scholarly journals Transport of sodium and chloride across rat gastric mucosa in vitro.

1985 ◽  
Vol 360 (1) ◽  
pp. 293-310 ◽  
Author(s):  
M J Jackson ◽  
S H Norris
Keyword(s):  
Gastric Mucosa ◽  
Rat Gastric Mucosa

scholarly journals Laminin mediates the restitution of rat gastric mucosa in vitro

1994 ◽  
Vol 79 (5) ◽  
pp. 647-659 ◽  
Author(s):  
MA Miller ◽  
NW Bunnett ◽  
HT Debas
Keyword(s):  
Gastric Mucosa ◽  
Rat Gastric Mucosa

Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1α on the rat gastric mucosa in vivo and in vitro

1978 ◽  
Vol 15 (6) ◽  
pp. 955-967 ◽  
Author(s):  
B.J.R. Whittle ◽  
N.K. Boughton-Smith ◽  
S. Moncada ◽  
J.R. Vane
Keyword(s):  
Gastric Mucosa ◽  
Rat Gastric Mucosa

Calcitonin Gene-Related Peptide (CGRP) Upregulates the Restitution of Rat Gastric Mucosa in Vitro

1995 ◽  
Vol 58 (4) ◽  
pp. 421-424 ◽  
Author(s):  
Craig A. Miller ◽  
Masanobu Nakashima ◽  
George K. Gittes ◽  
Halle T. Debas
Keyword(s):  
Gastric Mucosa ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Rat Gastric Mucosa

scholarly journals Effect of Glucocorticoid on Expression of Rat MUC5AC mRNA in Rat Gastric Mucosa in Vivo and in Vitro.

2001 ◽  
Vol 24 (6) ◽  
pp. 634-637 ◽  
Author(s):  
Toru TANAKA ◽  
Taketo KOBAYASHI ◽  
Kastuyoshi SUNAGA ◽  
Satoru TANI
Keyword(s):  
Gastric Mucosa ◽  
Rat Gastric Mucosa

Sodium-Iodide Symporter Mediates Iodide Secretion in Rat Gastric Mucosa In Vitro

2006 ◽  
Vol 231 (3) ◽  
pp. 277-281 ◽  
Author(s):  
Malin Josefsson ◽  
Lena Evilevitch ◽  
Björn Weström ◽  
Torsten Grunditz ◽  
Eva Ekblad
Keyword(s):  
Gastric Mucosa ◽  
Sodium Iodide ◽  
Sodium Perchlorate ◽  
Nitric Oxide Donor ◽  
Sodium Iodide Symporter ◽  
Iodide Transport ◽  
Gastric Lumen ◽  
Rat Gastric Mucosa ◽  
Mucosal Side

In vivo studies on rats have demonstrated that considerable amounts of iodide are transported from the bloodstream into the gastric lumen. The mechanisms for and functional significance of this transport are poorly understood. Active (driven by Na+/K+-ATPase) iodide transport into thyroid follicular cells is mediated by the sodium-iodide symporter (NIS), which is also abundantly expressed in gastric mucosa. We aimed to further investigate the iodide transport in gastric mucosa and the Possible role of NIS in this transport process. Iodide transport in rat gastric mucosa was studied in vitro in an Ussing chamber system using 125I as a marker. The system allows measurements in both directions over a mucosal specimen. A considerable transport of iodide (from the serosal to the mucosal side) was established across the gastric mucosa, whereas in the opposite direction (mucosa to serosa), iodide transport was negligible. Sodium Perchlorate (NaClO4), a competitive inhibitor of NIS, and ouabain, an inhibitor of the Na+/K+-ATPase, both attenuated gastric iodide transport from the serosal to the mucosal side. To investigate a possible neuroendocrine regulation of the iodide transport identified to occur from the serosal to the mucosal side of the stomach, thyroid-stimulating hormone (TSH), thyrotropin-releasing hormone (TRH), vasoactive intestinal peptide (VIP), histamine, or nitric oxide donor S-nitroso-N-acetyl-D,L-penicillamine (SNAP) was added. None of these substances influenced the iodide transport. We conclude that iodide is actively transported into the gastric lumen and that this transport is at least partly mediated by NIS. Additional investigations are needed to understand the regulation and significance of this transport.

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