses ◽  
Wall Shear ◽  
Vorticity Flux ◽  
Curvature And Torsion

Cardiovascular diseases are the number one cause of death in the world, making the understanding of hemodynamics and the development of treatment options imperative. The effect of motion of the coronary artery due to the motion of the myocardium is not extensively studied. In this work, we focus our investigation on the localized hemodynamic effects of dynamic changes in curvature and torsion. It is our objective to understand and reveal the mechanism by which changes in curvature and torsion contribute towards the observed wall shear stress distribution. Such adverse hemodynamic conditions could have an effect on circumferential intimal thickening. Three-dimensional spatiotemporally resolved computational fluid dynamics (CFD) simulations of pulsatile flow with moving wall boundaries were carried out for a simplified coronary artery with physiologically relevant flow parameters. A model with stationary walls is used as the baseline control case. In order to study the effect of curvature and torsion variation on local hemodynamics, this baseline model is compared to models where the curvature, torsion, and both curvature and torsion change. The simulations provided detailed information regarding the secondary flow dynamics. The results suggest that changes in curvature and torsion cause critical changes in local hemodynamics, namely, altering the local pressure and velocity gradients and secondary flow patterns. The wall shear stress (WSS) varies by a maximum of 22% when the curvature changes, by 3% when the torsion changes, and by 26% when both the curvature and torsion change. The oscillatory shear stress (OSI) varies by a maximum of 24% when the curvature changes, by 4% when the torsion changes, and by 28% when both the curvature and torsion change. We demonstrate that these changes are attributed to the physical mechanism associating the secondary flow patterns to the production of vorticity (vorticity flux) due to the wall movement. The secondary flow patterns and augmented vorticity flux affect the wall shear stresses. As a result, this work reveals how changes in curvature and torsion act to modify the near wall hemodynamics of arteries.

Effects of Elastic Modulus Change in Helical Tubes Under the Influence of Dynamic Changes in Curvature and Torsion

2014 ◽  
Vol 136 (8) ◽  
Author(s):  
N. K. C. Selvarasu ◽  
Danesh K. Tafti
Keyword(s):  
Elastic Modulus ◽  
Secondary Flow ◽  
Dynamic Change ◽  
Three Dimensional ◽  
Flow Patterns ◽  
Local Pressure ◽  
Moving Wall ◽  
Vorticity Flux ◽  
Late Restenosis ◽  
Curvature And Torsion

The incidence of stent late restenosis is high (Zwart et al., 2010, “Coronary Stent Thrombosis in the Current Era: Challenges and Opportunities for Treatment,” Curr. Treat. Options Cardiovasc. Med., 12(1), pp. 46–57) despite the extensive use of stents, and is most prevalent at the proximal and distal ends of the stent. Elastic modulus change in stented coronary arteries subject to the motion of the myocardium is not studied extensively. It is our objective to understand and reveal the mechanism by which changes in elastic modulus and geometry contribute to the generation of nonphysiological wall shear stress (WSS). Such adverse hemodynamic conditions could have an effect on the onset of restenosis. Three-dimensional (3D), spatiotemporally resolved computational fluid dynamics (CFD) simulations of pulsatile flow with moving wall boundaries and fluid structure interaction (FSI) were carried out for a helical artery with physiologically relevant flow parameters. To study the effect of coronary artery (CA) geometry change on stent elastic modulus mismatch, models where the curvature, torsion and both curvature and torsion change were examined. The elastic modulus is increased by a factor of two, five, and ten in the stented section for all three modes of motion. The changes in elastic modulus and arterial geometry cause critical variations in the local pressure and velocity gradients and secondary flow patterns. The pressure gradient change is  47%, with respect to the unstented baseline when the elastic modulus is increased to 10. The corresponding WSS change is 15.4%. We demonstrate that these changes are attributed to the production of vorticity (vorticity flux) caused by the wall movement and elastic modulus discontinuity. The changes in curvature dominate torsion changes in terms of the effects to local hemodynamics. The elastic modulus discontinuities along with the dynamic change in geometry affected the secondary flow patterns and vorticity flux, which in turn affects the WSS.

