scholarly journals In pursuit of the high-resolution structure of nicotinic acetylcholine receptors

2010 ◽  
Vol 588 (4) ◽  
pp. 557-564 ◽  
Author(s):  
Lin Chen
Keyword(s):  
High Resolution ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine ◽  
High Resolution Structure ◽  
Resolution Structure

scholarly journals Pursuing High-Resolution Structures of Nicotinic Acetylcholine Receptors: Lessons Learned from Five Decades

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5753
Author(s):  
Manuel Delgado-Vélez ◽  
Orestes Quesada ◽  
Juan C. Villalobos-Santos ◽  
Rafael Maldonado-Hernández ◽  
Guillermo Asmar-Rovira ◽  
...  
Keyword(s):  
High Resolution ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Structural Features ◽  
Lessons Learned ◽  
Nicotinic Acetylcholine ◽  
Disease States ◽  
Pharmacological Targets ◽  
Therapeutic Value ◽  
Effective Drugs

Since their discovery, nicotinic acetylcholine receptors (nAChRs) have been extensively studied to understand their function, as well as the consequence of alterations leading to disease states. Importantly, these receptors represent pharmacological targets to treat a number of neurological and neurodegenerative disorders. Nevertheless, their therapeutic value has been limited by the absence of high-resolution structures that allow for the design of more specific and effective drugs. This article offers a comprehensive review of five decades of research pursuing high-resolution structures of nAChRs. We provide a historical perspective, from initial structural studies to the most recent X-ray and cryogenic electron microscopy (Cryo-EM) nAChR structures. We also discuss the most relevant structural features that emerged from these studies, as well as perspectives in the field.

Nicotinic acetylcholine receptors in the patients with Parkinson's disease: 5IA-SPECT

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S586-S586 ◽  
Author(s):  
Kazuo Hashikawa ◽  
Hidefumi Yoshida ◽  
Nobukatsu Sawamoto ◽  
Shigetoshi Takaya ◽  
Chihiro Namiki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine
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