scholarly journals Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age

1978 ◽  
Vol 274 (1) ◽  
pp. 621-637 ◽  
Author(s):  
G. Sundlöf ◽  
B. G. Wallin
Keyword(s):  
Blood Pressure ◽  
Sympathetic Activity ◽  
Human Muscle ◽  
Muscle Nerve

scholarly journals Possible genetic influence on the strength of human muscle nerve sympathetic activity at rest.

Hypertension ◽  
1993 ◽  
Vol 22 (3) ◽  
pp. 282-284 ◽  
Author(s):  
B G Wallin ◽  
M M Kunimoto ◽  
J Sellgren
Keyword(s):  
Sympathetic Activity ◽  
Human Muscle ◽  
Genetic Influence ◽  
Muscle Nerve

Muscle–Nerve Sympathetic Activity in Man. Relationship to Blood Pressure in Resting Normo- and Hyper-Tensive Subjects

1978 ◽  
Vol 55 (s4) ◽  
pp. 387s-389s ◽  
Author(s):  
G. Sundlöf ◽  
B. G. Wallin
Keyword(s):  
Blood Pressure ◽  
Negative Correlation ◽  
Sympathetic Activity ◽  
Diastolic Pressure ◽  
Pressure Fluctuations ◽  
Blood Pressure Level ◽  
Heart Beat ◽  
Arterial Blood ◽  
Muscle Nerve ◽  
Pressure Changes

1. Simultaneous recordings of multi-unit muscle nerve sympathetic activity and arterial blood pressure were made in 29 subjects, 17 healthy and 12 hypertensive. The neural activity, quantified by counting the number of pulse-synchronous sympathetic bursts in the mean voltage neurogram (burst incidence), was plotted against blood pressure. The effect of spontaneous temporary blood pressure fluctuations was studied by correlating different pressure parameters of individual heart beats to the occurrence of a sympathetic burst. 2. Between subjects there were marked differences in burst incidence but no correlation was found to interindividual differences in blood pressure level. 3. When for each heart beat the occurrence of a burst was correlated to different pressure parameters there was a close negative correlation to diastolic, a low correlation to systolic, and an intermediate negative correlation to mean blood pressure. 4. In a given subject, when comparing heart beats with the same diastolic pressure, the occurrence and the amplitudes of the sympathetic bursts were higher during falling than during rising pressure. This directional dependence of the muscle—nerve sympathetic activity was slightly more pronounced in the hypertensive group, but this was considered secondary to the hypertension. 5. The findings of an intimate correlation with dynamic variations in blood pressure and the absence of correlation to the static blood pressure suggest that the sympathetic outflow to skeletal muscle is of importance for buffering acute blood pressure changes but has little influence on the long-term blood pressure.

Increase in Muscle Nerve Sympathetic Activity in Humans after Food Intake

1994 ◽  
Vol 86 (2) ◽  
pp. 159-167 ◽  
Author(s):  
JAN Fagius ◽  
Christian Berne
Keyword(s):  
Blood Pressure ◽  
Food Intake ◽  
Sympathetic Activity ◽  
Insulin Response ◽  
Mixed Meal ◽  
Muscle Nerve ◽  
Intermediate Response ◽  
Normotensive Subjects ◽  
Pressure Changes ◽  
Effect Of Glucose

1. The influence of the intake of different nutrients on muscle nerve sympathetic activity was studied by use of microneurography. Muscle nerve sympathetic activity, heart rate, blood pressure and the insulin response were monitored for 90 min in 39 healthy, lean, normotensive subjects (mean age 26 years) who received 100 g of glucose in 300 ml of water (n = 8), 50 g of fat in 250 ml of water (n = 8), 100 g of lean meat corresponding to 40 g of protein with 250 ml of water (n = 8), 300 ml of water only (n = 7) or a mixed meal (1750 kJ) (n = 8). 2. All types of food evoked an increase in muscle nerve sympathetic activity whereas water caused no change. The increase in muscle nerve sympathetic activity was already significant at 15–30 min and was still strongly significant at 90 min. The effect of glucose was significantly greater than that of fat and protein; the mixed meal caused an intermediate response. Blood pressure changes were minor. 3. It is concluded that a sustained increase in muscle nerve sympathetic activity occurs regularly after any type of food intake. A rise in muscle nerve sympathetic activity takes place in the absence of an insulin response, and insulin contributes to only part of the increase after ingestion of glucose or a mixed meal. The muscle nerve sympathetic activity response is thought to be of importance for the redistribution of blood to the splanchnic region after a meal. Lack of this response is likely to explain postprandial hypotension in autonomic failure.

