scholarly journals Acidic pH reduces agonist efficacy and responses to synaptic‐like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors

2021 ◽  
Author(s):  
Josip Ivica ◽  
Remigijus Lape ◽  
Lucia G. Sivilotti
Keyword(s):  
Acidic Ph ◽  
Glycine Receptors

Kinetic Adsorption of Humic Acids Mixture Obtained from Microalgae on Exfoliated Graphite Nanoplatelets

2018 ◽  
Vol 69 (1) ◽  
pp. 191-195
Author(s):  
Elena Radu ◽  
Elena Emilia Oprescu ◽  
Cristina Emanuela Enascuta ◽  
Catalina Calin ◽  
Rusandica Stoica ◽  
...  
Keyword(s):  
Humic Acid ◽  
Humic Acids ◽  
Alkali Treatment ◽  
Exfoliated Graphite ◽  
Acid Mixture ◽  
Acidic Ph ◽  
Graphite Nanoplatelets ◽  
Mixture Concentration ◽  
Ft Ir ◽  
Exfoliated Graphite Nanoplatelets

The dehydration of polysaccharides fraction in the presence of acid catalysts, is a chemical process in which results as secondary product humic matter. In our work, the humic acid mixture was for the first time based on our knowledge extracted from defatted microalgae biomass rich in polysaccharides by standard alkali treatment, followed by precipitation at acidic pH. The dried humic acid mixture has been characterized using infrared spectroscopic measurements (FT-IR). Exfoliated graphite nanoplatelets (xGnP) were used as new adsorbents for this type of humic acids mixture, their adsorption being investigated. The effect of several parameters such as: contact time, concentration of humic acid mixture, concentration of xGnP, temperature and pH of the solutions were studied. The process of adsorption took place with good results, in the following conditions: at a concentration of humic acid mixture of 18.6 mg L-1, an xGnP amount of 0.01 mg in 25 mL of solution, at a temperature of 25 �� and at acidic pH values, in aqueous solution.

Is the Acidic pH of the External Auditory Canal Playing a Significant Role in the Treatment of Acute Otitis Externa?

2018 ◽  
Vol 69 (8) ◽  
pp. 2304-2305
Author(s):  
Oana Ruxandra Iana ◽  
Dragos Cristian Stefanescu ◽  
Viorel Zainea ◽  
Razvan Hainarosie
Keyword(s):  
External Auditory Canal ◽  
Otitis Externa ◽  
Proton Pumps ◽  
Acidic Ph ◽  
External Ear ◽  
Ph Values ◽  
The World ◽  
Subcutaneous Tissues ◽  
Low Levels ◽  
Value Changes

Variable pH values for skin have been reported in the literature, all within the acidic range, varying from 4.0 up to 7. 0. The origin of the acidic pH remains conjectural, and several factors have been incriminated with this role, such as eccrine and sebaceous secretions as well as proton pumps. Keeping low levels of pH prevents microbial dispersal as well as multiplication. The skin in the external auditory canal is also covered with this acidic mantle with antimicrobial value. Changes of pH in the external ear can lead to acute otitis externa. This condition is defined by the inflammation and infection of the cutaneous and subcutaneous tissues of the external auditory canal. 10% of the world�s population may suffer from acute otitis externa at least once in their lifetime. This paper aims to consolidate the relevance of an acidic pH in the healthy external ear and its relation to the pathogenesis and treatment of otitis externa through a prospective and interventional clinical study on 80 patients who presented to the outpatient department at Prof. Dr D. Hociota ENT Institute in Buch

Synthesis and 31 P NMR characterization of new low toxic highly sensitive pH probes designed for in vivo acidic pH studies

2002 ◽  
Vol 10 (5) ◽  
pp. 1451-1458 ◽  
Author(s):  
Sophie Martel ◽  
Jean-Louis Clément ◽  
Agnès Muller ◽  
Marcel Culcasi ◽  
Sylvia Pietri
Keyword(s):  
Acidic Ph ◽  
Highly Sensitive ◽  
Nmr Characterization ◽  
Low Toxic ◽  
Ph Probes

scholarly journals Signal Transduction and Regulatory Mechanisms Involved in Control of the σS (RpoS) Subunit of RNA Polymerase

2002 ◽  
Vol 66 (3) ◽  
pp. 373-395 ◽  
Author(s):  
Regine Hengge-Aronis
Keyword(s):  
Rna Polymerase ◽  
Translational Control ◽  
Current Knowledge ◽  
Response Regulator ◽  
Regulatory System ◽  
Stress Conditions ◽  
Acidic Ph ◽  
High Osmolarity ◽  
Multiple Signal ◽  
Rpos Mrna

SUMMARY The σS (RpoS) subunit of RNA polymerase is the master regulator of the general stress response in Escherichia coli and related bacteria. While rapidly growing cells contain very little σS, exposure to many different stress conditions results in rapid and strong σS induction. Consequently, transcription of numerous σS-dependent genes is activated, many of which encode gene products with stress-protective functions. Multiple signal integration in the control of the cellular σS level is achieved by rpoS transcriptional and translational control as well as by regulated σS proteolysis, with various stress conditions differentially affecting these levels of σS control. Thus, a reduced growth rate results in increased rpoS transcription whereas high osmolarity, low temperature, acidic pH, and some late-log-phase signals stimulate the translation of already present rpoS mRNA. In addition, carbon starvation, high osmolarity, acidic pH, and high temperature result in stabilization of σS, which, under nonstress conditions, is degraded with a half-life of one to several minutes. Important cis-regulatory determinants as well as trans-acting regulatory factors involved at all levels of σS regulation have been identified. rpoS translation is controlled by several proteins (Hfq and HU) and small regulatory RNAs that probably affect the secondary structure of rpoS mRNA. For σS proteolysis, the response regulator RssB is essential. RssB is a specific direct σS recognition factor, whose affinity for σS is modulated by phosphorylation of its receiver domain. RssB delivers σS to the ClpXP protease, where σS is unfolded and completely degraded. This review summarizes our current knowledge about the molecular functions and interactions of these components and tries to establish a framework for further research on the mode of multiple signal input into this complex regulatory system.

NMDA-coupled periaqueductal gray glycine receptors modulate anxioselective drug effects on plus-maze performance

1998 ◽  
Vol 90 (2) ◽  
pp. 157-165 ◽  
Author(s):  
Márcia Maria De Souza ◽  
Luiz Carlos Schenberg ◽  
Antonio de Pádua Carobrez
Keyword(s):  
Drug Effects ◽  
Periaqueductal Gray ◽  
Maze Performance ◽  
Glycine Receptors ◽  
Plus Maze

scholarly journals Presence of ethanol sensitive and insensitive glycine receptors in the ventral tegmental area and prefrontal cortex in mice

2021 ◽  
Author(s):  
Anibal Araya ◽  
Scarlet Gallegos ◽  
Rodrigo Viveros ◽  
Loreto San Martin ◽  
Braulio Muñoz ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Ventral Tegmental Area ◽  
Glycine Receptors ◽  
Ventral Tegmental
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