scholarly journals Numerical Simulation of Dispersed Particle-Blood Flow in the Stenosed Coronary Arteries

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Mongkol Kaewbumrung ◽  
Somsak Orankitjaroen ◽  
Pichit Boonkrong ◽  
Buraskorn Nuntadilok ◽  
Benchawan Wiwatanapataphee
Keyword(s):  
Numerical Simulation ◽  
Blood Flow ◽  
Shear Stress ◽  
Coronary Artery ◽  
Pressure Drop ◽  
Wall Shear Stress ◽  
Stokes Equations ◽  
Spherical Shape ◽  
Shear Stresses ◽  
Wall Shear

A mathematical model of dispersed bioparticle-blood flow through the stenosed coronary artery under the pulsatile boundary conditions is proposed. Blood is assumed to be an incompressible non-Newtonian fluid and its flow is considered as turbulence described by the Reynolds-averaged Navier-Stokes equations. Bioparticles are assumed to be spherical shape with the same density as blood, and their translation and rotational motions are governed by Newtonian equations. Impact of particle movement on the blood velocity, the pressure distribution, and the wall shear stress distribution in three different severity degrees of stenosis including 25%, 50%, and 75% are investigated through the numerical simulation using ANSYS 18.2. Increasing degree of stenosis severity results in higher values of the pressure drop and wall shear stresses. The higher level of bioparticle motion directly varies with the pressure drop and wall shear stress. The area of coronary artery with higher density of bioparticles also presents the higher wall shear stress.

An Experimental Study of Three-Dimensional Turbulent Boundary Layer and Turbulence Characteristics Inside a Turbomachinery Rotor Passage

1978 ◽  
Vol 100 (4) ◽  
pp. 676-687 ◽  
Author(s):  
A. K. Anand ◽  
B. Lakshminarayana
Keyword(s):  
Boundary Layer ◽  
Pressure Gradient ◽  
Turbulence Intensity ◽  
Three Dimensional ◽  
Stream Line ◽  
Shear Stresses ◽  
Axial Pressure ◽  
Mean Velocity ◽  
Large Defect ◽  
Axial Pressure Gradient

Three-dimensional boundary layer and turbulence measurements of flow inside a rotating helical channel of a turbomachinery rotor are described. The rotor is a four-bladed axial flow inducer operated at large axial pressure gradient. The mean velocity profiles, turbulence intensities and shear stresses, and limiting stream-line angles are measured at various radial and chordwise locations, using rotating triaxial hot-wire and conventional probes. The radial flows in the rotor channel are found to be higher compared to those at zero or small axial pressure gradient. The radial component of turbulence intensity is found to be higher than the streamwise component due to the effect of rotation. Flow near the annulus wall is found to be highly complex due to the interaction of the blade boundary layers and the annulus wall resulting in an appreciable radial inward flow, and a large defect in the mainstream velocity. Increased level of turbulence intensity and shear stresses near the midpassage are also observed near this radial location.

Three-Dimensional Numerical Simulation of the Fluid Dynamics in a Coronary Stent

2009 ◽  
Author(s):  
F. Gori ◽  
A. Boghi ◽  
M. Amitrano
Keyword(s):  
Fluid Dynamic ◽  
Three Dimensional ◽  
Coronary Stent ◽  
Shear Stresses ◽  
Unsteady State ◽  
Hemodynamic Variables ◽  
Stent Geometry ◽  
Severe Coronary Artery ◽  
Wall Shear ◽  
Artery Disease

