scholarly journals Compensatory renal growth after unilateral nephrectomy in the new-born rat

1973 ◽  
Vol 228 (1) ◽  
pp. 193-202 ◽  
Author(s):  
S. E. Dicker ◽  
D. G. Shirley
Keyword(s):  
Unilateral Nephrectomy ◽  
Renal Growth ◽  
Compensatory Renal Growth ◽  
New Born

Early increase in pulsatile growth hormone release after unilateral nephrectomy in adult rats

1994 ◽  
Vol 266 (4) ◽  
pp. F628-F632 ◽  
Author(s):  
A. Haramati ◽  
M. D. Lumpkin ◽  
S. E. Mulroney
Keyword(s):  
Growth Hormone ◽  
Early Time ◽  
Peak Level ◽  
Unilateral Nephrectomy ◽  
Sham Operation ◽  
Renal Growth ◽  
Adult Rats ◽  
Compensatory Renal Growth ◽  
Jugular Veins ◽  
Hypertrophic Response

Removal of one kidney results, within days, in accelerated growth of the remaining kidney. However, the mechanisms that underlie this compensatory renal hypertrophic response, particularly in the early time period following nephrectomy, are not understood. In this study we tested the hypothesis that removal of one kidney leads to a change in the pulsatile release of growth hormone (GH), which facilitates compensatory renal growth. Adult Wistar rats were implanted with Silastic cannulas in jugular veins and underwent either unilateral nephrectomy (UNX) or sham operation. Plasma levels of GH were determined 24 and 48 h after sham operation or UNX. Blood samples were taken every 20 min over a 6-h period from conscious, unrestrained animals. Pulsatile GH release was markedly elevated 24 h after UNX in both the amplitude of the surges as well as in the duration of release. Peak GH levels after 24 h were three- to fourfold higher in UNX rats compared with sham controls (417 +/- 75 vs. 119 +/- 23 ng/ml, P < 0.05). However, this enhanced release of GH appeared to be of short duration and began declining by 48 h post-UNX (peak level of 227 +/- 37 ng/ml, P < 0.05 vs. both 24 h UNX and sham controls). To examine whether this rise in GH release post-UNX contributed to the compensatory renal growth, rats underwent UNX and were immediately treated with an antagonist to GH-releasing factor (GRF-AN; i.e., [N-Ac-Tyr1,D-Arg2]GRF-(1-29) amide, 200 micrograms/kg twice daily), and the effects on GH release and renal growth were determined. Administration of GRF-AN significantly suppressed the increase in GH release post-UNX and was associated with a significant attenuation in renal growth 48 h post-UNX in GRF-AN-treated rats (8.7 +/- 2.6% vs. 22.7 +/- 3.0% in UNX controls, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Compensatory Renal Growth after Unilateral Nephrectomy in the Ovine Fetus

2002 ◽  
Vol 13 (2) ◽  
pp. 406-410 ◽  
Author(s):  
Rebecca Douglas-Denton ◽  
Karen M. Moritz ◽  
John F. Bertram ◽  
E. Marelyn Wintour
Keyword(s):  
Compensatory Growth ◽  
Weight Ratio ◽  
In Utero ◽  
Unilateral Nephrectomy ◽  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Glomerular Volume ◽  
Ovine Fetus ◽  
Wet Weight ◽  
The Right

ABSTRACT. Unilateral nephrectomy of the adult animal results in compensatory renal growth but does not involve formation of new nephrons. It is not clear whether compensatory growth can occur during the period of active nephrogenesis in utero and if so, whether more nephrons can be formed. Male ovine fetuses (n = 20) underwent unilateral nephrectomy (n = 10) or sham nephrectomy (n = 10) at 100 d of gestation (term, 150 d). After 27 to 34 d, ewes and fetuses were killed and the right kidney of each fetus was removed and weighed. The wet weight of the right kidney was greater in the unilaterally nephrectomized fetuses (16.3 ± 1.3 g compared with 12.2 ± 0.7 g; mean ± SEM, P < 0.05) as was the kidney to body weight ratio (5.2 ± 0.3 g/kg compared with 3.8 ± 0.2 g/kg; P < 0.001). Nephron number in the right kidney was estimated by an unbiased stereologic technique. There was a 45% increase in the number of nephrons in the kidneys from unilaterally nephrectomized animals compared with the kidneys from sham-operated animals (530,763 ± 37,136 nephrons in the unilaterally nephrectomized group compared with 365,672 ± 36,016 nephrons in the sham-operated group; P < 0.01). Mean glomerular volume was lower in the unilaterally nephrectomized group; however, total glomerular volume per kidney was not different between groups. This study demonstrates that there is a significant amount of compensatory growth and nephron endowment in a remaining kidney after unilateral nephrectomy during the period of active nephrogenesis in the sheep. This is the first time such events have been shown to occur in utero.

