scholarly journals New Retinas for Old

2003 ◽  
Vol 125 (10) ◽  
pp. 42-46 ◽  
Author(s):  
Gayle Ehrenman

This article reviews retinal prosthesis that is a seeing-eye chip with as many as 1000 tiny electrodes to be implanted in the eye. It has the potential to help people who have lost their sight regain enough vision to function independently in the sighted world. The Artificial Retina Project is a collaboration of five US National laboratories, three universities, and the private sector. The interface module and the antenna for future versions of the retinal prosthesis will all be implanted in the eye, instead of outside the eye. The retinal prosthesis will help patients who still have neutral wiring from the eye to the brain. One of the challenges in developing the device is creating a microelectrode array that conforms to the curved shape of the retina, without damaging the delicate retinal tissue. Oak Ridge National Laboratory in Oak Ridge, Tennessee, is the lead lab on the Artificial Retina Project. They're the folks responsible for fabricating and testing the electrodes, and making sure they're up to the challenge of being implanted long term in a human body.

Author(s):  
Wendy J. Matthews ◽  
Karren L. More ◽  
Larry R. Walker

Haynes alloy HR-120 (Haynes and HR-120 are trademarks of Haynes International, Inc.) forms a protective oxide scale when exposed to the harsh operating environment of a microturbine primary surface recuperator. Primary surface recuperators manufactured from HR-120 are currently in use on the Capstone C65 MicroTurbine (MicroTurbine is a registered trademark of Capstone Turbine Corporation). Long-term microturbine tests of this alloy are currently being conducted at an elevated turbine exit temperature (∼100°F higher than that in a normal operation) at Capstone Turbine Corporation. Alloy samples that have been tested under steady-state microturbine operating conditions are removed after predetermined exposure intervals for characterization by Capstone Turbine Corporation in collaboration with Oak Ridge National Laboratory. Such evaluations include the characterization of surface oxide scales and the associated alloy compositional changes following a steady-state operation ranging from 1800 h to 14,500 h. Results from the microstructural and compositional analyses of these long-term steady-state engine-tested HR-120 samples are used to illustrate the progression of alloy oxidation in the microturbine operating environment.


Author(s):  
Wendy J. Matthews ◽  
Karren L. More ◽  
Larry R. Walker

The Capstone C65 MicroTurbine Primary Surface Recuperator (PSR) core has been manufactured from Haynes alloy HR-120 since 2005. When exposed to the harsh operating environment of the microturbine PSR, HR-120 forms a protective oxide scale that is resistant to the effects of the water vapor present in the exhaust gas. Long-term accelerated microturbine testing, with samples in a modified PSR with a removable aft dome, is on-going at an elevated Turbine Exit Temperature (TET) ∼100°F higher than normal operation. The elevated TET test engine is operated at steady state conditions and the engine is shut down at pre-determined intervals for sample removal. Material characterization of the elevated TET samples has been carried out by Capstone Turbine Corporation in collaboration with Oak Ridge National Laboratory. The surface oxide scale formation and associated alloy compositional changes have been evaluated for elevated TET samples with operating lives ranging from ∼1,800 – ∼26,500 hours. In addition, field operated HR-120 recuperators have been sectioned and samples have been evaluated for operating lives ranging from ∼5,500 – ∼18,000 hours. Results from the microstructural and compositional analyses of both the long-term steady-state elevated TET HR-120 samples, and the field operated HR-120 recuperator samples, will be presented and compared.


