Blood Flow Modeling in a Healthy Carotid Artery Bifurcation: Simulations Against in Vivo Measurements

2017 ◽  
Author(s):  
Arij Debbich ◽  
Asma Ben Abdallah
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Flow Modeling ◽  
Carotid Artery Bifurcation ◽  
In Vivo Measurements ◽  
Blood Flow Modeling

Computational Blood Flow Modeling Based on In Vivo Measurements

10.1114/1.221 ◽  
1999 ◽  
Vol 27 (5) ◽  
pp. 627-640 ◽  
Author(s):  
J. A. Moore ◽  
Brian K. Rutt ◽  
Stephen J. Karlik ◽  
Kevin Yin ◽  
C. Ross Ethier
Keyword(s):  
Blood Flow ◽  
Flow Modeling ◽  
In Vivo Measurements ◽  
Blood Flow Modeling

Abstract 16856: Mathematical Modeling of Blood Flow to Evaluate the Hemodynamic Significance of Peripheral Vascular Lesions

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Seyed Mehran Mirramezani ◽  
Paul Cimadomo ◽  
Ernie Ahsan ◽  
David Shavelle ◽  
Leonardo Clavijo ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pressure Gradient ◽  
Ankle Brachial Index ◽  
Peripheral Arteries ◽  
Flow Modeling ◽  
Peripheral Vascular ◽  
Blood Flow Modeling ◽  
Resting Pressure ◽  
Grade Iii ◽  
Significant Lesion

Introduction: Evaluating the severity of lesions in peripheral arteries is challenging. Image-based blood flow modeling from peripheral computed tomographic angiography (pCTA) may provide a non-invasive method to determine the hemodynamic significance of lesions. The objective of this study was to evaluate the diagnostic performance of a trans-lesion pressure drop computed from pCTA-based blood flow modeling in the peripheral arteries. Methods: Ten patients undergoing digital subtraction angiography (DSA) and pCTA were included. The peripheral arteries were divided into 8 segments per extremity and stenosis severity was visually graded by DSA as non-stenosed (grade 0), mild (grade I), moderate (grade II), severe (grade III), occluded (grade IV) or non-evaluable. A functionally significant lesion was defined as grade III or IV by DSA. Independent from the DSA review, a resting pressure gradient (rPG) and exercise PG (ExPG) for each segment was calculated from pCTA-based blood flow modeling (Figure), and a functionally significant lesion was defined as having an rPG > 5 mm Hg or an ExPG > 20 mm Hg. Results: Mean age was 52±16 years, 4 patients (40%) were male, 8 patients (80%) presented with critical limb ischemia, mean ankle brachial index was 0.60±0.29 and 66 arterial segments were available for both assessment methods. Twenty-two segments had functionally significant lesions by DSA. For rPG, sensitivity was 80%, specificity was 85% and accuracy was 79% with DSA as the standard; for ExPG, sensitivity was 84%, specificity was 89% and accuracy was 88%. Conclusions: Use of a resting pressure gradient > 5 mm Hg and an exercise pressure gradient > 20 mm Hg measured by peripheral computed tomography-based blood flow modeling accurately identifies functionally significant stenosis in patients with advanced peripheral vascular disease. These results support a prospective imaging trial to further validate this novel approach.

scholarly journals A Systematic Review for the Design of In Vitro Flow Studies of the Carotid Artery Bifurcation

2019 ◽  
Vol 11 (2) ◽  
pp. 111-127 ◽  
Author(s):  
A. M. Hoving ◽  
E. E. de Vries ◽  
J. Mikhal ◽  
G. J. de Borst ◽  
C. H. Slump
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Flow Visualization ◽  
Design Process ◽  
Imaging Technique ◽  
Carotid Artery Disease ◽  
Imaging Techniques ◽  
Carotid Artery Bifurcation ◽  
Flow Parameters

Abstract Purpose In vitro blood flow studies in carotid artery bifurcation models may contribute to understanding the influence of hemodynamics on carotid artery disease. However, the design of in vitro blood flow studies involves many steps and selection of imaging techniques, model materials, model design, and flow visualization parameters. Therefore, an overview of the possibilities and guidance for the design process is beneficial for researchers with less experience in flow studies. Methods A systematic search to in vitro flow studies in carotid artery bifurcation models aiming at quantification and detailed flow visualization of blood flow dynamics results in inclusion of 42 articles. Results Four categories of imaging techniques are distinguished: MRI, optical particle image velocimetry (PIV), ultrasound and miscellaneous techniques. Parameters for flow visualization are categorized into velocity, flow, shear-related, turbulent/disordered flow and other parameters. Model materials and design characteristics vary between study type. Conclusions A simplified three-step design process is proposed for better fitting and adequate match with the pertinent research question at hand and as guidance for less experienced flow study researchers. The three consecutive selection steps are: flow parameters, image modality, and model materials and designs. Model materials depend on the chosen imaging technique, whereas choice of flow parameters is independent from imaging technique and is therefore only determined by the goal of the study.

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