scholarly journals Effects of age on calcium transport activity of sarcoplasmic reticulum in fast- and slow-twitch rat muscle fibres.

1989 ◽  
Vol 419 (1) ◽  
pp. 253-264 ◽  
Author(s):  
L Larsson ◽  
G Salviati
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Calcium Transport ◽  
Muscle Fibres ◽  
Transport Activity ◽  
Rat Muscle ◽  
Slow Twitch

Early effects of denervation on sarcoplasmic reticulum properties of slow-twitch rat muscle fibres

1997 ◽  
Vol 434 (4) ◽  
pp. 398-405 ◽  
Author(s):  
M. Midrio ◽  
Daniela Danieli-Betto ◽  
Aram Megighian ◽  
Romeo Betto
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Muscle Fibres ◽  
Rat Muscle ◽  
Slow Twitch ◽  
Early Effects

Isolation and Characteristics of Scallop Sarcoplasmic Reticulum with Calcium Transport Activity

1992 ◽  
Vol 112 (6) ◽  
pp. 822-827 ◽  
Author(s):  
Michikazu Abe ◽  
Yumiko Shirakata ◽  
Dai Sato ◽  
Kazuhiko Koniahi ◽  
Tsuyoshi Watanabe ◽  
...  
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Calcium Transport ◽  
Transport Activity

Total adenine nucleotide stores and sarcoplasmic reticular Ca transport in ischemic rat heart

1984 ◽  
Vol 247 (3) ◽  
pp. H380-H386 ◽  
Author(s):  
H. Meno ◽  
H. Kanaide ◽  
M. Okada ◽  
M. Nakamura
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Calcium Transport ◽  
Rat Heart ◽  
Perfusion Pressure ◽  
Adenine Nucleotide ◽  
Aerobic Condition ◽  
Isolated Rat Heart ◽  
Ischemia And Reperfusion ◽  
Transport Activity ◽  
Nucleotide Level

We studied the relation between the contractility and metabolic changes in reperfusion after ischemia, and the effect of diltiazem on these changes, in an isolated rat heart perfused using the Langendorff method. After aerobic perfusion at 80 cmH2O, the perfusion pressure was reduced to 10 cmH2O to induce global ischemia. Substrate was removed from the perfusate during ischemia. After 30 or 60 min of ischemia, the heart was reperfused in an aerobic condition. During ischemia, the total adenine nucleotide level (TAN: sum of ATP, ADP, and AMP) was progressively reduced and the ATP-to-ADP ratio was one-third of the value obtained in an aerobic condition. With 30 min of subsequent reperfusion, ATP increased, and the shorter the duration of ischemia, the closer ATP/ADP approached the value of an aerobic condition, whereas TAN was equivalent to the value shown immediately before reperfusion. Thus the degree of ATP recovery by reperfusion mainly depends on the amount of TAN immediately before reperfusion and the mitochondrial function of oxidative phosphorylation that determines ATP/ADP. The calcium transport activity of the sarcoplasmic reticulum of myocardial cells was affected by ischemia and showed no amelioration or further deterioration by subsequent reperfusion. When diltiazem (10(-5)M) was added to the perfusate continuously from 5 min before ischemia, during ischemia, and until 10 min of reperfusion, the amount of TAN in ischemia and reperfusion and the calcium transport activity during reperfusion were maintained at relatively high levels. The degree of contractility recovery by reperfusion showed direct correlations with both the tissue ATP amount and the level of calcium transport activity in the sarcoplasmic reticulum.

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