Stents are commonly used to restore blood flow in patients with severe coronary artery disease. Local hemodynamic variables, as wall shear stress, have an important role in the restenosis and their distribution depends on the stent geometry. The objective of the present study is to carry out CFD simulations in a realistic 3D geometry of a coronary stent in physiological conditions. A comparison is performed between two reconstructed stents, made of 12 rings and similar to the real coronary ones, which differ by the position of the struts, where the first type is with closed cells and the second one with open cells. The artery is modeled as a cylinder with rigid walls and the blood is assumed as incompressible Newtonian fluid in laminar flow with constant physical properties. The commercial computational fluid dynamic code FLUENT is used with a mesh composed of non uniform tetrahedrons. The simulations are performed in steady and unsteady state. Wall shear stresses, WSS, as well as its time variations, are investigated in unsteady state with the conclusion that the stent with closed cells have a better fluid dynamic behavior.

scholarly journals The Influence of Non-Newtonian Model on Properties of Blood Flow Through a Left Coronary Artery with Presence of Different Double Stenosis

2021 ◽  
Vol 39 (3) ◽  
pp. 895-905
Author(s):  
Saleem K. Kadhim ◽  
Mohammed G. Al-Azawy ◽  
Sinan Abdul-Ghafar Ali ◽  
Mina Qays Kadhim
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Left Coronary Artery ◽  
Calculated Data ◽  
Shear Stresses ◽  
Numerical Investigations ◽  
Newtonian Model ◽  
Flow Through ◽  
Wall Shear ◽  
Flow States

Cardiovascular diseases were the main cause for loosing lives in the last decades due to the restricted blood flow states in the blood vessels areas. Numerical investigations have been conducted as the aim of this work to examine the blood flow, and wall shear stresses adjacent to the mono stenosis up to different degrees involved in the main, side and distal main branches as well as observe the pulsatile flow of blood in the left coronary artery through various percentage of stenosis. Both the Carreau non-Newtonian rheological model and the Newtonian model were utilized to model the blood fluid and wall shear stresses of left coronary artery, in a row, all the calculated data were validated with the previously published papers. It was found that the blood flow inside areas of the artery lie within the range of non-Newtonian rheological effects can be present, verifying the need to treat blood as non-Newtonian fluid; especially, with the case of 90% blockage.

scholarly journals A numerical study of strained three-dimensional wall-bounded turbulence

2000 ◽  
Vol 416 ◽  
pp. 75-116 ◽  
Author(s):  
G. N. COLEMAN ◽  
J. KIM ◽  
P. R. SPALART
Keyword(s):  
Pressure Gradient ◽  
Boundary Layers ◽  
Numerical Study ◽  
Three Dimensional ◽  
Adverse Pressure Gradient ◽  
Model Testing ◽  
Turbulent Shear ◽  
Shear Stresses ◽  
Dimensional Boundary ◽  
The Mean

Channel flow, initially fully developed and two-dimensional, is subjected to mean strains that emulate the effect of rapid changes of streamwise and spanwise pressure gradients in three-dimensional boundary layers, ducts, or diffusers. As in previous studies of homogeneous turbulence, this is done by deforming the domain of a direct numerical simulation (DNS); here however the domain is periodic in only two directions and contains parallel walls. The velocity difference between the inner and outer layers is controlled by accelerating the channel walls in their own plane, as in earlier studies of three-dimensional channel flows. By simultaneously moving the walls and straining the domain we duplicate both the inner and outer regions of the spatially developing case. The results are used to address basic physics and modelling issues. Flows subject to impulsive mean three-dimensionality with and without the mean deceleration of an adverse pressure gradient (APG) are considered: strains imitating swept-wing and pure skewing (sideways turning) three-dimensional boundary layers are imposed. The APG influences the structure of the turbulence, measured for example by the ratio of shear stress to kinetic energy, much more than does the pure skewing. For both deformations, the evolution of the Reynolds stress is profoundly affected by changes to the velocity–pressure-gradient correlation Πij. This term – which represents the finite time required for the mean strain to modify the shape and orientation of the turbulent motions – is primarily responsible for the difference (lag) in direction between the mean shear and the turbulent shear stresses, a well-known feature of perturbed three-dimensional boundary layers. Files containing the DNS database and model-testing software are available from the authors for distribution, as tools for future closure-model testing.

