Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas

Nitric Oxide ◽  
2007 ◽  
Vol 16 (4) ◽  
pp. 442-447 ◽  
Author(s):  
Ajay Machha ◽  
Francis I. Achike ◽  
Ali Mohd Mustafa ◽  
Mohd Rais Mustafa
Keyword(s):  
Nitric Oxide ◽  
Diabetic Rat ◽  
Nitric Oxide Bioavailability

Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability

2021 ◽  
Author(s):  
Gustavo H. Oliveira-Paula ◽  
Fernanda Borchers Coeli-Lacchini ◽  
Letícia Perticarrara Ferezin ◽  
Graziele C. Ferreira ◽  
Lucas C. Pinheiro ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Arginase Ii ◽  
Nitric Oxide Bioavailability

scholarly journals Nifedipine Increases Endothelial Nitric Oxide Bioavailability by Antioxidative Mechanisms

Hypertension ◽  
2001 ◽  
Vol 37 (2) ◽  
pp. 240-245 ◽  
Author(s):  
Reinhard Berkels ◽  
Guido Egink ◽  
Tobias A. Marsen ◽  
Henning Bartels ◽  
Renate Roesen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Nitric Oxide ◽  
Nitric Oxide Bioavailability

scholarly journals Sex-specific vascular responses of the rat aorta: effects of moderate term (intermediate stage) streptozotocin-induced diabetes

2016 ◽  
Vol 94 (4) ◽  
pp. 408-415 ◽  
Author(s):  
Xiaoyuan Han ◽  
Sonali Shaligram ◽  
Rui Zhang ◽  
Leigh Anderson ◽  
Roshanak Rahimian
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mrna Expression ◽  
Intermediate Stage ◽  
Diabetic Rats ◽  
Female Rats ◽  
Diabetic Rat ◽  
Male And Female ◽  
Male And Female Rats ◽  
Oxide Synthase

Hyperglycemia affects male and female vascular beds differently. We have previously shown that 1 week after the induction of diabetes with streptozotocin (STZ), male and female rats exhibit differences in aortic endothelial function. To examine this phenomenon further, aortic responses were studied in male and female rats 8 weeks after the induction of diabetes (intermediate stage). Endothelium-dependent vasodilation (EDV) to acetylcholine (ACh) was measured in phenylephrine (PE) pre-contracted rat aortic rings. Concentration response curves to PE were generated before and after L-NAME, a nitric oxide synthase (NOS) inhibitor. Furthermore, mRNA expression of endothelial nitric oxide synthase (eNOS) and NADPH oxidase subunit (Nox1) were determined. At 8 weeks, diabetes impaired EDV to a greater extent in female than male aortae. Furthermore, the responsiveness to PE was significantly enhanced only in female diabetic rats, and basal NO, as indicated by the potentiation of the response to PE after L-NAME, was reduced in female diabetic rat aortae to the same levels as in males. In addition, eNOS mRNA expression was decreased, while the Nox1 expression was significantly enhanced in diabetic female rats. These results suggest that aortic function in female diabetic rats after 8 weeks exhibits a more prominent impairment and that NO may be involved.

scholarly journals Relationship of Cell‐Free Hemoglobin to Impaired Endothelial Nitric Oxide Bioavailability and Perfusion in Severe Falciparum Malaria

2009 ◽  
Vol 200 (10) ◽  
pp. 1522-1529 ◽  
Author(s):  
Tsin W. Yeo ◽  
Daniel A. Lampah ◽  
Emiliana Tjitra ◽  
Retno Gitawati ◽  
Enny Kenangalem ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Falciparum Malaria ◽  
Free Hemoglobin ◽  
Relationship Of ◽  
Endothelial Nitric Oxide ◽  
Severe Falciparum Malaria ◽  
Nitric Oxide Bioavailability
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