scholarly journals Evidence for the presence of potassium channels in the paranodal region of acutely demyelinated mammalian single nerve fibres.

1981 ◽  
Vol 313 (1) ◽  
pp. 415-437 ◽  
Author(s):  
S Y Chiu ◽  
J M Ritchie
Keyword(s):  
Potassium Channels ◽  
Nerve Fibres ◽  
Single Nerve

scholarly journals XIV.—On the Relation of Nerves to Odontoblasts, and on the Growth of Dentine

1892 ◽  
Vol 36 (2) ◽  
pp. 321-333 ◽  
Author(s):  
W. G. Aitchison Robertson
Keyword(s):  
Nervous System ◽  
Nerve Trunk ◽  
The Body ◽  
Osmic Acid ◽  
Nerve Fibres ◽  
Incisor Tooth ◽  
Highly Sensitive ◽  
Single Nerve ◽  
Lateral Branches ◽  
External Stimuli

Clinical and pathological observation both show that the dentine of the tooth is very closely connected with the nervous system, and is in consequence highly sensitive. Upon what structures does the sensibility of the dentine depend? In what manner is the dentine connected with the nerves of the pulp so as to become so sensitive to external stimuli?Perhaps there is no other structure in the body which is so largely supplied with nerves as the pulp of the tooth; even in the smallest fragment we find many nerve fibres. If we take the pulp from the incisor tooth of an ox and examine it after having allowed it to lie in a solution of osmic acid for a few minutes, we can see clearly through the darkened semi-transparent tissue a large blackened nerve trunk passing up the centre of the pulp, giving off on its way innumerable lateral branches, and dividing in a brush-like manner near the upper part of the pulp. All the fine branches are directed towards the periphery of the pulp. In longitudinal sections of the pulp we can see the same in greater detail; many large bundles of medullated and non-medullated nerve fibres running longitudinally near the centre and giving off lateral branches, which are found in great numbers near the periphery and divide into single nerve fibres just under the odontoblastic layer, being specially numerous at the apex of the pulp.

scholarly journals Resting and action potentials in single nerve fibres

1945 ◽  
Vol 104 (2) ◽  
pp. 176-195 ◽  
Author(s):  
A. L. Hodgkin ◽  
A. F. Huxley
Keyword(s):  
Action Potentials ◽  
Nerve Fibres ◽  
Single Nerve

Sodium and potassium channels in regenerating and developing mammalian myelinated nerves

1982 ◽  
Vol 215 (1200) ◽  
pp. 273-287 ◽  
Keyword(s):  
Potassium Channels ◽  
Action Potential ◽  
Sodium Channels ◽  
Unit Length ◽  
Nerve Fibres ◽  
Myelinated Nerve ◽  
Complementary Distribution ◽  
Myelinated Nerves ◽  
Sodium And Potassium ◽  
Regenerating Nerve

A study has been made of how the normal complementary distribution of sodium and potassium channels in mammalian myelinated nerve fibres (all the sodium channels being in the node with all the potassium channels in the internode) is altered in regenerating and in developing rabbit sciatic nerves. In regenerating nerve fibres, where a marked increase in the number of nodes per unit length occurs, there is a corresponding increase in the sodium channel content (determined from the maximum saturable binding of labelled saxitoxin), consistent with the idea that the number of sodium channels per node remains roughly constant. The use of 4-aminopyridine, which by blocking potassium channels prolongs the action potential, has shown that both in regenerating nerve fibres and in developing nerve fibres potassium currents contribute to the mammalian action potential. In both cases, with the passage of time, the sensitivity to 4-aminopyridine progressively decreases.

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