scholarly journals Stimulation-dependent facilitation of the high threshold calcium current in guinea-pig ventricular myocytes.

1990 ◽  
Vol 428 (1) ◽  
pp. 653-671 ◽  
Author(s):  
A C Zygmunt ◽  
J Maylie
Keyword(s):  
Guinea Pig ◽  
Calcium Current ◽  
Ventricular Myocytes ◽  
High Threshold

scholarly journals The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes

1999 ◽  
Vol 126 (7) ◽  
pp. 1531-1533 ◽  
Author(s):  
George P Thomas ◽  
Morris Karmazyn ◽  
Andrew C Zygmunt ◽  
Charles Antzelevitch ◽  
Njanoor Narayanan
Keyword(s):  
Guinea Pig ◽  
Calcium Current ◽  
Ventricular Myocytes ◽  
Antifungal Antibiotic

Stimulatory effect of ouabain on T- and L-type calcium currents in guinea pig cardiac myocytes

1990 ◽  
Vol 258 (5) ◽  
pp. H1620-H1623 ◽  
Author(s):  
B. Le Grand ◽  
E. Deroubaix ◽  
A. Coulombe ◽  
E. Coraboeuf
Keyword(s):  
Steady State ◽  
Guinea Pig ◽  
Ventricular Myocytes ◽  
Calcium Currents ◽  
High Threshold ◽  
Inactivation Curve ◽  
Cell Recording ◽  
Steady State Inactivation ◽  
Low Threshold ◽  
Free Media

The effect of 10(-6) M ouabain on macroscopic low-threshold T-type Ca2+ and high-threshold L-type Ca2+ currents was studied by whole cell recording in isolated guinea pig ventricular myocytes superfused with K-free, Na-free media, i.e., after suppression of Na-K-ATPase activity and Na influx through the Na-Ca exchanger. Under such conditions, the amplitudes of the two currents were significantly increased by ouabain. In particular, the current occurring in the -50 to -20 mV range (T-type Ca2+) was increased two- to threefold by ouabain and suppressed by 40 microM Ni2+. Ouabain shifted by approximately 10 mV toward negative potentials the steady-state inactivation curve of the T-type Ca2+ current but not that of the L-type Ca2+ current. It is concluded that ouabain enhances not only L-type Ca2+ current but also T-type Ca2+ current possibly through different mechanisms.

scholarly journals Inhibition of cyclic GMP hydrolysis with zaprinast reduces basal and cyclic AMP-elevated L-type calcium current in guinea-pig ventricular myocytes

2003 ◽  
Vol 138 (5) ◽  
pp. 986-994 ◽  
Author(s):  
Mark T Ziolo ◽  
Susanne J Lewandowski ◽  
Jacquelyn M Smith ◽  
Fred D Romano ◽  
Gordon M Wahler
Keyword(s):  
Cyclic Amp ◽  
Guinea Pig ◽  
Cyclic Gmp ◽  
Calcium Current ◽  
Ventricular Myocytes

scholarly journals Effects of propafenone on calcium current in guinea-pig ventricular myocytes

1993 ◽  
Vol 108 (3) ◽  
pp. 721-727 ◽  
Author(s):  
C. Delgado ◽  
J. Tamargo ◽  
D. Henzel ◽  
P. Lorente
Keyword(s):  
Guinea Pig ◽  
Calcium Current ◽  
Ventricular Myocytes
Sign in / Sign up

Export Citation Format

Share Document