Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on .gamma.-aminobutyric acid uptake and receptor binding in vitro

1981 ◽  
Vol 24 (7) ◽  
pp. 788-794 ◽  
Author(s):  
Donald T. Witiak ◽  
Kuniyuki Tomita ◽  
Raymond J. Patch ◽  
S. J. Enna
Keyword(s):  
Carboxylic Acids ◽  
Receptor Binding ◽  
Aminobutyric Acid ◽  
Acid Uptake ◽  
Gamma Aminobutyric Acid

scholarly journals Inositol incorporation into phosphoinositides in retinal horizontal cells of Xenopus laevis: enhancement by acetylcholine, inhibition by glycine.

1984 ◽  
Vol 99 (2) ◽  
pp. 686-691 ◽  
Author(s):  
R E Anderson ◽  
J G Hollyfield
Keyword(s):  
Xenopus Laevis ◽  
Culture Medium ◽  
Photoreceptor Cells ◽  
Horizontal Cells ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Light Effect ◽  
Synaptic Inputs ◽  
Absorption Of Light

The absorption of light by photoreceptor cells leads to an increased incorporation of [2-3H]inositol into phosphoinositides of horizontal cells in the retina of Xenopus laevis in vitro. We have identified several retinal neurotransmitters that are involved in regulating this response. Incubation with glycine, the neurotransmitter of an interplexiform cell that has direct synaptic input onto horizontal cells, abolishes the light effect. This inhibition is reversed by preincubation with strychnine. Acetylcholine added to the culture medium enhances the incorporation of [2-3H]inositol into phosphoinositides in horizontal cells when retinas are incubated in the dark. This effect is inhibited by preincubation with atropine. However, atropine alone does not inhibit the light-enhanced incorporation of [2-3H]inositol into phosphoinositides in the retina. gamma-Aminobutyric acid, the neurotransmitter of retinal horizontal cells in X. laevis, as well as dopamine and norepinephrine, have no effect on the incorporation of [2-3H]inositol into phosphoinositides. These studies demonstrate that the light-enhanced incorporation of [2-3H]inositol into phosphoinositides of retinal horizontal cells is regulated by specific neurotransmitters, and that there are probably several synaptic inputs into horizontal cells which control this process.

scholarly journals Concurrent acetylcholinesterase staining and gamma-aminobutyric acid uptake of cortical neurons in culture.

1981 ◽  
Vol 29 (2) ◽  
pp. 306-308 ◽  
Author(s):  
M M Mesulam ◽  
M Dichter
Keyword(s):  
Tissue Culture ◽  
Cortical Neurons ◽  
Gabaergic Neurons ◽  
Aminobutyric Acid ◽  
Gaba Uptake ◽  
Acid Uptake ◽  
Gamma Aminobutyric Acid ◽  
Acetylcholinesterase Staining ◽  
Culture Positive

Gamma-aminobutyric acid (GABA) uptake and acetylcholinesterase (AChE) content were demonstrated concurrently in cortical neurons grown in tissue culture. Positive reactions either for GABA uptake or for AChE content were encountered in pyramidal and stellate, as well as spindle-shaped neurons. Neither reaction was confined to a specific morphological subtype. Nearly half the neurons were negative for either reaction. Most of the remaining neurons were positive only for GABA or only for AChE. However, a subpopulation of neurons showed not only a high AChE content, but also an avid GABA uptake. Thus, four types of neurons could be identified on the basis of these two reactions. The high AChE content in some of the cortical neurons that also showed GABA uptake indicates that there are at least two distinct types of GABAergic neurons.

Gamma aminobutyric acid uptake, release, and effect on36Cl?-influx in bovine pineal gland

1989 ◽  
Vol 77 (2-3) ◽  
pp. 141-152 ◽  
Author(s):  
Ruth E. Rosenstein ◽  
Claudia Sanjurjo ◽  
D. P. Cardinali
Keyword(s):  
Pineal Gland ◽  
Aminobutyric Acid ◽  
Acid Uptake ◽  
Gamma Aminobutyric Acid ◽  
Bovine Pineal Gland

Gamma-aminobutyric acid (GABA) receptor binding selectively depleted by viral induced granule cell loss in hamster cerebellum

1976 ◽  
Vol 105 (2) ◽  
pp. 365-371 ◽  
Author(s):  
Rabi Simantov ◽  
Mary Lou Oster-Granite ◽  
Robert M. Herndon ◽  
Solomon H. Snyder
Keyword(s):  
Receptor Binding ◽  
Granule Cell ◽  
Gaba Receptor ◽  
Cell Loss ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid
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