scholarly journals Action potentials in slow muscle fibres of the frog during regeneration of motor nerves.

1977 ◽  
Vol 270 (2) ◽  
pp. 507-517 ◽  
Author(s):  
H Schmidt ◽  
E Stefani
1985 ◽  
Vol 60 (6) ◽  
pp. 539-547 ◽  
Author(s):  
Willemien Wallinga-De Jonge ◽  
Frans L.H Gielen ◽  
Peter Wirtz ◽  
Paul De Jong ◽  
Jan Broenink

Pyriformis muscles of the frog were denervated by section of the sciatic nerve. About three weeks later all slow muscle fibres examined had become capable of generating action potentials. However, the action potential mechanism failed to develop if actinomycin D was injected early after the operation. It is suggested that RNA synthesis is required for the formation of ‘Na channels’ in the membrane of denervated slow muscle fibres.


Nature ◽  
1975 ◽  
Vol 253 (5487) ◽  
pp. 122-123 ◽  
Author(s):  
G. SCHALOW ◽  
H. SCHMIDT

1980 ◽  
Vol 299 (1) ◽  
pp. 197-202 ◽  
Author(s):  
S G Cull-Candy ◽  
R Miledi ◽  
O D Uchitel

1981 ◽  
Vol 213 (1191) ◽  
pp. 243-248 ◽  

Slow muscle fibres in the frog are normally incapable of generating action potentials. However, several days after an intramuscular injection of α-bungarotoxin, they acquire the ability to generate action potentials. It appears that α-bungarotoxin induces the action potential mechanism in slow fibres because it blocks acetylcholine receptors, and thus interferes with the action of non-quantal acetylcholine leaking from nerve terminals, or because the toxin has some other, as yet undefined, action on nerve or muscle.


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