scholarly journals In vivotwo-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice

2011 ◽  
Vol 589 (10) ◽  
pp. 2447-2457 ◽  
Author(s):  
Jun Noguchi ◽  
Akira Nagaoka ◽  
Satoshi Watanabe ◽  
Graham C. R. Ellis-Davies ◽  
Kazuo Kitamura ◽  
...  
Keyword(s):  
Structure Function ◽  
Dendritic Spines ◽  
Adult Mice

In vivo two-photon uncaging of glutamate revealing the structure–function relationships of dendritic spines in the neocortex of adult mice

2011 ◽  
Vol 71 ◽  
pp. e206
Author(s):  
Jun Noguchi ◽  
Akira Nagaoka ◽  
Satoshi Watanabe ◽  
Graham C.R. Ellis-Davies ◽  
Kazuo Kitamura ◽  
...  
Keyword(s):  
Structure Function ◽  
Dendritic Spines ◽  
Two Photon ◽  
Adult Mice

scholarly journals Lifelong Exposure to Bisphenol A Alters Cardiac Structure/Function, Protein Expression, and DNA Methylation in Adult Mice

2013 ◽  
Vol 133 (1) ◽  
pp. 174-185 ◽  
Author(s):  
Bhavini B. Patel ◽  
Mohamad Raad ◽  
Igal A. Sebag ◽  
Lorraine E. Chalifour
Keyword(s):  
Dna Methylation ◽  
Bisphenol A ◽  
Protein Expression ◽  
Structure Function ◽  
Cardiac Structure ◽  
Adult Mice

scholarly journals Reduced Dendritic Spines in the Visual Cortex Contralateral to the Optic Nerve Crush Eye in Adult Mice

2020 ◽  
Vol 61 (10) ◽  
pp. 55 ◽  
Author(s):  
Zongyi Zhan ◽  
Yali Wu ◽  
Zitian Liu ◽  
Yadan Quan ◽  
Deling Li ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Optic Nerve ◽  
Dendritic Spines ◽  
Optic Nerve Crush ◽  
Nerve Crush ◽  
Adult Mice

scholarly journals Contribution of PSD-95 protein to reward location memory

2019 ◽  
Author(s):  
Anna Cały ◽  
Małgorzata Alicja Śliwińska ◽  
Magdalena Ziółkowska ◽  
Kacper Łukasiewicz ◽  
Roberto Pagano ◽  
...  
Keyword(s):  
Dendritic Spines ◽  
Molecular Mechanisms ◽  
Stratum Radiatum ◽  
Synaptic Density ◽  
Dynamic Regulation ◽  
Location Memory ◽  
Adult Mice ◽  
Area Ca1 ◽  
Old Mice

AbstractThe molecular mechanisms involved in formation of memory are still poorly understood. We focus here on the function of post-synaptic density protein 95 (PSD-95) and its phosphorylation by CaMKII in spontaneous learning about reward location in female mice. We show that formation of reward location memory leads to downregulation of PSD-95 protein in dendritic spines of thestratum radiatum, area CA1, and selective shrinkage of dendritic spines that contain PSD-95. ShRNA-driven, long-term downregulation of PSD-95 in the area CA1 decreases precision of memory. Autophosphorylation deficient CaMKII mutant mice (CaMKII:T286A) need more time than wild-type animals to learn the location of reward. The same impairment is observed after CA1-targeted overexpression of CaMKII phosphorylation-deficient form of PSD-95 (PSD-95:S73A). In contrast to young adult mice, in aged animals reward location learning affects only spines that lack PSD-95. The frequency and size of the spines without PSD-95 are increased, while shRNA targeted to PSD-95 affects neither speed of learning nor precision of memory indicating alternative mechanisms to support successful memory formation in old mice. Altogether, our data suggest that dynamic regulation of PSD-95 expression is a mechanism that accelerates learning and improves precision of reward location memory in young mice. The function of PSD-95 in memory processes changes in aged animals.

scholarly journals Formation of Dendritic Spines with GABAergic Synapses Induced by Whisker Stimulation in Adult Mice

Neuron ◽  
2002 ◽  
Vol 34 (2) ◽  
pp. 265-273 ◽  
Author(s):  
Graham W. Knott ◽  
Charles Quairiaux ◽  
Christel Genoud ◽  
Egbert Welker
Keyword(s):  
Dendritic Spines ◽  
Adult Mice ◽  
Gabaergic Synapses ◽  
Whisker Stimulation

Binucleate Spermiogenesis in the Mouse

1972 ◽  
Vol 30 ◽  
pp. 112-113
Author(s):  
John J. Wolosewick
Keyword(s):  
Electron Microscopy ◽  
Phosphate Buffer ◽  
Seminiferous Epithelium ◽  
Mouse Testis ◽  
Germinal Epithelium ◽  
Intercellular Bridges ◽  
Adult Mice ◽  
Cervical Dislocation ◽  
Human And Mouse

Classically, the male germinal epithelium is depicted as synchronously developing uninucleate spermatids conjoined by intercellular bridges. Recently, binucleate and multinucleate spermatids from human and mouse testis have been reported. The present paper describes certain developmental events in one type of binucleate spermatid in the seminiferous epithelium of the mouse.Testes of adult mice (ABP Jax) were removed from the animals after cervical dislocation and placed into 2.5% glutaraldehyde/Millonig's phosphate buffer (pH 7.2). Testicular capsules were gently split and separated, exposing the tubules. After 15 minutes the tissue was carefully cut into cubes (approx. 1mm), fixed for an additional 45 minutes and processed for electron microscopy.

Synaptic organization of the gustatory NST

1994 ◽  
Vol 52 ◽  
pp. 150-151
Author(s):  
M. C. Whitehead
Keyword(s):  
Central Nervous System ◽  
Dendritic Spines ◽  
Fundamental Problem ◽  
Cell Types ◽  
Brain Regions ◽  
Excitatory Synapses ◽  
Solitary Tract ◽  
Synaptic Organization ◽  
Synaptic Junctions ◽  
Afferent Terminals

A fundamental problem in taste research is to determine how gustatory signals are processed and disseminated in the mammalian central nervous system. An important first step toward understanding information processing is the identification of cell types in the nucleus of the solitary tract (NST) and their synaptic relationships with oral primary afferent terminals. Facial and glossopharyngeal (LIX) terminals in the hamster were labelled with HRP, examined with EM, and characterized as containing moderate concentrations of medium-sized round vesicles, and engaging in asymmetrical synaptic junctions. Ultrastructurally the endings resemble excitatory synapses in other brain regions.Labelled facial afferent endings in the RC subdivision synapse almost exclusively with distal dendrites and dendritic spines of NST cells. Most synaptic relationships between the facial synapses and the dendrites are simple. However, 40% of facial endings engage in complex synaptic relationships within glomeruli containing unlabelled axon endings particularly ones termed "SP" endings. SP endings are densely packed with small, pleomorphic vesicles and synapse with both the facial endings and their postsynaptic dendrites by means of nearly symmetrical junctions.

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