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Toshihiko Matsuo ◽  
Tetsuya Uchida

We have developed the world's first novel type of artificial retina, OUReP (Okayama University Retinal Prosthesis), in which a photoelectric dye that converts light energy into electric potential is covalently bonded to the surface of a polyethylene thin film as an insulator. The receptor that absorbs light and the output device that generates displacement current to stimulate nearby neurons are integrated in a sheet of thin film. It has become possible to measure the surface potential of the artificial retina OUReP using a Kelvin probe that measures the surface potential of semiconductors. When light is turned on and off to the artificial retina OUReP, the surface potential changes rapidly. As the light intensity is increased, the potential change on the surface of the artificial retina becomes larger. As for safety, the artificial retina OUReP was not toxic in all tests for biological evaluation of medical devices. As for efficacy, the artificial retina OUReP was implanted under the retina by vitreous surgery in monkey eyes which had chemically-induced macular degeneration with photoreceptor cell loss. Over the next 6 months, retinal detachment did not occur during the course, and the artificial retina was in contact with the retinal tissue. The amplitude of the visual evoked potential attenuated by macular degeneration recovered 1 month after implantation of the artificial retina, and the recovery of amplitude was maintained until 6 months after the implantation. By using multielectrode array-mounted dish recording system, it has been proved that action potential spikes are induced when the artificial retina is placed on degenerative retinal tissue of retinal dystrophic rats or mice and exposed to light, which is used as an index of the effectiveness of the artificial retina. We have established manufacturing and quality control of the device in a clean room facility, proved the safety and efficacy, and are preparing for first-in-human investigator-initiated clinical trials.


2010 ◽  
Vol 133 (4) ◽  
Author(s):  
Wendy J. Matthews ◽  
Karren L. More ◽  
Larry R. Walker

The Capstone C65 Microturbine primary surface recuperator (PSR) core has been manufactured from Haynes alloy HR-120 since 2005 (Microturbine is a registered trademark of Capstone Turbine Corporation; Haynes and HR-120 are trademarks of Haynes International, Inc.). When exposed to the harsh operating environment of the microturbine PSR, HR-120 forms a protective oxide scale that is resistant to the effects of the water vapor present in the exhaust gas. Long-term accelerated microturbine testing with samples in a modified PSR with a removable aft dome is ongoing at an elevated turbine exit temperature (TET) ∼100°F higher than normal operation. The elevated TET test engine is operated at steady-state conditions, and the engine is shut down at predetermined intervals for sample removal. Material characterization of the elevated TET samples has been carried out by Capstone Turbine Corporation in collaboration with Oak Ridge National Laboratory. The surface oxide scale formation and associated alloy compositional changes have been evaluated for elevated TET samples with operating lives ranging from ∼1800 h to ∼26,500 h. In addition, field-operated HR-120 recuperators have been sectioned and samples have been evaluated for operating lives ranging from ∼5500 h to ∼18,000 h. Results from the microstructural and compositional analyses of both the long-term steady-state elevated TET HR-120 samples and the field-operated HR-120 recuperator samples will be presented and compared.


Author(s):  
Wendy J. Matthews ◽  
Karren L. More ◽  
Larry R. Walker

Haynes Alloy HR-120 forms a protective oxide scale when exposed to the harsh operating environment of a microturbine primary surface recuperator. Primary surface recuperators manufactured from HR-120 are currently in use on the Capstone C65 MicroTurbine. Long-term microturbine tests of this alloy are currently being conducted at an elevated turbine exit temperature (∼100F° higher than normal operation) at Capstone Turbine Corporation. Alloy samples that have been tested under steady-state microturbine operating conditions are removed after pre-determined exposure intervals for characterization by Capstone Turbine Corporation in collaboration with Oak Ridge National Laboratory. Such evaluations include characterization of surface oxide scales and the associated alloy compositional changes following steady-state operation ranging from 1,800 – 14,500 hours. Results from the microstructural and compositional analyses of these long-term, steady-state engine-tested HR-120 samples are used to illustrate the progression of alloy oxidation in the microturbine operating environment.


