scholarly journals Kinetic properties of the glycine receptor main- and sub-conductance states of mouse spinal cord neurones in culture.

1991 ◽  
Vol 435 (1) ◽  
pp. 303-331 ◽  
Author(s):  
R E Twyman ◽  
R L Macdonald
Keyword(s):  
Spinal Cord ◽  
Glycine Receptor ◽  
Kinetic Properties ◽  
Mouse Spinal Cord ◽  
Conductance States

scholarly journals Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord

2022 ◽  
Vol 23 (2) ◽  
pp. 834
Author(s):  
Chigusa Shimizu-Okabe ◽  
Shiori Kobayashi ◽  
Jeongtae Kim ◽  
Yoshinori Kosaka ◽  
Masanobu Sunagawa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Radial Glia ◽  
Ventricular Zone ◽  
Glycine Receptor ◽  
Ventral Horn ◽  
Gabaergic Neurons ◽  
Inhibitory Neurons ◽  
Gamma Aminobutyric Acid ◽  
Mouse Spinal Cord ◽  
Mature Mouse

Gamma-aminobutyric acid (GABA) and glycine act as inhibitory neurotransmitters. Three types of inhibitory neurons and terminals, GABAergic, GABA/glycine coreleasing, and glycinergic, are orchestrated in the spinal cord neural circuits and play critical roles in regulating pain, locomotive movement, and respiratory rhythms. In this study, we first describe GABAergic and glycinergic transmission and inhibitory networks, consisting of three types of terminals in the mature mouse spinal cord. Second, we describe the developmental formation of GABAergic and glycinergic networks, with a specific focus on the differentiation of neurons, formation of synapses, maturation of removal systems, and changes in their action. GABAergic and glycinergic neurons are derived from the same domains of the ventricular zone. Initially, GABAergic neurons are differentiated, and their axons form synapses. Some of these neurons remain GABAergic in lamina I and II. Many GABAergic neurons convert to a coreleasing state. The coreleasing neurons and terminals remain in the dorsal horn, whereas many ultimately become glycinergic in the ventral horn. During the development of terminals and the transformation from radial glia to astrocytes, GABA and glycine receptor subunit compositions markedly change, removal systems mature, and GABAergic and glycinergic action shifts from excitatory to inhibitory.

scholarly journals Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord

2021 ◽  
Author(s):  
Chigusa Shimizu-Okabe ◽  
Shiori Kobayashi ◽  
Jeongtae Kim ◽  
Yoshinori Kosaka ◽  
Masanobu Sunagawa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Radial Glia ◽  
Ventricular Zone ◽  
Glycine Receptor ◽  
Ventral Horn ◽  
Gabaergic Neurons ◽  
Inhibitory Neurons ◽  
Gamma Aminobutyric Acid ◽  
Mouse Spinal Cord ◽  
Mature Mouse

Gamma-aminobutyric acid (GABA) and glycine act as inhibitory neurotransmitters. Three types of inhibitory neurons and terminals, GABAergic, GABA/glycine co-releasing, and glycinergic, are orchestrated in the spinal cord neural circuits and play key roles in the regulation of pain, locomotive movement, and respiratory rhythms. Herein, we first describe GABAergic and glycinergic transmission and inhibitory networks, which consist of three types of terminals, in the mature mouse spinal cord. Second, we describe the developmental formation of GABAergic and glycinergic networks, with specific focus on the differentiation of neurons, formation of synapses, maturation of removal systems, and changes in their action. GABAergic and glycinergic neurons are derived from the same domains of the ventricular zone. Initially, GABAergic neurons are differentiated and their axons form synapses. Some of these neurons remain GABAergic in lamina I and II. Many of GABAergic neurons convert to co-releasing state. The co-releasing neurons and terminals remain in the dorsal horn, whereas many of co-releasing ones ultimately become glycinergic in the ventral horn. During the development of terminals and the transformation from radial glia to astrocytes, GABA and glycine receptor subunit compositions markedly change, removal systems mature, and GABAergic and glycinergic action shifts from excitatory to inhibitory.

Primary cultures of mouse spinal cord express the neonatal isoform of the inhibitory glycine receptor

Neuron ◽  
1989 ◽  
Vol 3 (3) ◽  
pp. 339-348 ◽  
Author(s):  
Werner Hoch ◽  
Heinrich Betz ◽  
Cord-Michael Becker
Keyword(s):  
Spinal Cord ◽  
Glycine Receptor ◽  
Primary Cultures ◽  
Mouse Spinal Cord

Antagonist-induced opiate receptor upregulation in cultures of fetal mouse spinal cord-ganglion explants

1986 ◽  
Vol 390 (2) ◽  
pp. 287-291 ◽  
Author(s):  
A TEMPEL ◽  
S CRAIN ◽  
E PETERSON ◽  
E SIMON ◽  
R SUZANNEZUKIN
Keyword(s):  
Spinal Cord ◽  
Opiate Receptor ◽  
Fetal Mouse ◽  
Mouse Spinal Cord ◽  
Receptor Upregulation

scholarly journals Cytokine inflammatory threat, but not LPS one, shortens GABAergic synaptic currents in the mouse spinal cord organotypic cultures

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Vincenzo Giacco ◽  
Giulia Panattoni ◽  
Manuela Medelin ◽  
Elena Bonechi ◽  
Alessandra Aldinucci ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Organotypic Cultures ◽  
Synaptic Currents ◽  
Mouse Spinal Cord
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