scholarly journals Acute reductions in haematocrit increase flow‐mediated dilatation independent of resting nitric oxide bioavailability in humans

2020 ◽  
Vol 598 (19) ◽  
pp. 4225-4236 ◽  
Author(s):  
Ryan L. Hoiland ◽  
Joshua C. Tremblay ◽  
Benjamin S. Stacey ◽  
Geoff B. Coombs ◽  
Daniela Nowak‐Flück ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Flow Mediated Dilatation ◽  
Nitric Oxide Bioavailability

Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability

2021 ◽  
Author(s):  
Gustavo H. Oliveira-Paula ◽  
Fernanda Borchers Coeli-Lacchini ◽  
Letícia Perticarrara Ferezin ◽  
Graziele C. Ferreira ◽  
Lucas C. Pinheiro ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Arginase Ii ◽  
Nitric Oxide Bioavailability

Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide

2001 ◽  
Vol 101 (6) ◽  
pp. 629-635 ◽  
Author(s):  
Sagar N. DOSHI ◽  
Katerina K. NAKA ◽  
Nicola PAYNE ◽  
Christopher J.H. JONES ◽  
Moira ASHTON ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Function ◽  
Brachial Artery ◽  
Peak Flow ◽  
Ultrasound Probe ◽  
Upper Arm ◽  
Flow Mediated Dilatation ◽  
Synthase Inhibitor ◽  
Increased Blood Flow ◽  
Similar Peak

Flow-mediated dilatation (FMD) of the brachial artery assessed by high-resolution ultrasound is widely used to measure endothelial function. However, the technique is not standardized, with different groups using occlusion of either the wrist or the upper arm to induce increased blood flow. The validity of the test as a marker of endothelial function rests on the assumption that the dilatation observed is endothelium-dependent and mediated by nitric oxide (NO). We sought to compare the NO component of brachial artery dilatation observed following wrist or upper arm occlusion. Dilatation was assessed before and during intra-arterial infusion of the NO synthase inhibitor NG-monomethyl-l-arginine (l-NMMA) following occlusion of (i) the wrist (distal to ultrasound probe) and (ii) the upper arm (proximal to ultrasound probe) for 5min in ten healthy males. Dilatation was significantly greater after upper arm occlusion (upper arm, 11.62±3.17%; wrist, 7.25±2.49%; P = 0.003). During l-NMMA infusion, dilatation after wrist occlusion was abolished (from 7.25±2.49% to 0.16±2.24%; P < 0.001), whereas dilatation after upper arm occlusion was only partially attenuated (from 11.62±3.17% to 7.51±2.34%; P = 0.006). The peak flow stimulus was similar after wrist and upper arm occlusion. We conclude that dilatation following upper arm occlusion is greater than that observed after wrist occlusion, despite a similar peak flow stimulus. l-NMMA infusion revealed that FMD following wrist occlusion is mediated exclusively by NO, while dilatation following upper arm occlusion comprises a substantial component not mediated by NO, most probably related to tissue ischaemia around the brachial artery. FMD following wrist occlusion may be a more valid marker of endothelial function than dilatation following upper arm occlusion.

scholarly journals Nifedipine Increases Endothelial Nitric Oxide Bioavailability by Antioxidative Mechanisms

Hypertension ◽  
2001 ◽  
Vol 37 (2) ◽  
pp. 240-245 ◽  
Author(s):  
Reinhard Berkels ◽  
Guido Egink ◽  
Tobias A. Marsen ◽  
Henning Bartels ◽  
Renate Roesen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Nitric Oxide ◽  
Nitric Oxide Bioavailability

Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas

Nitric Oxide ◽  
2007 ◽  
Vol 16 (4) ◽  
pp. 442-447 ◽  
Author(s):  
Ajay Machha ◽  
Francis I. Achike ◽  
Ali Mohd Mustafa ◽  
Mohd Rais Mustafa
Keyword(s):  
Nitric Oxide ◽  
Diabetic Rat ◽  
Nitric Oxide Bioavailability
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