scholarly journals Indomethacin markedly blunts cerebral perfusion and reactivity, with little cognitive consequence in healthy young and older adults

2020 ◽  
Author(s):  
L. N. Shoemaker ◽  
L. C. Wilson ◽  
S. J. E. Lucas ◽  
L. Machado ◽  
R. J. Walker ◽  
...  
Keyword(s):  
Older Adults ◽  
Cerebral Perfusion ◽  
Cognitive Consequence

scholarly journals The adverse effects of reduced cerebral perfusion on cognition and brain structure in older adults with cardiovascular disease

2013 ◽  
Vol 3 (6) ◽  
pp. 626-636 ◽  
Author(s):  
Michael L. Alosco ◽  
John Gunstad ◽  
Beth A. Jerskey ◽  
Xiaomeng Xu ◽  
Uraina S. Clark ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Older Adults ◽  
Adverse Effects ◽  
Brain Structure ◽  
Cerebral Perfusion

scholarly journals The Interactive Effects of Cerebral Perfusion and Depression on Cognitive Function in Older Adults With Heart Failure

2013 ◽  
Vol 75 (7) ◽  
pp. 632-639 ◽  
Author(s):  
Michael L. Alosco ◽  
Mary Beth Spitznagel ◽  
Naftali Raz ◽  
Ronald Cohen ◽  
Lawrence H. Sweet ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Cognitive Function ◽  
Cerebral Perfusion ◽  
Interactive Effects

scholarly journals Visit-to-visit Blood Pressure Variability and Regional Cerebral Perfusion Decline in Older Adults

2020 ◽  
Author(s):  
Isabel Sible ◽  
Belinda Yew ◽  
Shubir Dutt ◽  
Katherine J. Bangen ◽  
Yanrong Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Pressure ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Blood Pressure Variability ◽  
Cerebral Perfusion ◽  
Cerebral Spinal Fluid ◽  
Spinal Fluid ◽  
Phosphorylated Tau

Abstract Background: Blood pressure variability has been linked to dementia risk, independent of average blood pressure levels. It has been hypothesized that dysregulated blood pressure may challenge autoregulatory mechanisms and risk cerebral hypoperfusion. The current study examined whether visit-to-visit blood pressure variability over one year is related to concurrent regional cerebral perfusion decline over the same period in older adults.Methods: Sixty-three older adults without history of dementia or stroke underwent repeated blood pressure measurement and arterial spin-labelling magnetic resonance imaging over the same one year period. Fluorodeoxyglucose-positron emission tomography determined cerebral metabolism at baseline. A subset underwent lumbar puncture to detect cerebral spinal fluid amyloid-beta (n=18) and phosphorylated tau (n=21) abnormalities. Visit-to-visit blood pressure variability and change in regional cerebral perfusion were both calculated over 12 months. Multiple linear regression examined relationships between blood pressure variability and change in regional perfusion after controlling for age, sex, average blood pressure, antihypertensive medication use and cerebral metabolism. Exploratory analyses were repeated in participant subsets with abnormal cerebral spinal fluid amyloid-beta and phosphorylated tau.Results: Elevated blood pressure variability was related to perfusion decline in medial orbitofrontal cortex (ß = -.36; p = .008), hippocampus (ß = -.37; p = .005), entorhinal cortex (ß = -.48; p < .001), precuneus (ß = -.31; p = .02), inferior parietal cortex (ß = -.44; p < .001) and inferior temporal cortex (ß = -.46; p < .001). Elevated blood pressure variability was similarly related to perfusion decline in some regions among participant subsets showing abnormal cerebral spinal fluid amyloid-beta and phosphorylated tau.Conclusions: Older adults with elevated visit-to-visit blood pressure variability exhibit concurrent regional cerebral perfusion decline in areas vulnerable to cerebrovascular dysfunction in Alzheimer’s disease, independent of cerebral hypometabolism. Similar findings are observed in exploratory analyses of older adults with Alzheimer’s disease biomarker abnormalities. The study is limited by the small sample size, particularly the subset of participants with Alzheimer’s disease biomarker abnormalities. Findings may have therapeutic implications, given that certain antihypertensive medications have differential effects on variability of blood pressure independent of average levels.

The effect of flavanol rich cocoa on cerebral perfusion in older adults during conscious resting state

Appetite ◽  
2014 ◽  
Vol 83 ◽  
pp. 351
Author(s):  
D. Lamport ◽  
D. Pal ◽  
C. Moutsiana ◽  
D.T. Field ◽  
C.M. Williams ◽  
...  
Keyword(s):  
Older Adults ◽  
Resting State ◽  
Cerebral Perfusion

scholarly journals The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial

2015 ◽  
Vol 232 (17) ◽  
pp. 3227-3234 ◽  
Author(s):  
Daniel J. Lamport ◽  
Deepa Pal ◽  
Christina Moutsiana ◽  
David T. Field ◽  
Claire M. Williams ◽  
...  
Keyword(s):  
Older Adults ◽  
Resting State ◽  
Cerebral Perfusion ◽  
Healthy Older Adults

scholarly journals Mean arterial pressure during cerebral perfusion MRI: An arterial spin‐labeling study in younger and older adults

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Isabel J. Sible ◽  
Belinda Yew ◽  
Shubir Dutt ◽  
Yanrong Li ◽  
Jean K. Ho ◽  
...  
Keyword(s):  
Older Adults ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Arterial Spin Labeling ◽  
Cerebral Perfusion ◽  
Spin Labeling ◽  
Perfusion Mri

scholarly journals Cerebral Perfusion is Associated With White Matter Hyperintensities in Older Adults With Heart Failure

2013 ◽  
Vol 19 (4) ◽  
pp. E29-E34 ◽  
Author(s):  
Michael L. Alosco ◽  
Adam M. Brickman ◽  
Mary Beth Spitznagel ◽  
Sarah L. Garcia ◽  
Atul Narkhede ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
White Matter ◽  
Cerebral Perfusion ◽  
White Matter Hyperintensities

scholarly journals The impact of hypertension on cerebral perfusion and cortical thickness in older adults

2014 ◽  
Vol 8 (8) ◽  
pp. 561-570 ◽  
Author(s):  
Michael L. Alosco ◽  
John Gunstad ◽  
Xiaomeng Xu ◽  
Uraina S. Clark ◽  
Donald R. Labbe ◽  
...  
Keyword(s):  
Older Adults ◽  
Cortical Thickness ◽  
Cerebral Perfusion ◽  
The Impact
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