scholarly journals Brown adipose tissue remodelling induced by corticosterone in male Wistar rats

2019 ◽  
Vol 104 (4) ◽  
pp. 514-528 ◽  
Author(s):  
Felippe Mousovich‐Neto ◽  
Marina Souza Matos ◽  
Anna Carolina Rego Costa ◽  
Ricardo Augusto Melo Reis ◽  
Georgia Correa Atella ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Wistar Rats ◽  
Tissue Remodelling ◽  
Brown Adipose ◽  
Male Wistar Rats

Lean in one way, in obesity another: effects of moderate exercise in brown adipose tissue of early overfed male Wistar rats

2021 ◽  
Author(s):  
Douglas Lopes Almeida ◽  
Veridiana Mota Moreira ◽  
Lucas Eduardo Cardoso ◽  
Marcos Divino Ferreira Junior ◽  
Audrei Pavanelo ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Wistar Rats ◽  
Moderate Exercise ◽  
Brown Adipose ◽  
Male Wistar Rats

Adaptive changes in brown adipose tissue in Wistar rats, Zucker lean and obese rats

2001 ◽  
Vol 26 (4-5) ◽  
pp. 473-477
Author(s):  
Kazuko Hori ◽  
Tohru Ishigaki ◽  
Katsuhiro Koyama ◽  
Mitsuharu Kaya ◽  
Junzo Tsujita ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Wistar Rats ◽  
Adaptive Changes ◽  
Brown Adipose ◽  
Obese Rats

scholarly journals Ageing is associated with brown adipose tissue remodelling and loss of white fat browning in female C57BL/6 mice

2017 ◽  
Vol 98 (2) ◽  
pp. 100-108 ◽  
Author(s):  
Leidyanne Ferreira Gonçalves ◽  
Thaissa Queiroz Machado ◽  
Camila Castro-Pinheiro ◽  
Nathalia Guimaraes de Souza ◽  
Karen Jesus Oliveira ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Tissue Remodelling ◽  
Brown Adipose ◽  
White Fat

Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats

2001 ◽  
Vol 280 (6) ◽  
pp. E867-E876 ◽  
Author(s):  
Keiko Arai ◽  
Kyongsong Kim ◽  
Katsumi Kaneko ◽  
Mitsue Iketani ◽  
Asuka Otagiri ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Mrna Expression ◽  
Wistar Rats ◽  
Uncoupling Protein ◽  
Plasma Concentrations ◽  
Uncoupling Protein 1 ◽  
Adipose Tissues ◽  
Brown Adipose ◽  
Male Wistar Rats ◽  
Infusion Period

We attempted to clarify whether leptin and uncoupling protein 1 (UCP1) are involved in the action of nicotine on the energy balance. Male Wistar rats were infused subcutaneously with nicotine (12 mg · kg−1 · day−1) for 4 or 14 days. At the end of the 4-day period, the plasma concentrations of leptin of the nicotine-treated and pair-fed rats were lower than those of the freely fed rats, although the levels of leptin mRNA expression in various white adipose tissues did not differ among the three groups. At the end of the 14-day nicotine infusion period, plasma concentrations of leptin were higher, and leptin mRNA expression in the omentum and epididymal and retroperitoneal adipose tissues was stronger in the nicotine-treated rats than in the pair-fed and freely fed rats. UCP1 mRNA expression in the brown adipose tissue of nicotine-treated was stronger than that of the pair-fed rats. These results suggest that continuous nicotine infusion differentially affects the synthesis and secretion of leptin according to the duration of infusion and stimulates UCP1 mRNA expression, probably in a manner independent of leptin.

scholarly journals Stimulation of the hypothalamic arcuate nucleus increases brown adipose tissue nerve activity via hypothalamic paraventricular and dorsomedial nuclei

2016 ◽  
Vol 311 (2) ◽  
pp. H433-H444 ◽  
Author(s):  
Vineet C. Chitravanshi ◽  
Kazumi Kawabe ◽  
Hreday N. Sapru
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Arcuate Nucleus ◽  
Glutamate Transporter ◽  
Nerve Activity ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose ◽  
Hypothalamic Arcuate Nucleus ◽  
Male Wistar Rats ◽  
Stimulation Of