Influence of age on deterioration of the remnant kidney in uninephrectomized rats

1987 ◽  
Vol 72 (5) ◽  
pp. 571-576 ◽  
Author(s):  
Seiya Okuda ◽  
Kenichi Motomura ◽  
Tohru Sanai ◽  
Hiroshi Tsuruda ◽  
Yukinori Oh ◽  
...  
Keyword(s):  
Urinary Protein ◽  
Unilateral Nephrectomy ◽  
Glomerular Sclerosis ◽  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Characteristic Finding ◽  
Significant Difference ◽  
Renal Histology ◽  
Segmental Glomerular Sclerosis ◽  
Remnant Kidney

1. To investigate the influence of age on the remnant kidney, unilateral nephrectomy was performed in rats at 1 day (group N-0), 2 weeks (group N-2), 4 weeks (group N-4) or 8 weeks (group N-8) of age. Serial changes in urinary protein during 48 weeks after the uninephrectomy and blood chemistries and renal histology at week 48 were compared between the groups. 2. The increase in proteinuria was significantly greater in groups N-0, N-2 and N-4 than in group N-8 from week 32 to week 48 after the uninephrectomy. There was no significant difference in urinary protein between groups N-0, N-2 and N-4. Hypoproteinaemia and hypoalbuminaemia were also more severe in groups N-0, N-2 and N-4 than in group N-8 at week 48. 3. A compensatory renal growth in groups N-0 and N-4 was significantly greater than that in group N-8 at week 48 after the uninephrectomy. 4. Focal and segmental glomerular sclerosis, a characteristic finding in the uninephrectomy groups, was significantly more marked in groups N-0, N-2 and N-4 than in group N-8 at week 48. 5. We conclude that uninephrectomy at young ages leads to increased incidence of glomerular sclerosis in rats compared with uninephrectomy in the adult.

Peritubular endothelial cell proliferation in mice during compensatory renal growth after unilateral nephrectomy

1993 ◽  
Vol 265 (5) ◽  
pp. F712-F716 ◽  
Author(s):  
S. Kanda ◽  
H. Hisamatsu ◽  
T. Igawa ◽  
J. Eguchi ◽  
M. Taide ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Regulation ◽  
Significant Inhibition ◽  
Labeling Index ◽  
Unilateral Nephrectomy ◽  
Endothelial Cell Proliferation ◽  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Inhibition Of Proliferation ◽  
Tubular Cells

The proliferation of peritubular endothelial cells during compensatory renal growth (CRG) following unilateral nephrectomy in mice was investigated using a labeling index. The labeling index of peritubular endothelial cells increased 6 h after uninephrectomy and decreased to the normal level within 72 h. Immunohistochemical study revealed that c-myc protein was expressed in the nuclei of both cortical tubular cells and peritubular endothelial cells. Furthermore, intravenous injection of anti-basic fibroblast growth factor (bFGF) neutralizing antibody just after uninephrectomy led to significant inhibition of proliferation of peritubular endothelial cells, but not tubular cells. These results indicate that peritubular endothelial cells proliferate transiently during CRG and that bFGF plays an important role for the growth regulation of that cell in the kidney.

CT Evaluation of Compensatory Renal Growth in Relation to Postnephrectomy Time

1992 ◽  
Vol 33 (6) ◽  
pp. 566-568 ◽  
Author(s):  
P. Prassopoulos ◽  
N. Gourtsoyiannis ◽  
D. Cavouras ◽  
N. Pantelidis
Keyword(s):  
Renal Carcinoma ◽  
Compensatory Hypertrophy ◽  
Renal Parenchyma ◽  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Kidney Size ◽  
Before And After ◽  
Ct Evaluation ◽  
Multiple Measurements ◽  
Parenchymal Thickness

In 27 patients nephrectoraized for renal carcinoma, the compensatory hypertrophy of the remaining kidney was assessed by 72 CT examinations performed one month before and during 32 months after nephrectomy. Kidney size was estimated on CT by multiple measurements of the renal parenchymal thickness. Kidney growth was evaluated by comparing the amount of renal parenchyma before and after contralateral nephrectomy. Renal compensatory hypertrophy varied with postnephrectomy time. Kidney enlargement was 15% in the first 3 months, reached maximum 30% about a year later, and was reduced to 5%, 2 1/2 years postoperatively.

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