scholarly journals Persistent slow inward calcium current in voltage-clamped hippocampal neurones of the guinea-pig.

1983 ◽  
Vol 337 (1) ◽  
pp. 303-320 ◽  
Author(s):  
D A Brown ◽  
W H Griffith
Keyword(s):  
Guinea Pig ◽  
Calcium Current ◽  
Slow Inward Calcium Current

scholarly journals Modulation of guinea-pig cardiac L-type calcium current by nitric oxide synthase inhibitors

1998 ◽  
Vol 506 (3) ◽  
pp. 639-651 ◽  
Author(s):  
Maria Pia Gallo ◽  
Dario Ghigo ◽  
Amalia Bosia ◽  
Giuseppe Alloatti ◽  
Costanzo Costamagna ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Guinea Pig ◽  
Calcium Current ◽  
Nitric Oxide Synthase Inhibitors ◽  
Oxide Synthase

Low-Voltage Activated T-Type Calcium Currents Are Differently Expressed in Superficial and Deep Layers of Guinea PigPiriform Cortex

1998 ◽  
Vol 79 (2) ◽  
pp. 808-816 ◽  
Author(s):  
Jacopo Magistretti ◽  
Marco de Curtis
Keyword(s):  
Guinea Pig ◽  
Calcium Current ◽  
Low Voltage ◽  
Piriform Cortex ◽  
Neuronal Firing ◽  
Calcium Currents ◽  
Patch Clamp Technique ◽  
Voltage Range ◽  
Deep Layers ◽  
Group 2

Magistretti, Jacopo and Marco de Curtis. Low-voltage activated T-type calcium currents are differently expressed in superficial and deep layers of guinea pig piriform cortex. J. Neurophysiol. 79: 808–816, 1998. A variety of voltage-dependent calcium conductances are known to control neuronal excitability by boosting peripheral synaptic potentials and by shaping neuronal firing patterns. The existence and functional significance of a differential expression of low- and high-voltage activated (LVA and HVA, respectively) calcium currents in subpopulations of neurons, acutely isolated from different layers of the guinea pig piriform cortex, were investigated with the whole cell variant of the patch-clamp technique. Calcium currents were recorded from pyramidal and multipolar neurons dissociated from layers II, III, and IV. Average membrane capacitance was larger in layer IV cells [13.1 ± 6.2 (SD) pF] than in neurons from layers II and III (8.6 ± 2.8 and 7.9 ± 3.1 pF, respectively). Neurons from all layers showed HVA calcium currents with an activation voltage range positive to −40 mV. Neurons dissociated from layers III and IV showed an LVA calcium current with the biophysical properties of a T-type conductance. Such a current displayed the following characteristics: 1) showed maximal amplitude of 11–16 pA/pF at −30 mV, 2) inactivated rapidly with a time constant of ∼22 ms at −30 mV, and 3) was completely steady-state inactivated at −60 mV. Only a subpopulation of layer II neurons (group 2 cells; circa 18%) displayed an LVA calcium current similar to that observed in deep layers. The general properties of layer II-group 2 cells were otherwise identical to those of group 1 neurons. The present study demonstrates that LVA calcium currents are differentially expressed in neurons acutely dissociated from distinct layers of the guinea pig piriform cortex.

scholarly journals The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes

1999 ◽  
Vol 126 (7) ◽  
pp. 1531-1533 ◽  
Author(s):  
George P Thomas ◽  
Morris Karmazyn ◽  
Andrew C Zygmunt ◽  
Charles Antzelevitch ◽  
Njanoor Narayanan
Keyword(s):  
Guinea Pig ◽  
Calcium Current ◽  
Ventricular Myocytes ◽  
Antifungal Antibiotic

Cyclic AMP and cyclic GMP independent stimulation of ventricular calcium current by peroxynitrite donors in guinea pig myocytes

2003 ◽  
Vol 197 (2) ◽  
pp. 284-296 ◽  
Author(s):  
Daniela Malan ◽  
Renzo Cesare Levi ◽  
Giuseppe Alloatti ◽  
Andrea Marcantoni ◽  
Ivano Bedendi ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Guinea Pig ◽  
Cyclic Gmp ◽  
Calcium Current ◽  
Stimulation Of
Sign in / Sign up

Export Citation Format

Share Document