Calcitonin Gene-Related Peptide (CGRP) Upregulates the Restitution of Rat Gastric Mucosa in Vitro

1995 ◽  
Vol 58 (4) ◽  
pp. 421-424 ◽  
Author(s):  
Craig A. Miller ◽  
Masanobu Nakashima ◽  
George K. Gittes ◽  
Halle T. Debas
Keyword(s):  
Gastric Mucosa ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Rat Gastric Mucosa

Localization of calcitonin gene-related peptide receptors in rat gastric mucosa

Peptides ◽  
2002 ◽  
Vol 23 (5) ◽  
pp. 955-966 ◽  
Author(s):  
Kousaku Kawashima ◽  
Shunji Ishihara ◽  
Mohammad Azharul Karim Rumi ◽  
Nobuyuki Moriyama ◽  
Hideaki Kazumori ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Calcitonin Gene Related Peptide ◽  
Peptide Receptors ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Rat Gastric Mucosa

Tapentadol inhibits calcitonin gene-related peptide release from rat brainstem in vitro

Peptides ◽  
2014 ◽  
Vol 56 ◽  
pp. 8-13 ◽  
Author(s):  
Maria Cristina Greco ◽  
Lucia Lisi ◽  
Diego Currò ◽  
Pierluigi Navarra ◽  
Giuseppe Tringali
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Peptide Release ◽  
Rat Brainstem

Calcitonin gene-related peptide is a survival factor, inhibiting apoptosis in neonatal rat gubernaculum in vitro

2009 ◽  
Vol 44 (8) ◽  
pp. 1497-1501 ◽  
Author(s):  
Jessica J. Chan ◽  
Pam J. Farmer ◽  
Bridget R. Southwell ◽  
Magdy Sourial ◽  
John M. Hutson
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Neonatal Rat ◽  
Related Peptide ◽  
Survival Factor ◽  
Calcitonin Gene

scholarly journals Renal microvascular actions of calcitonin gene-related peptide

1998 ◽  
Vol 274 (6) ◽  
pp. F1078-F1085 ◽  
Author(s):  
Martina Reslerova ◽  
Rodger Loutzenhiser
Keyword(s):  
Angiotensin Ii ◽  
Rat Kidney ◽  
Elevated Pressure ◽  
Calcitonin Gene Related Peptide ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Renal Vasoconstriction ◽  
Related Peptide ◽  
Calcitonin Gene

Calcitonin gene-related peptide (CGRP) is a potent vasodilator that is suggested to act via ATP-sensitive K channels (KATP). In the present study, we examined the actions of CGRP on pressure- and angiotensin II-induced vasoconstriction, using the in vitro perfused hydronephrotic rat kidney. Elevated pressure (from 80 to 180 mmHg) and 0.1 nM angiotensin II elicited similar decreases in afferent diameter in this model. CGRP inhibited myogenic reactivity in a concentration-dependent manner, completely preventing pressure-induced constriction at 10 nM (95 ± 10% inhibition). These effects were partially attenuated by 10 μM glibenclamide (62 ± 16% inhibition, P = 0.025), indicating both KATP-dependent and -independent actions of CGRP. In contrast, 10 nM CGRP inhibited angiotensin II-induced vasoconstriction by only 54 ± 11%, and this action was not affected by glibenclamide (41 ± 11%, P = 0.31). CGRP also inhibited the efferent arteriolar response to angiotensin II in the absence and presence of glibenclamide. Pinacidil (1.0 μM), a KATP opener also preferentially inhibited pressure- vs. angiotensin II-induced vasoconstriction (97 ± 5 and 59 ± 13% inhibition, respectively; P = 0.034). We conclude that the renal vasodilatory mechanisms of CGRP are pleiotropic and involve both KATP-dependent and -independent pathways. The effectiveness of CGRP in opposing renal vasoconstriction and the role of KATP in this action appear to depend on the nature the underlying vasoconstriction. We suggest that this phenomenon reflects an inhibition of KATP activation by angiotensin II.

Reversal of nerve damage in streptozotocin-diabetic rats by acute application of insulin in vitro

1988 ◽  
Vol 75 (6) ◽  
pp. 629-635 ◽  
Author(s):  
Geoffrey Burnstock ◽  
Rhona Mirsky ◽  
Abebech Belai
Keyword(s):  
Vasoactive Intestinal Polypeptide ◽  
Calcitonin Gene Related Peptide ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Rat Ileum ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Enteric Nerves ◽  
Intestinal Polypeptide

1. Immunohistochemical, immunoblotting and release experiments were performed on ileum from control rats, from 8-week streptozotocin-diabetic rats and from diabetic rats after acute application of insulin in vitro. 2. There was an increase in vasoactive-intestinal-polypeptide-like and a decrease in calcitonin-gene-related-peptide-like immunoreactivity in the myenteric plexus of the diabetic rat ileum, although electrically evoked release of both peptides from enteric nerves was defective. Acute application of insulin in vitro reversed the defective release and changes in immunoreactivity of vasoactive intestinal polypeptide and calcitonin-gene-related peptide seen in the enteric nerves of streptozotocin-diabetic rat ileum. 3. In addition, using a monoclonal neurofilament antibody RT 97 that recognizes a phosphorylated neurofilament epitope present in normal enteric nerves, it was shown that this phosphorylated neurofilament epitope was absent in diabetic nerves, even though a polyclonal neurofilament antibody revealed that neurofilaments were present in both axons and cell bodies of the myenteric plexus of diabetic rat ileum. After only 2 h of insulin incubation in vitro, the phosphorylated neurofilament epitope was again present in the nerves. 4. It is suggested that the abnormal distribution of phosphorylated neurofilaments and defective storage and release of vasoactive intestinal polypeptide and calcitonin-gene-related peptide in the present study may be a more general feature of diabetes. The restoration of these abnormalities by continuous acute insulin application in vitro shown here suggests that the availability of a steady level of insulin might prevent some of the changes which occur in early stages of diabetes. If so, this could influence the use of insulin in the treatment of diabetes, particularly in view of the recent report that short-term continuous subcutaneous insulin infusion restores the function of the autonomic and peripheral nerves in type I diabetic patients [Krönert, K., Hülsen, J., Luft, D., Stetter, T. & Eggstein, M. (1987) Journal of Clinical Endocrinology and Metabolism, 64, 1219–1223].

Flupirtine inhibits calcitonin-gene related peptide release from rat brainstem in vitro

2012 ◽  
Vol 506 (2) ◽  
pp. 332-335 ◽  
Author(s):  
Giuseppe Tringali ◽  
Maria Cristina Greco ◽  
Alessandro Capuano ◽  
Giuseppe Guerriero ◽  
Diego Currò ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Peptide Release ◽  
Rat Brainstem
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