scholarly journals Brain-derived neurotrophic factor attenuates mouse cerebellar granule cell GABAA receptor-mediated responses via postsynaptic mechanisms

2003 ◽  
Vol 548 (3) ◽  
pp. 711-721 ◽  
Author(s):  
Q. Cheng ◽  
H. H Yeh
Keyword(s):  
Gabaa Receptor ◽  
Granule Cell ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cerebellar Granule Cell ◽  
Cerebellar Granule

Developmental expression of the α6 GABAA receptor subunit mRNA occurs only after cerebellar granule cell migration

1993 ◽  
Vol 75 (1) ◽  
pp. 91-103 ◽  
Author(s):  
Tian Zheng ◽  
Maria-Rita Santi ◽  
Patrizia Bovolin ◽  
Lionel N.J-L. Marlier ◽  
Dennis R. Grayson
Keyword(s):  
Cell Migration ◽  
Gabaa Receptor ◽  
Granule Cell ◽  
Cerebellar Granule Cell ◽  
Developmental Expression ◽  
Receptor Subunit ◽  
Cerebellar Granule ◽  
Subunit Mrna

scholarly journals A Reinforcing Circuit Action of Extrasynaptic GABAA Receptor Modulators on Cerebellar Granule Cell Inhibition

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72976 ◽  
Author(s):  
Vijayalakshmi Santhakumar ◽  
Pratap Meera ◽  
Movses H. Karakossian ◽  
Thomas S. Otis
Keyword(s):  
Gabaa Receptor ◽  
Granule Cell ◽  
Cerebellar Granule Cell ◽  
Cerebellar Granule ◽  
Cell Inhibition ◽  
Receptor Modulators

scholarly journals Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins

2020 ◽  
Author(s):  
Takeshi Uemura ◽  
Emi Suzuki ◽  
Shiori Kawase ◽  
Taiga Kurihara ◽  
Misato Yasumura ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cell Survival ◽  
Granule Cell ◽  
Neurotrophic Factors ◽  
Neurotrophic Factor ◽  
Cell Adhesion Molecules ◽  
Cerebellar Granule Cell ◽  
Cerebellar Granule ◽  
Protein Clusters ◽  
Presynaptic Protein

ABSTRACTNeurexins (NRXNs) are among the key presynaptic cell adhesion molecules that regulate synapse function and formation via trans-synaptic interaction with postsynaptic ligands. Here, we generated cerebellar granule cell (CGC)-specific Nrxn triple-knockout (TKO) mice to allow the deletion of all NRXNs. Unexpectedly, most CGCs died in these mice. The requirement of NRNXs for cell survival was reproduced in cultured CGCs. We showed that the axons of cultured Nrxn TKO CGCs that were not in contact with the postsynaptic structure had defects in the formation of presynaptic protein cluster and action potential-induced Ca2+ influx. Additionally, these cells were impaired in the secretion from axons of depolarization-induced fluorescence-tagged brain-derived neurotrophic factor (BDNF), and the cell-survival defect was rescued by the application of BDNF. Our results suggest that CGC survival is maintained by autocrine neurotrophic factors, and that NRXNs organize the presynaptic protein clusters and the autocrine neurotrophic factor secretory machinery independent of contact with postsynaptic ligands.

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