Unsteady and Three-Dimensional Simulation of Blood Flow in the Human Aortic Arch

2002 ◽  
Vol 124 (4) ◽  
pp. 378-387 ◽  
Author(s):  
N. Shahcheraghi ◽  
H. A. Dwyer ◽  
A. Y. Cheer ◽  
A. I. Barakat ◽  
T. Rutaganira
Keyword(s):  
Blood Flow ◽  
Aortic Arch ◽  
Thoracic Aorta ◽  
Aortic Wall ◽  
Three Dimensional ◽  
Outer Wall ◽  
Human Aorta ◽  
Shear Stresses ◽  
Descending Thoracic Aorta ◽  
Wall Shear

A three-dimensional and pulsatile blood flow in a human aortic arch and its three major branches has been studied numerically for a peak Reynolds number of 2500 and a frequency (or Womersley) parameter of 10. The simulation geometry was derived from the three-dimensional reconstruction of a series of two-dimensional slices obtained in vivo using CAT scan imaging on a human aorta. The numerical simulations were obtained using a projection method, and a finite-volume formulation of the Navier-Stokes equations was used on a system of overset grids. Our results demonstrate that the primary flow velocity is skewed towards the inner aortic wall in the ascending aorta, but this skewness shifts to the outer wall in the descending thoracic aorta. Within the arch branches, the flow velocities were skewed to the distal walls with flow reversal along the proximal walls. Extensive secondary flow motion was observed in the aorta, and the structure of these secondary flows was influenced considerably by the presence of the branches. Within the aorta, wall shear stresses were highly dynamic, but were generally high along the outer wall in the vicinity of the branches and low along the inner wall, particularly in the descending thoracic aorta. Within the branches, the shear stresses were considerably higher along the distal walls than along the proximal walls. Wall pressure was low along the inner aortic wall and high around the branches and along the outer wall in the ascending thoracic aorta. Comparison of our numerical results with the localization of early atherosclerotic lesions broadly suggests preferential development of these lesions in regions of extrema (either maxima or minima) in wall shear stress and pressure.

scholarly journals Efficient investigation on fully developed flow in a mildly curved 180° open-channel

2014 ◽  
Vol 16 (6) ◽  
pp. 1250-1264 ◽  
Author(s):  
Yuchuan Bai ◽  
Xiaolong Song ◽  
Shuxian Gao
Keyword(s):  
Secondary Flow ◽  
Flow Pattern ◽  
Turbulent Flows ◽  
Three Dimensional ◽  
Engineering Application ◽  
Experimental Investigations ◽  
Shear Stresses ◽  
Fully Developed Flow ◽  
Wall Shear ◽  
Volume Method

Turbulent flow in meandering open channels is one of the most complicated and unpredictable turbulent flows as the interaction of various forces, such as pressure gradient, centrifugal force, and wall shear stresses severely affect the flow pattern. In order to improve significance in engineering application, understanding the overall flow characteristic is the focus. This paper presents the results of numerical and experimental investigations of flow in a 180° mild bend, which is close to criticality with curvature ratio R/B = 3. Considering the characteristic of various models, three-dimensional (3D) re-normalization group (RNG) k–ε model was adopted to simulate the flow efficiently. Governing equations of the flow were solved with a finite-volume method. The pressure-based coupled algorithm was used to compute the pressure. The flow velocities were measured experimentally with Micro acoustic Doppler velocimeter. Good agreement between the numerical results and measurements indicated that RNG k–ε model can successfully predict this flow phenomenon. The flow pattern in this bend is influenced widely by the secondary flow. The variations of velocity components, streamlines, secondary flow, and wall shear stresses are analysed in the study. Some newly discovered phenomenon in this special state are worth noting.

Sign in / Sign up

Export Citation Format

Share Document