Computational Blood Flow Modeling Based on In Vivo Measurements

10.1114/1.221 ◽  
1999 ◽  
Vol 27 (5) ◽  
pp. 627-640 ◽  
Author(s):  
J. A. Moore ◽  
Brian K. Rutt ◽  
Stephen J. Karlik ◽  
Kevin Yin ◽  
C. Ross Ethier
Keyword(s):  
Blood Flow ◽  
Flow Modeling ◽  
In Vivo Measurements ◽  
Blood Flow Modeling

Abstract 16856: Mathematical Modeling of Blood Flow to Evaluate the Hemodynamic Significance of Peripheral Vascular Lesions

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Seyed Mehran Mirramezani ◽  
Paul Cimadomo ◽  
Ernie Ahsan ◽  
David Shavelle ◽  
Leonardo Clavijo ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pressure Gradient ◽  
Ankle Brachial Index ◽  
Peripheral Arteries ◽  
Flow Modeling ◽  
Peripheral Vascular ◽  
Blood Flow Modeling ◽  
Resting Pressure ◽  
Grade Iii ◽  
Significant Lesion

Introduction: Evaluating the severity of lesions in peripheral arteries is challenging. Image-based blood flow modeling from peripheral computed tomographic angiography (pCTA) may provide a non-invasive method to determine the hemodynamic significance of lesions. The objective of this study was to evaluate the diagnostic performance of a trans-lesion pressure drop computed from pCTA-based blood flow modeling in the peripheral arteries. Methods: Ten patients undergoing digital subtraction angiography (DSA) and pCTA were included. The peripheral arteries were divided into 8 segments per extremity and stenosis severity was visually graded by DSA as non-stenosed (grade 0), mild (grade I), moderate (grade II), severe (grade III), occluded (grade IV) or non-evaluable. A functionally significant lesion was defined as grade III or IV by DSA. Independent from the DSA review, a resting pressure gradient (rPG) and exercise PG (ExPG) for each segment was calculated from pCTA-based blood flow modeling (Figure), and a functionally significant lesion was defined as having an rPG > 5 mm Hg or an ExPG > 20 mm Hg. Results: Mean age was 52±16 years, 4 patients (40%) were male, 8 patients (80%) presented with critical limb ischemia, mean ankle brachial index was 0.60±0.29 and 66 arterial segments were available for both assessment methods. Twenty-two segments had functionally significant lesions by DSA. For rPG, sensitivity was 80%, specificity was 85% and accuracy was 79% with DSA as the standard; for ExPG, sensitivity was 84%, specificity was 89% and accuracy was 88%. Conclusions: Use of a resting pressure gradient > 5 mm Hg and an exercise pressure gradient > 20 mm Hg measured by peripheral computed tomography-based blood flow modeling accurately identifies functionally significant stenosis in patients with advanced peripheral vascular disease. These results support a prospective imaging trial to further validate this novel approach.

Blood Flow Modeling with Microcapsular Suspensions

1969 ◽  
Vol 8 (4) ◽  
pp. 615-620 ◽  
Author(s):  
R. M. Navari ◽  
J. L. Gainer ◽  
O. L. Updike
Keyword(s):  
Blood Flow ◽  
Flow Modeling ◽  
Blood Flow Modeling
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