scholarly journals Reduced Dendritic Spines in the Visual Cortex Contralateral to the Optic Nerve Crush Eye in Adult Mice

2020 ◽  
Vol 61 (10) ◽  
pp. 55 ◽  
Author(s):  
Zongyi Zhan ◽  
Yali Wu ◽  
Zitian Liu ◽  
Yadan Quan ◽  
Deling Li ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Optic Nerve ◽  
Dendritic Spines ◽  
Optic Nerve Crush ◽  
Nerve Crush ◽  
Adult Mice

scholarly journals Nerve fibre layer degeneration and retinal ganglion cell loss long term after optic nerve crush or transection in adult mice

2018 ◽  
Vol 170 ◽  
pp. 40-50 ◽  
Author(s):  
M.C. Sánchez-Migallón ◽  
F.J. Valiente-Soriano ◽  
M. Salinas-Navarro ◽  
F.M. Nadal-Nicolás ◽  
M. Jiménez-López ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Fibre ◽  
Cell Loss ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Adult Mice ◽  
Nerve Fibre Layer

scholarly journals NGF Eye Administration Recovers the TrkB and Glutamate/GABA Marker Deficit in the Adult Visual Cortex Following Optic Nerve Crush

2021 ◽  
Vol 22 (18) ◽  
pp. 10014
Author(s):  
Pamela Rosso ◽  
Elena Fico ◽  
Louise A. Mesentier-Louro ◽  
Viviana Triaca ◽  
Alessandro Lambiase ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Glutamatergic Transmission ◽  
Cell Soma ◽  
Nerve Crush ◽  
Cellular Targets ◽  
Activity Dependent ◽  
Human Nerve ◽  
The Brain

Eye-drop recombinant human nerve growth factor (ed-rhNGF) has proved to recover the retina and optic nerve damage in animal models, including the unilateral optic nerve crush (ONC), and to improve visual acuity in humans. These data, associated with evidence that ed-rhNGF stimulates the brain derived neurotrophic factor (BDNF) in retina and cortex, suggests that NGF might exert retino-fugal effects by affecting BDNF and its receptor TrkB. To address these questions, their expression and relationship with the GABAergic and glutamatergic transmission markers, GAD65 and GAD67, vesicular inhibitory amino acid transporter (VGAT), and vesicular glutamate transporters 1 and 2 (VGLUT-1 and VGLUT-2) were investigated in adult ONC rats contralateral and ipsilateral visual cortex (VCx). Ed-rhNGF recovers the ONC-induced alteration of GABAergic and glutamatergic markers in contralateral VCx, induces an upregulation of TrkB, which is positively correlated with BDNF precursor (proBDNF) decrease in both VCx sides, and strongly enhances TrkB+ cell soma and neuronal endings surrounded by GAD65 immuno-reactive afferents. These findings contribute to enlarging the knowledge on the mechanism of actions and cellular targets of exogenously administrated NGF, and suggest that ed-rhNGF might act by potentiating the activity-dependent TrkB expression in GAD+ cells in VCx following retina damage and/or ONC.

scholarly journals Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Mira Chamoun ◽  
Elena G. Sergeeva ◽  
Petra Henrich-Noack ◽  
Shaobo Jia ◽  
Lisa Grigartzik ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Optic Nerve ◽  
Evoked Potentials ◽  
Visual Function ◽  
Cortical Plasticity ◽  
Brightness Discrimination ◽  
Acetylcholinesterase Inhibitor ◽  
Optic Nerve Crush ◽  
Adult Rats ◽  
Nerve Crush

Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function restoration. To this end, we evaluated for 4 weeks the effect of the acetylcholinesterase inhibitor donepezil on brightness discrimination, visually evoked potentials, and visual cortex reactivity after a bilateral and partial optic nerve crush in adult rats. Donepezil administration enhanced brightness discrimination capacity after optic nerve crush compared to nontreated animals. The visually evoked activation of the primary visual cortex was not restored, as measured by evoked potentials, but the cortical neuronal activity measured by thallium autometallography was not significantly affected four weeks after the optic nerve crush. Altogether, the results suggest a role of the cholinergic system in postlesion cortical plasticity. This finding agrees with the view that restoration of visual function may involve mechanisms beyond the area of primary damage and opens a new perspective for improving visual rehabilitation in humans.

scholarly journals Altered Neuronal Activity Patterns in the Visual Cortex of the Adult Rat after Partial Optic Nerve Crush—A Single-Cell Resolution Metabolic Mapping Study

2011 ◽  
Vol 22 (8) ◽  
pp. 1824-1833 ◽  
Author(s):  
Tamar Macharadze ◽  
Rainer Pielot ◽  
Tim Wanger ◽  
Henning Scheich ◽  
Eckart D. Gundelfinger ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Optic Nerve ◽  
Single Cell ◽  
Neuronal Activity ◽  
Activity Patterns ◽  
Optic Nerve Crush ◽  
Mapping Study ◽  
Nerve Crush ◽  
Metabolic Mapping ◽  
Adult Rat

Different functional susceptibilities of mouse retinal ganglion cell subtypes to optic nerve crush injury

2017 ◽  
Vol 162 ◽  
pp. 97-103 ◽  
Author(s):  
Zhen Puyang ◽  
Hai-Qing Gong ◽  
Shi-Gang He ◽  
John B. Troy ◽  
Xiaorong Liu ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Crush Injury ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Nerve Crush Injury
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