Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells

2021 ◽  
Author(s):  
Xin Zhan ◽  
Yiran Xie ◽  
Liping Sun ◽  
Qi Si ◽  
Hongkai Shang
Keyword(s):  
Reactive Oxygen Species ◽  
Protein Kinase ◽  
Glucocorticoid Receptors ◽  
Mammalian Target Of Rapamycin ◽  
Reactive Oxygen ◽  
Signalling Pathways ◽  
Oxygen Species ◽  
Phosphatidylinositol 3 Kinase ◽  
Amp Activated Protein Kinase ◽  
Protein Kinase Signalling

scholarly journals Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200508
Author(s):  
Zi-Han Tian ◽  
Jueng-Tsueng Weng ◽  
Li-Jane Shih ◽  
An-Ci Siao ◽  
Tsai-Yun Chan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Protein Kinase ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Amp Activated Protein Kinase

scholarly journals Reactive Oxygen Species-Induced Stimulation of 5'AMP-Activated Protein Kinase Mediates Sevoflurane-Induced Cardioprotection

Circulation ◽  
2009 ◽  
Vol 120 (11_suppl_1) ◽  
pp. S10-S15 ◽  
Author(s):  
R. R. Lamberts ◽  
G. Onderwater ◽  
N. Hamdani ◽  
M. J. A. Vreden ◽  
J. Steenhuisen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Protein Kinase ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Amp Activated Protein Kinase ◽  
Stimulation Of

Exercise-induced immunosuppression: roles of reactive oxygen species and 5′-AMP-activated protein kinase dephosphorylation within immune cells

2010 ◽  
Vol 108 (5) ◽  
pp. 1284-1292 ◽  
Author(s):  
Hannah Moir ◽  
Michael G. Hughes ◽  
Stephen Potter ◽  
Craig Sims ◽  
Lee R. Butcher ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Protein Kinase ◽  
Immune Cells ◽  
Mononuclear Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Ampk Phosphorylation ◽  
Intracellular Ros ◽  
Exercise Induced ◽  
Amp Activated Protein Kinase

We previously proposed 5′-AMP-activated protein kinase (AMPK) dephosphorylation within immune cells as an intracellular mechanism linking exercise and immunosuppression. In this study, AMPK phosphorylation underwent transient (<1 h) decreases (53.8 ± 7.2% basal) immediately after exercise (45 min of cycling at 70% V̇o2max) in a cohort of 16 adult male participants. Similar effects were seen with running. However, because exercise-induced inactivation of AMPK was previously shown to occur in an AMP-independent manner, the means by which AMPK is inactivated in this context is not yet clear. To investigate the hypothesis that exercise-induced inactivation of AMPK is mediated via signaling mechanisms distinct from changes in cellular AMP-to-ATP ratios, reactive oxygen species (ROS) and intracellular Ca2+ signaling were investigated in mononuclear cells before and after exercise and in cultured monocytic MM6 cells. In in vitro studies, treatment with an antioxidant (ascorbic acid, 4 h, 50 μM) decreased MM6 cell intracellular ROS levels (88.0 ± 5.2% basal) and induced dephosphorylation of AMPK (44.7 ± 17.6% basal). By analogy, the fact that exercise decreased mononuclear cell ROS content (32.8 ± 16.6% basal), possibly due to downregulation (43.4 ± 8.0% basal) of mRNA for NOX2, the catalytic subunit of the cytoplasmic ROS-generating enzyme NADPH oxidase, may provide an explanation for the AMPK-dephosphorylating effect of exercise. In contrast, exercise-induced Ca2+ signaling events did not seem to be coupled to changes in AMPK activity. Thus we propose that the exercise-induced decreases in both intracellular ROS and AMPK phosphorylation seen in this study constitute evidence supporting a role for ROS in controlling AMPK, and hence immune function, in the context of exercise-induced immunosuppression.

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