scholarly journals Phosphodiesterase 4 inhibition attenuates plasma volume loss and transvascular exchange in volume-expanded mice

2011 ◽  
Vol 590 (2) ◽  
pp. 309-322 ◽  
Author(s):  
Yueh-Chen Lin ◽  
Roger H. Adamson ◽  
Joyce F. Clark ◽  
Rolf K. Reed ◽  
Fitz-Roy E. Curry
Keyword(s):  
Plasma Volume ◽  
Volume Loss ◽  
Phosphodiesterase 4 ◽  
Transvascular Exchange

scholarly journals Effect of Plasma Volume Loss during Graded Exercise Testing on Blood Lactate Concentration

2007 ◽  
Vol 57 (2) ◽  
pp. 95-99 ◽  
Author(s):  
James A. Davis ◽  
Ralph Rozenek ◽  
Derek M. DeCicco ◽  
Michael T. Carizzi ◽  
Patrick H. Pham
Keyword(s):  
Blood Lactate ◽  
Exercise Testing ◽  
Plasma Volume ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Volume Loss ◽  
Graded Exercise Testing ◽  
Graded Exercise

Prostacyclin reduces plasma volume loss after skeletal muscle trauma in the rat

2012 ◽  
Vol 73 (6) ◽  
pp. 1531-1536 ◽  
Author(s):  
Peter Bansch ◽  
Cornelia Lundblad ◽  
Per-Olof Grände ◽  
Peter Bentzer
Keyword(s):  
Skeletal Muscle ◽  
Plasma Volume ◽  
Volume Loss ◽  
Muscle Trauma

Nicotinic acid reduction of plasma volume loss after thermal trauma

Science ◽  
1976 ◽  
Vol 191 (4229) ◽  
pp. 861-862 ◽  
Author(s):  
J. Hilton ◽  
C. Wells
Keyword(s):  
Nicotinic Acid ◽  
Plasma Volume ◽  
Volume Loss ◽  
Thermal Trauma ◽  
Acid Reduction

The Early Effects of Intravenous Frusemide on Central Haemodynamics, Venous Tone and Plasma Renin Activity

1975 ◽  
Vol 49 (6) ◽  
pp. 551-555 ◽  
Author(s):  
B. Hesse ◽  
I. Nielsen ◽  
H. Lund-Jacobsen
Keyword(s):  
Plasma Renin Activity ◽  
Plasma Volume ◽  
Plasma Renin ◽  
Right Heart Catheterization ◽  
Renin Activity ◽  
Heart Catheterization ◽  
Volume Loss ◽  
Volume Depletion ◽  
Venous Tone ◽  
Early Effects

1. Nine patients with clinically unimportant heart disease or benign essential hypertension were given frusemide intravenously during right-heart catheterization. 2. Pressures in both atria decreased rapidly and in parallel. The magnitude of the pressure decrease was clearly related to decrease in plasma volume loss. 3. Plasma renin activity increased significantly after 5 min (P < 0·01), but did not correlate with plasma volume loss. 4. Venous tone in the forearm was unchanged. 5. It is concluded that the pressure reduction was secondary to plasma volume depletion through diuresis and that increased plasma renin activity was mainly caused by intrarenal changes.

Pentylenetetrazol (Metrazol) shock in normal and adrenalectomized dogs

1963 ◽  
Vol 205 (2) ◽  
pp. 225-229 ◽  
Author(s):  
W. W. Swingle ◽  
A. J. Swingle
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Plasma Volume ◽  
Volume Loss ◽  
Circulatory Collapse ◽  
Vascular Tree ◽  
Volume Changes ◽  
Extracellular Compartment ◽  
The Central Nervous System ◽  
Stimulation Of

Metrazol-shocked nonadrenalectomized dogs exhibit a drastic though evanescent decline in plasma volume. A similar fall in plasma volume in the adrenalectomized dog persists and culminates in circulatory collapse unless C11 oxysteroids are administered. Loss of circulating fluid volume seems not to be due to shift of water into cells since the modest increase in hematocrit is insufficient to account for the volume change, nor can the volume decline be attributed to loss of vascular fluid into the extracellular compartment; this space decreased along with the plasma volume. The plasma volume loss of Metrazol-shocked dogs without adrenals seems due to intense, unrelieved vasoconstriction initiated by massive stimulation of the central nervous system by the drug, apparently resulting in closure of much of the vascular periphery, sequestration, and trapping of fluid and cells. Glucocorticoids somehow relieve the vasoconstriction and re-establish free blood flow at the periphery of the vascular tree. The fleeting elevation of plasma Na characteristic of Metrazol shock is independent of plasma volume changes and probably neurogenic in origin.

Effects of short duration high intensity competition on cardiac and cell damage biomarkers

2020 ◽  
pp. 1-8
Author(s):  
A. Kashef ◽  
A. Sadeghi Nikoo
Keyword(s):  
Short Duration ◽  
Plasma Volume ◽  
High Intensity ◽  
Cardiac Troponin ◽  
Cell Damage ◽  
Cardiac Biomarkers ◽  
Volume Loss ◽  
Raw Data ◽  
Creatine Kinase Mb ◽  
Significant Difference

The purpose of this study was to investigate the cardiac biomarkers like cardiac troponin T (cTnT), cardiac troponin I, and creatine kinase-MB (CK-MB) and the cell damage biomarkers including creatine phosphokinase (CPK), C-reactive protein (CRP), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in response to a short-duration high-intensity competition with correction of the post-exercise raw data with the plasma volume loss in trained athletes. Thirty-two male athletes (age, 26.9±4.7 years) competed in 8 min high-intensity competition. The competition items included: running for 400 meters; three-stage deadlifting; bar pulling up; and 30 kg kettlebell swinging. Venous blood samples were obtained before and immediately after the competition and biomarkers analysed. Plasma volume changes were estimated from haemoglobin and haematocrit readings before and after the competition. A significant increase was shown immediately after the competition compared to resting in cTnT, AST, ALT, CPK, and CRP (P<0/001). CK-MB showed no significant difference. When raw data were corrected for plasma volume loss, CPK showed a significant increase (P<0.001), and LDH and CK-MB a significant decrease (P<0.001), however cTnT, AST, ALT and CRP showed no significant difference. The plasma volume loss can affect the response of cardiac and cellular damage biomarkers to exercise. High-intensity competition for 8 min did not elevate the cardiac biomarkers, but elevated the muscle biomarkers.

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