scholarly journals Cerebral Perfusion is Associated With White Matter Hyperintensities in Older Adults With Heart Failure

2013 ◽  
Vol 19 (4) ◽  
pp. E29-E34 ◽  
Author(s):  
Michael L. Alosco ◽  
Adam M. Brickman ◽  
Mary Beth Spitznagel ◽  
Sarah L. Garcia ◽  
Atul Narkhede ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
White Matter ◽  
Cerebral Perfusion ◽  
White Matter Hyperintensities

scholarly journals A Systematic Review Examining Associations between Cardiovascular Conditions and Driving Outcomes among Older Drivers

Geriatrics ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 27
Author(s):  
Ganesh M. Babulal ◽  
Ramana Kolady ◽  
Sarah H. Stout ◽  
Catherine M. Roe
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Older Adults ◽  
White Matter ◽  
Vascular Dementia ◽  
Older Adult ◽  
White Matter Hyperintensities ◽  
Myocardial Infraction ◽  
Naturalistic Driving ◽  
Driving Outcomes

There is a vast literature on stroke as a cardiovascular disease and driving outcomes, however little is known about other cardiovascular conditions and driving. The purpose of this review is to examine the literature for studies assessing the effect of non-stroke, vascular conditions on daily driving, reported crash risk and driving decline in older adult drivers as captured by naturalistic methodologies. A systematic review of Embase, Ovid and Scopus Plus examined articles on driving and vascular conditions among older adults. A search yielded 443 articles and, following two screenings, no articles remained that focused on non-stroke, vascular conditions and naturalistic driving. As a result, this review examined non-stroke, vascular conditions in nine driving studies of older adults that used road testing, driving simulators and self-report measures. These studies fell into three categories—heart failure, vascular dementia and white matter hyperintensities/leukoaraiosis. The combined findings of the studies suggest that heart failure, vascular dementia and white matter hyperintensities (WMH) negatively impact driving performance and contribute to driving cessation among older adults. Future research should examine cardiovascular risk factors like hypertension, hypercholesterolemia, myocardial infraction or atherosclerosis using naturalistic driving measurement, as well as traditional measures, in order to more fully characterize how these conditions impact older adult driving.

scholarly journals Brain Resilience: The Effect of White Matter Disease on Brain Networks in Cognitively Normal Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 918-918
Author(s):  
Blake Neyland ◽  
Christina Hugenschmidt ◽  
Samuel Lockhart ◽  
Laura Baker ◽  
Suzanne Craft ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Brain Networks ◽  
Network Connectivity ◽  
Anterior Cingulate ◽  
Functional Brain ◽  
Mobility Function ◽  
Functional Brain Networks ◽  
Brain Resilience

Abstract Brain pathologies are increasingly understood to confer mobility risk, but the malleability of functional brain networks may be a mechanism for mobility reserve. In particular, white matter hyperintensities (WMH) are strongly associated with mobility and alter functional network connectivity. To assess the potential role of brain networks as a mechanism of mobility reserve, 116 participants with MRI from the Brain Networks and Mobility Function (B-NET) were categorized into 4 groups based on median splits of SPPB scores and WMH burden: Expected Healthy (EH: low WMH, SPPB>10, N=45), Expected Impaired (EI: high WMH, SPPB10, N=24), Unexpected Impaired (EI: low WMH, SPPB<10, N=10) and Unexpected Unhealthy (UH: low WMH, SPPB<10, N=37). Functional brain networks were calculated using graph theory methods and white matter hyperintensities were quantified with the Lesion Segmentation Toolbox (LST) in SPM12. Somatomotor cortex community structure (SMC-CS) was similar between UH and EH with both having higher consistency than EI and UI. However, UH displayed a unique increase in second-order connections between the motor cortex and the anterior cingulate. It is possible that this increase in connections is a signal of higher reserve or resilience in UH participants and may indicate a mechanism of compensation in regards to mobility function and advanced WMH burden. These data suggest functional brain networks may be a mechanism for mobility resilience in older adults at mobility risk due to WMH burden.

P4-149: Stress and white matter hyperintensities in nondemented older adults

2015 ◽  
Vol 11 (7S_Part_18) ◽  
pp. P836-P836
Author(s):  
Molly E. Zimmerman ◽  
Adam M. Brickman ◽  
Ali Ezzati ◽  
Mindy J. Katz ◽  
Martin J. Sliwinski ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
White Matter Hyperintensities

scholarly journals Independent and interactive effects of blood pressure and cardiac function on brain volume and white matter hyperintensities in heart failure

2013 ◽  
Vol 7 (5) ◽  
pp. 336-343 ◽  
Author(s):  
Michael L. Alosco ◽  
Adam M. Brickman ◽  
Mary Beth Spitznagel ◽  
Erica Y. Griffith ◽  
Atul Narkhede ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
White Matter ◽  
Cardiac Function ◽  
White Matter Hyperintensities ◽  
Brain Volume ◽  
Interactive Effects

scholarly journals Contributors to Poor Mobility in Older Adults: Integrating White Matter Hyperintensities and Conditions Affecting Other Systems

2016 ◽  
pp. glw224 ◽  
Author(s):  
Andrea L. Rosso ◽  
Stephanie A. Studenski ◽  
W. T. Longstreth ◽  
Jennifer S. Brach ◽  
Robert M. Boudreau ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
White Matter Hyperintensities

Clinical correlates of cerebral white matter hyperintensities in cognitively normal older adults

2010 ◽  
Vol 50 (2) ◽  
pp. 127-131 ◽  
Author(s):  
L.R. Williams ◽  
C.E. Hutchinson ◽  
A. Jackson ◽  
M.A. Horan ◽  
M. Jones ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Cerebral White Matter ◽  
Cognitively Normal ◽  
Clinical Correlates
Sign in / Sign up

Export Citation Format

Share Document