scholarly journals Impact of perinatal exposure to sucrose or high fructose corn syrup (HFCS-55) on adiposity and hepatic lipid composition in rat offspring

2017 ◽  
Vol 595 (13) ◽  
pp. 4379-4398 ◽  
Author(s):  
Carla R. Toop ◽  
Beverly S. Muhlhausler ◽  
Kerin O'Dea ◽  
Sheridan Gentili
Keyword(s):  
Lipid Composition ◽  
Perinatal Exposure ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Hepatic Lipid ◽  
Rat Offspring ◽  
High Fructose

The effect of maternal intake of sucrose or high-fructose corn syrup (HFCS)-55 during gestation and lactation on lipogenic gene expression in rat offspring at 3 and 12 weeks of age

2018 ◽  
Vol 9 (5) ◽  
pp. 481-486 ◽  
Author(s):  
H. Kaur ◽  
C. R. Toop ◽  
B. S. Muhlhausler ◽  
S. Gentili
Keyword(s):  
Messenger Rna ◽  
Binding Protein ◽  
Hepatic Metabolism ◽  
Perinatal Exposure ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Hepatic Expression ◽  
Lipogenic Genes ◽  
High Fructose ◽  
Element Binding Protein

AbstractPerinatal exposure to sucrose or high-fructose corn syrup-55 (HFCS-55) in rats has previously been associated with altered hepatic fat content and composition post-weaning, although the effects on hepatic metabolism are unknown. The current study aimed to determine the sex-specific effects of maternal consumption of sucrose or HFCS-55 on the expression of hepatic lipogenic genes in the offspring. Liver samples were collected from offspring of albino Wistar rats provided with ad libitum access to either water (control), 10% sucrose or 10% HFCS-55 solution during pregnancy and lactation at 3 weeks (control n=16, sucrose n=22, HFCS-55 n=16) and 12 weeks (control n=16, sucrose n=10, HFCS-55 n=16) of age. Hepatic expression of the transcription factors such as carbohydrate response element-binding protein, sterol regulatory element-binding protein-1c and downstream genes was determined by quantitative real-time PCR. Sucrose-exposed offspring had higher hepatic SREBP-1c messenger RNA expression compared with control and HFCS-55 groups at both 3 weeks (P=0.01) and 12 weeks (P=0.03) of age. There were no differences in the expression of other hepatic lipogenic genes between groups at either 3 or 12 weeks. Thus, perinatal exposure to sucrose may be more detrimental to offspring hepatic metabolism compared with HFCS-55, independent of sex, and it will be important to evaluate the longer-term effects of perinatal sucrose exposure in future studies.

5-LB: Consuming High-Fructose Corn Syrup or Sucrose-Sweetened Beverages Increases Hepatic Lipid Content and Decreases Insulin Sensitivity in Young Adults

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 5-LB
Author(s):  
DESIREE SIGALA ◽  
BETTINA HIERONIMUS ◽  
CANDICE PRICE ◽  
VIVIEN LEE ◽  
MARINELLE NUNEZ ◽  
...  
Keyword(s):  
Young Adults ◽  
Insulin Sensitivity ◽  
Lipid Content ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Hepatic Lipid ◽  
Sweetened Beverages ◽  
High Fructose ◽  
Hepatic Lipid Content

Fructose and high fructose corn syrup: are they a two-edged sword?

2021 ◽  
pp. 1-23
Author(s):  
Nasim Khorshidian ◽  
Mahdi Shadnoush ◽  
Maryam Zabihzadeh Khajavi ◽  
Sara Sohrabvandi ◽  
Mojtaba Yousefi ◽  
...  
Keyword(s):  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
High Fructose
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