scholarly journals AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep

2008 ◽  
Vol 586 (10) ◽  
pp. 2651-2664 ◽  
Author(s):  
Mei J. Zhu ◽  
Bin Han ◽  
Junfeng Tong ◽  
Changwei Ma ◽  
Jessica M. Kimzey ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Muscle Development ◽  
Signalling Pathways ◽  
Skeletal Muscle Development ◽  
Amp Activated Protein Kinase ◽  
Protein Kinase Signalling

scholarly journals AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle

2020 ◽  
Vol 134 (17) ◽  
pp. 2381-2398
Author(s):  
Miao Chen ◽  
Caoyu Ji ◽  
Qingchen Yang ◽  
Shuya Gao ◽  
Yue Peng ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Development ◽  
The Body ◽  
Glucose Disposal ◽  
Ampk Activation ◽  
Skeletal Muscle Development ◽  
Ampk Signaling ◽  
Expression Of Genes ◽  
Total Glucose ◽  
Amp Activated Protein Kinase

Abstract Skeletal muscle is responsible for the majority of glucose disposal in the body. Insulin resistance in the skeletal muscle accounts for 85–90% of the impairment of total glucose disposal in patients with type 2 diabetes (T2D). However, the mechanism remains controversial. The present study aims to investigate whether AKT2 deficiency causes deficits in skeletal muscle development and metabolism, we analyzed the expression of molecules related to skeletal muscle development, glucose uptake and metabolism in mice of 3- and 8-months old. We found that AMP-activated protein kinase (AMPK) phosphorylation and myocyte enhancer factor 2 (MEF2) A (MEF2A) expression were down-regulated in AKT2 knockout (KO) mice, which can be inverted by AMPK activation. We also observed reduced mitochondrial DNA (mtDNA) abundance and reduced expression of genes involved in mitochondrial biogenesis in the skeletal muscle of AKT2 KO mice, which was prevented by AMPK activation. Moreover, AKT2 KO mice exhibited impaired AMPK signaling in response to insulin stimulation compared with WT mice. Our study establishes a new and important function of AKT2 in regulating skeletal muscle development and glucose metabolism via AMPK-dependent signaling.

scholarly journals Many routes to the same destination: lessons from skeletal muscle development

Reproduction ◽  
2011 ◽  
Vol 141 (3) ◽  
pp. 301-312 ◽  
Author(s):  
Gi Fay Mok ◽  
Dylan Sweetman
Keyword(s):  
Skeletal Muscle ◽  
Muscle Development ◽  
Cell Types ◽  
Signalling Pathways ◽  
Specific Cell ◽  
Myogenic Regulatory Factors ◽  
Skeletal Muscle Development ◽  
Molecular Events ◽  
Development And Differentiation ◽  
Vertebrate Skeletal Muscle

The development and differentiation of vertebrate skeletal muscle provide an important paradigm to understand the inductive signals and molecular events controlling differentiation of specific cell types. Recent findings show that a core transcriptional network, initiated by the myogenic regulatory factors (MRFs; MYF5, MYOD, myogenin and MRF4), is activated by separate populations of cells in embryos in response to various signalling pathways. This review will highlight how cells from multiple distinct starting points can converge on a common set of regulators to generate skeletal muscle.

Chronic activation of AMP-activated protein kinase increases monocarboxylate transporter 2 and 4 expression in skeletal muscle

2017 ◽  
Vol 95 (8) ◽  
pp. 3552
Author(s):  
E. M. England ◽  
H. Shi ◽  
S. K. Matarneh ◽  
E. M. Oliver ◽  
E. T. Helm ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Monocarboxylate Transporter ◽  
Chronic Activation ◽  
Amp Activated Protein Kinase
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