Autonomic control of vasovagal syncope

1998 ◽  
Vol 274 (6) ◽  
pp. H2110-H2115 ◽  
Author(s):  
David L. Jardine ◽  
Hamid Ikram ◽  
Christopher M. Frampton ◽  
Rachell Frethey ◽  
Sinclair I. Bennett ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Flow ◽  
Sympathetic Activity ◽  
Forearm Blood Flow ◽  
Vasovagal Syncope ◽  
Cardiac Activity ◽  
Baroreceptor Sensitivity ◽  
Head Up Tilt ◽  
Muscle Nerve

In the pathophysiological study of vasovagal syncope, the nature of the interaction between baroreceptor sensitivity (BS), sympathetic withdrawal, and parasympathetic activity has yet to be ascertained. Altered BS may predispose toward abnormal sympathetic and parasympathetic responses to orthostasis, causing hypotension that may progress to syncope if there is sympathetic withdrawal. To examine this hypothesis, we monitored blood pressure (BP), heart rate (HR), BS, forearm blood flow, and muscle nerve sympathetic activity (MNSA) continuously in 18 vasovagal patients during 60° head-up tilt, syncope, and recovery. Results were compared with those of 17 patients who were able to tolerate tilt for 45 min. During early tilt, BP was maintained in both groups by an increase in HR and MNSA from baseline ( P < 0.01), but BS decreased more in the syncopal group ( P < 0.05). At the start of presyncope (mean 2.7 ± 0.2 min before syncope and 15.2 ± 12 min after tilt), when BP fell, HR and sympathetic activity remained increased from baseline ( P< 0.01). Thereafter, BP and HR correlated directly with sympathetic activity and regressed in linear fashion until syncope ( P < 0.001), whereas BS increased to baseline. At syncope, BP, HR, and sympathetic activity fell below baseline ( P < 0.01, P < 0.05, and P < 0.01, respectively), but BS did not increase. During recovery, sympathetic activity increased to baseline and BS increased ( P < 0.05), whereas HR and BP remained low ( P < 0.01 and P < 0.05, respectively). The mechanism for the initiation of hypotension during presyncope remains unknown, but BS may contribute. Vasodilatation and bradycardia during presyncope appear to be more closely related to withdrawal of sympathetic activity than to increased parasympathetic cardiac activity.

scholarly journals Post-Exertional Malaise May Be Related to Central Blood Pressure, Sympathetic Activity and Mental Fatigue in Chronic Fatigue Syndrome Patients

2021 ◽  
Vol 10 (11) ◽  
pp. 2327
Author(s):  
Sławomir Kujawski ◽  
Joanna Słomko ◽  
Lynette Hodges ◽  
Derek F. H. Pheby ◽  
Modra Murovska ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Chronic Fatigue Syndrome ◽  
Systolic Blood Pressure ◽  
Sympathetic Activity ◽  
Chronic Fatigue ◽  
Mental Fatigue ◽  
Fatigue Syndrome ◽  
Central Systolic Blood Pressure

Post-exertional malaise (PEM) is regarded as the hallmark symptom in chronic fatigue syndrome (CFS). The aim of the current study is to explore differences in CFS patients with and without PEM in indicators of aortic stiffness, autonomic nervous system function, and severity of fatigue. One-hundred and one patients met the Fukuda criteria. A Chronic Fatigue Questionnaire (CFQ) and Fatigue Impact Scale (FIS) were used to assess the level of mental and physical fatigue. Aortic systolic blood pressure (sBPaortic) and the autonomic nervous system were measured with the arteriograph and Task Force Monitor, respectively. Eighty-two patients suffered prolonged PEM according to the Fukuda criteria, while 19 did not. Patients with PEM had higher FIS scores (p = 0.02), lower central systolic blood pressure (p = 0.02) and higher mental fatigue (p = 0.03). For a one-point increase in the mental fatigue component of the CFQ scale, the risk of PEM increases by 34%. For an sBPaortic increase of 1 mmHg, the risk of PEM decreases by 5%. For a one unit increase in sympathovagal balance, the risk of PEM increases by 330%. Higher mental fatigue and sympathetic activity in rest are related to an increased risk of PEM, while higher central systolic blood pressure is related to a reduced risk of PEM. However, none of the between group differences were significant after FDR correction, and therefore conclusions should be treated with caution and replicated in further studies.

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