scholarly journals Heterogeneous distribution of fast and slow potassium channels in myelinated rat nerve fibres.

1989 ◽  
Vol 416 (1) ◽  
pp. 93-110 ◽  
Author(s):  
J Röper ◽  
J R Schwarz
Keyword(s):  
Potassium Channels ◽  
Nerve Fibres ◽  
Heterogeneous Distribution ◽  
Slow Potassium ◽  
Rat Nerve

The cole-moore effect in nodal membrane of the frogRana ridibunda: Evidence for fast and slow potassium channels

1980 ◽  
Vol 57 (3) ◽  
pp. 179-193 ◽  
Author(s):  
V. I. Ilyin ◽  
Irene E. Katina ◽  
A. V. Lonskii ◽  
V. S. Makovsky ◽  
E. V. Polishchuk
Keyword(s):  
Potassium Channels ◽  
Nodal Membrane ◽  
Slow Potassium

Sodium and potassium channels in regenerating and developing mammalian myelinated nerves

1982 ◽  
Vol 215 (1200) ◽  
pp. 273-287 ◽  
Keyword(s):  
Potassium Channels ◽  
Action Potential ◽  
Sodium Channels ◽  
Unit Length ◽  
Nerve Fibres ◽  
Myelinated Nerve ◽  
Complementary Distribution ◽  
Myelinated Nerves ◽  
Sodium And Potassium ◽  
Regenerating Nerve

A study has been made of how the normal complementary distribution of sodium and potassium channels in mammalian myelinated nerve fibres (all the sodium channels being in the node with all the potassium channels in the internode) is altered in regenerating and in developing rabbit sciatic nerves. In regenerating nerve fibres, where a marked increase in the number of nodes per unit length occurs, there is a corresponding increase in the sodium channel content (determined from the maximum saturable binding of labelled saxitoxin), consistent with the idea that the number of sodium channels per node remains roughly constant. The use of 4-aminopyridine, which by blocking potassium channels prolongs the action potential, has shown that both in regenerating nerve fibres and in developing nerve fibres potassium currents contribute to the mammalian action potential. In both cases, with the passage of time, the sensitivity to 4-aminopyridine progressively decreases.

On the physiological role of internodal potassium channels and the security of conduction in myelinated nerve fibres

1984 ◽  
Vol 220 (1221) ◽  
pp. 415-422 ◽  
Keyword(s):  
Electrical Properties ◽  
Potassium Channels ◽  
Theoretical Analysis ◽  
Physiological Role ◽  
Resting Potential ◽  
Nerve Fibres ◽  
Myelinated Nerve ◽  
Voltage Dependent ◽  
Passive Electrical Properties

A theoretical analysis of the passive electrical properties of normal myelinated nerve suggests that the function of the voltage-dependent potassium channels in the internodal axolemma under the myelin sheath is to permit the generation of an internodal resting potential. Calculation shows that if this internodal potential were not present, the nodal potential would be reduced (by electrotonic short-circuiting) thus impairing the security of conduction. This impairment is particularly pronounced with smaller diameter fibres.

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