scholarly journals Gamma-aminobutyric acid uptake and the termination of inhibitory synaptic potentials in the rat hippocampal slice.

1985 ◽  
Vol 366 (1) ◽  
pp. 387-409 ◽  
Author(s):  
R Dingledine ◽  
S J Korn
Keyword(s):  
Hippocampal Slice ◽  
Aminobutyric Acid ◽  
Acid Uptake ◽  
Gamma Aminobutyric Acid ◽  
Synaptic Potentials

scholarly journals Concurrent acetylcholinesterase staining and gamma-aminobutyric acid uptake of cortical neurons in culture.

1981 ◽  
Vol 29 (2) ◽  
pp. 306-308 ◽  
Author(s):  
M M Mesulam ◽  
M Dichter
Keyword(s):  
Tissue Culture ◽  
Cortical Neurons ◽  
Gabaergic Neurons ◽  
Aminobutyric Acid ◽  
Gaba Uptake ◽  
Acid Uptake ◽  
Gamma Aminobutyric Acid ◽  
Acetylcholinesterase Staining ◽  
Culture Positive

Gamma-aminobutyric acid (GABA) uptake and acetylcholinesterase (AChE) content were demonstrated concurrently in cortical neurons grown in tissue culture. Positive reactions either for GABA uptake or for AChE content were encountered in pyramidal and stellate, as well as spindle-shaped neurons. Neither reaction was confined to a specific morphological subtype. Nearly half the neurons were negative for either reaction. Most of the remaining neurons were positive only for GABA or only for AChE. However, a subpopulation of neurons showed not only a high AChE content, but also an avid GABA uptake. Thus, four types of neurons could be identified on the basis of these two reactions. The high AChE content in some of the cortical neurons that also showed GABA uptake indicates that there are at least two distinct types of GABAergic neurons.

Gamma aminobutyric acid uptake, release, and effect on36Cl?-influx in bovine pineal gland

1989 ◽  
Vol 77 (2-3) ◽  
pp. 141-152 ◽  
Author(s):  
Ruth E. Rosenstein ◽  
Claudia Sanjurjo ◽  
D. P. Cardinali
Keyword(s):  
Pineal Gland ◽  
Aminobutyric Acid ◽  
Acid Uptake ◽  
Gamma Aminobutyric Acid ◽  
Bovine Pineal Gland

Extracellular alkaline transients mediated by glutamate receptors in the rat hippocampal slice are not due to a proton conductance

1994 ◽  
Vol 72 (4) ◽  
pp. 2031-2033 ◽  
Author(s):  
P. Paalasmaa ◽  
T. Taira ◽  
J. Voipio ◽  
K. Kaila
Keyword(s):  
Glutamate Receptors ◽  
Ampa Receptors ◽  
Hippocampal Slice ◽  
Aminobutyric Acid ◽  
Cation Channels ◽  
Ionic Mechanism ◽  
Synaptic Activation ◽  
Gamma Aminobutyric Acid ◽  
Proton Conductance ◽  
Ampa Receptor Channels

1. The ionic mechanism of extracellular alkaline transients mediated by alpha-amino-3-hydroxy-5-methylisoxazolate-4-propionic acid (AMPA) receptor channels was studied in the rat hippocampal slice (area CA1) by means of H(+)-, Ca(2+)- and Na(+)-selective microelectrodes. 2. Alkaline transients mediated by selective synaptic activation of AMPA receptors were coupled to a transient fall in extracellular Ca2+ ([Ca2+]o). 3. Removal of [Ca2+]o blocked the alkaline transient evoked by microinjection of AMPA, but had little effect on the simultaneous tetrodotoxin-resistant fall in extracellular Na+ ([Na+]o). 4. Alkaline transients evoked by microinjection of gamma-aminobutyric acid (GABA) were not affected by removal of [Ca2+]o. GABA had no effect on [Na+]o. 5. The present results indicate that activity-induced glutamatergic alkaline transients in the hippocampal slice are due to an influx of Ca2+, and not to a conductive movement of H+ ions across glutamate-gated cation channels.

Synthesis of alkyl-substituted arecoline derivatives as .gamma.-aminobutyric acid uptake inhibitors

1986 ◽  
Vol 29 (1) ◽  
pp. 125-132 ◽  
Author(s):  
Christian Mueller-Uri ◽  
Ernst A. Singer ◽  
Wilhelm Fleischhacker
Keyword(s):  
Aminobutyric Acid ◽  
Acid Uptake ◽  
Gamma Aminobutyric Acid ◽  
Uptake Inhibitors

scholarly journals Inhibition of high-affinity gamma-aminobutyric acid uptake in primary astrocyte cultures by phorbol esters and phospholipase C

1991 ◽  
Vol 275 (2) ◽  
pp. 435-439 ◽  
Author(s):  
J Gomeza ◽  
M Casado ◽  
C Gimenez ◽  
C Aragon
Keyword(s):  
Phospholipase C ◽  
Glial Cells ◽  
Kinase Inhibitor ◽  
Primary Cultures ◽  
Aminobutyric Acid ◽  
Gaba Uptake ◽  
Acid Uptake ◽  
Gamma Aminobutyric Acid ◽  
Gaba Transport ◽  
High Affinity

The effects of phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), on high-affinity Na(+)-dependent gamma-aminobutyric acid (GABA) uptake were investigated in primary cultures of neurons and glial cells from rat brain cortex. Incubation of glial cells with PMA led to concentration- and time-dependent decreases in the GABA transport in glial cells. This effect could be completely suppressed by addition of the PKC inhibitor H7. The PMA effects could be mimicked by oleoylacetylglycerol, the diacylglycerol kinase inhibitor R59022 and exogenous phospholipase C. Treatment with PMA did not affect GABA transport in neuronal cells.

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