scholarly journals Real‐time optical manipulation of cardiac conduction in intact hearts

2018 ◽  
Vol 596 (17) ◽  
pp. 3841-3858 ◽  
Author(s):  
M. Scardigli ◽  
C. Müllenbroich ◽  
E. Margoni ◽  
S. Cannazzaro ◽  
C. Crocini ◽  
...  
Keyword(s):  
Real Time ◽  
Cardiac Conduction ◽  
Optical Manipulation

Real-time optical manipulation of the cardiac conduction pathway (Conference Presentation)

2018 ◽  
Author(s):  
Emilia Margoni ◽  
Samantha Cannazzaro ◽  
Cecilia Ferrantini ◽  
Raffaele Coppini ◽  
Pin Yan ◽  
...  
Keyword(s):  
Real Time ◽  
Cardiac Conduction ◽  
Optical Manipulation ◽  
Conduction Pathway

scholarly journals Real-Time Optical Manipulation of Cardiac Conduction in Intact Hearts

2018 ◽  
Vol 114 (3) ◽  
pp. 166a
Author(s):  
Emilia Margoni ◽  
Samantha Cannazzaro ◽  
Claudia Crocini ◽  
Cecilia Ferrantini ◽  
Raffaele Coppini ◽  
...  
Keyword(s):  
Real Time ◽  
Cardiac Conduction ◽  
Optical Manipulation

Real-time “single beat” non-invasive recording of the cardiac conduction system activity

1982 ◽  
Vol 49 (4) ◽  
pp. 1030
Author(s):  
Tadeusz Palko ◽  
Waldemar J. Wajszczuk ◽  
Thomas J. Bauld ◽  
Melvyn Rubenfire
Keyword(s):  
Real Time ◽  
Conduction System ◽  
Cardiac Conduction ◽  
Cardiac Conduction System ◽  
System Activity ◽  
Non Invasive

scholarly journals Real-time optical manipulation of particles through turbid media

2019 ◽  
Vol 27 (4) ◽  
pp. 4858 ◽  
Author(s):  
Tong Peng ◽  
Runze Li ◽  
Sha An ◽  
Xianghua Yu ◽  
Meiling Zhou ◽  
...  
Keyword(s):  
Real Time ◽  
Turbid Media ◽  
Optical Manipulation

Real-time global Raman imaging and optical manipulation of suspended carbon nanotubes

2006 ◽  
Vol 73 (23) ◽  
Author(s):  
Kate Kaminska ◽  
Jacques Lefebvre ◽  
D. Guy Austing ◽  
Paul Finnie
Keyword(s):  
Carbon Nanotubes ◽  
Real Time ◽  
Raman Imaging ◽  
Optical Manipulation

Abstract 149: Transgenic Overexpression Of HCN4 Induces Right Ventricular Dilated Cardiomyopathy Through Calpain-mediated Apoptosis

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Pessah Yampolsky ◽  
Thomas Fink ◽  
Rüdiger Becker ◽  
Michael Koenen ◽  
Hugo A Katus ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Dilated Cardiomyopathy ◽  
Real Time ◽  
Natriuretic Peptide ◽  
Real Time Pcr ◽  
Molecular Mechanisms ◽  
Glycogen Synthase ◽  
Tissue Transglutaminase ◽  
Cardiac Conduction ◽  
Pcr Analysis

Introduction: Hyperpolarization-activated cation (HCN) channels encode the pacemaker current If that contributes to generation and regulation of sinus rhythm, with HCN4 representing a key component in the cardiac conduction system. Recent studies have identified an increased ventricular expression of HCN4 in patients with hypertrophic cardiomyopathy and heart failure, however the mechanistic involvement of HCN4 in pathogenesis remains unresolved. Methods: We generated transgenic mice that overexpress human HCN4 under the regulation of a cardiac-specific cTNI promoter (HCN4+ mice) to study the contribution of HCN4 overexpression to structural heart disease. Molecular mechanisms were analyzed by quantitative Real-time PCR, western blot and immunohistochemistry. Results: HCN4+ mice were viable and exhibited high expression of HCN4 in both atria and ventricles, with HCN4 protein abundantly targeted to the plasma membrane. Real-time PCR analysis showed a 71% reduction in transcript levels of the endogenous murine HCN4 gene. Morphological evaluation at different developmental stages revealed right ventricular dilation and progressive decrease in wall thickness after one month of age, lacking overt myocardial hypertrophy, significant fibrosis or signs of myocardial inflammation. On the cellular level, the changes were characterized by apoptotic cell loss induced by strong transient expression of mu-calpain Ca2+-sensor and tissue transglutaminase (243% and 397% of wild type, respectively), which resulted in a robust activation of caspase 3. Of note, markers of pathological hypertrophy, that is atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and beta-myosin heavy chain (beta-MHC) remained unchanged. At the same time transcription of the physiological cell growth markers glycogen synthase kinase 3-beta (GSK3B) and mammalian target of rapamycin (mTOR) was elevated. Conclusion: HCN4 overexpression leads to calpain-mediated apoptosis and is associated with right ventricular dilated cardiomyopathy in a transgenic mouse model.

scholarly journals Adaptive Output Tracking of Driven Oscillators

2008 ◽  
Vol 2008 ◽  
pp. 1-14
Author(s):  
Lili Diao ◽  
Martin Guay
Keyword(s):  
Real Time ◽  
Adaptive Learning ◽  
Learning Algorithm ◽  
Tracking Error ◽  
Cardiac Conduction ◽  
Control Technique ◽  
Control Input ◽  
Real Time Control ◽  
Output Tracking ◽  
Time Control

Heart dynamics are usually unknown and require the application of real-time control technique because of the fatal nature of most cardiac arrhythmias. The problem of controlling the heart dynamics in a real-time manner is formulated as an adaptive learning output-tracking problem. For a class of nonlinear dynamic systems with unknown nonlinearities and nonaffine control input, a Lyapunov-based technique is used to develop a control law. An adaptive learning algorithm is exploited that guarantees the stability of the closed-loop system and convergence of the output tracking error to an adjustable neighborhood of the origin. In addition, good approximation of the unknown nonlinearities is also achieved by incorporating a persistent exciting signal in the parameter update law. The effectiveness of the proposed method is demonstrated by an application to a cardiac conduction system modelled by two coupled driven oscillators.

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