Author(s):  
N. D. Evans ◽  
M. K. Kundmann

Post-column energy-filtered transmission electron microscopy (EFTEM) is inherently challenging as it requires the researcher to setup, align, and control both the microscope and the energy-filter. The software behind an EFTEM system is therefore critical to efficient, day-to-day application of this technique. This is particularly the case in a multiple-user environment such as at the Shared Research Equipment (SHaRE) User Facility at Oak Ridge National Laboratory. Here, visiting researchers, who may oe unfamiliar with the details of EFTEM, need to accomplish as much as possible in a relatively short period of time.We describe here our work in extending the base software of a commercially available EFTEM system in order to automate and streamline particular EFTEM tasks. The EFTEM system used is a Philips CM30 fitted with a Gatan Imaging Filter (GIF). The base software supplied with this system consists primarily of two Macintosh programs and a collection of add-ons (plug-ins) which provide instrument control, imaging, and data analysis facilities needed to perform EFTEM.


2010 ◽  
Vol 24 (4) ◽  
pp. 249-252 ◽  
Author(s):  
Márk Molnár ◽  
Roland Boha ◽  
Balázs Czigler ◽  
Zsófia Anna Gaál

This review surveys relevant and recent data of the pertinent literature regarding the acute effect of alcohol on various kinds of memory processes with special emphasis on working memory. The characteristics of different types of long-term memory (LTM) and short-term memory (STM) processes are summarized with an attempt to relate these to various structures in the brain. LTM is typically impaired by chronic alcohol intake but according to some data a single dose of ethanol may have long lasting effects if administered at a critically important age. The most commonly seen deleterious acute effect of alcohol to STM appears following large doses of ethanol in conditions of “binge drinking” causing the “blackout” phenomenon. However, with the application of various techniques and well-structured behavioral paradigms it is possible to detect, albeit occasionally, subtle changes of cognitive processes even as a result of a low dose of alcohol. These data may be important for the consideration of legal consequences of low-dose ethanol intake in conditions such as driving, etc.


Author(s):  
Peter R. Breggin

BACKGROUND: The vaccine/autism controversy has caused vast scientific and public confusion, and it has set back research and education into genuine vaccine-induced neurological disorders. The great strawman of autism has been so emphasized by the vaccine industry that it, and it alone, often appears in authoritative discussions of adverse effects of the MMR and other vaccines. By dismissing the chimerical vaccine/autism controversy, vaccine defenders often dismiss all genuinely neurological aftereffects of the MMR (measles, mumps, and rubella) and other vaccines, including well-documented events, such as relatively rare cases of encephalopathy and encephalitis. OBJECTIVE: This report explains that autism is not a physical or neurological disorder. It is not caused by injury or disease of the brain. It is a developmental disorder that has no physical origins and no physical symptoms. It is extremely unlikely that vaccines are causing autism; but it is extremely likely that they are causing more neurological damage than currently appreciated, some of it resulting in psychosocial disabilities that can be confused with autism and other psychosocial disorders. This confusion between a developmental, psychosocial disorder and a physical neurological disease has played into the hands of interest groups who want to deny that vaccines have any neurological and associated neuropsychiatric effects. METHODS: A review of the scientific literature, textbooks, and related media commentary is integrated with basic clinical knowledge. RESULTS: This report shows how scientific sources have used the vaccine/autism controversy to avoid dealing with genuine neurological risks associated with vaccines and summarizes evidence that vaccines, including the MMR, can cause serious neurological disorders. Manufacturers have been allowed by the US Food and Drug Administration (FDA) to gain vaccine approval without placebo-controlled clinical trials. CONCLUSIONS: The misleading vaccine autism controversy must be set aside in favor of examining actual neurological harms associated with vaccines, including building on existing research that has been ignored. Manufacturers of vaccines must be required to conduct placebo-controlled clinical studies for existing vaccines and for government approval of new vaccines. Many probable or confirmed neurological adverse events occur within a few days or weeks after immunization and could be detected if the trials were sufficiently large. Contrary to current opinion, large, long-term placebo-controlled trials of existing and new vaccines would be relatively easy and safe to conduct.


Sign in / Sign up

Export Citation Format

Share Document