Hypothalamic arcuate nucleus (ARCN) stimulation elicited increases in sympathetic nerve activity (IBATSNA) and temperature (TBAT) of interscapular brown adipose tissue (IBAT). The role of hypothalamic dorsomedial (DMN) and paraventricular (PVN) nuclei in mediating these responses was studied in urethane-anesthetized, artificially ventilated, male Wistar rats. In different groups of rats, inhibition of neurons in the DMN and PVN by microinjections of muscimol attenuated the increases in IBATSNA and TBAT elicited by microinjections of N-methyl-d-aspartic acid into the ipsilateral ARCN. In other groups of rats, blockade of ionotropic glutamate receptors by combined microinjections of D(-)-2-amino-7-phosphono-heptanoic acid (D-AP7) and NBQX into the DMN and PVN attenuated increases in IBATSNA and TBAT elicited by ARCN stimulation. Blockade of melanocortin 3/4 receptors in the DMN and PVN in other groups of rats resulted in attenuation of increases in IBATSNA and TBAT elicited by ipsilateral ARCN stimulation. Microinjections of Fluoro-Gold into the DMN resulted in retrograde labeling of cells in the ipsilateral ARCN, and some of these cells contained proopiomelanocortin (POMC), α-melanocyte-stimulating hormone (α-MSH), or vesicular glutamate transporter-3. Since similar projections from ARCN to the PVN have been reported by us and others, these results indicate that neurons containing POMC, α-MSH, and glutamate project from the ARCN to the DMN and PVN. Stimulation of ARCN results in the release of α-MSH and glutamate in the DMN and PVN which, in turn, cause increases in IBATSNA and TBAT.

scholarly journals DUODENAL-JEJUNAL BYPASS REDUCES LIPID ACCUMULATION IN THE BROWN ADIPOSE TISSUE OF HYPOTHALAMIC OBESE RATS

2020 ◽  
Vol 33 (1) ◽  
Author(s):  
Vanessa Marieli CEGLAREK ◽  
Zoé Maria GUARESCHI ◽  
Gabriela MOREIRA-SOARES ◽  
Rafaela Cristiane ECKER-PASSARELLO ◽  
Sandra Lucinei BALBO ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Lipid Accumulation ◽  
Monosodium Glutamate ◽  
Sham Operation ◽  
Lipid Deposition ◽  
Brown Adipose ◽  
Obese Rats ◽  
Male Wistar Rats ◽  
Jejunal Bypass

ABSTRACT Background: Thermogenic activity in the brown adipose tissue (BAT) of obese individuals is reduced, and this condition may be modified by bariatric surgery (BS). Aim: To characterize fat deposition in BAT from hypothalamic obese (HyO) rats submitted to duodenal-jejunal-bypass (DJB) surgery. Methods: For induction of hypothalamic obesity, newborn male Wistar rats were treated with subcutaneous injections of monosodium glutamate (MSG). The control (CTL) group received saline solution. At 90 days, the HyO rats were submitted to DJB or sham operation, generating the HyO-DJB and HyO-SHAM groups. At 270 days, the rats were euthanized, and the BAT was weighed and submitted to histological analysis. Results: Compared to BAT from CTL animals, the BAT from HyO-SHAM rats displayed increased weight, hypertrophy with greater lipid accumulation and a reduction in nucleus number. DJB effectively increased nucleus number and normalized lipid deposition in the BAT of HyO-SHAM rats, similar to that observed in CTL animals. Conclusion: DJB surgery avoided excessive lipid deposition in the BAT of hypothalamic obese rats, suggesting that this procedure could reactivate thermogenesis in BAT, and contribute to increase energy expenditure.

Responses of brown adipose tissue activity to unloading in rats

1995 ◽  
Vol 78 (2) ◽  
pp. 384-387 ◽  
Author(s):  
H. Yamashita ◽  
Y. Ohira ◽  
T. Wakatsuki ◽  
M. Yamamoto ◽  
T. Kizaki ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Uncoupling Protein ◽  
Mitochondrial Fraction ◽  
Hindlimb Suspension ◽  
Chemical Components ◽  
Brown Adipose ◽  
Male Wistar Rats ◽  
Brown Adipose Tissue Activity ◽  
Thermogenic Capacity

To study the responses of thermogenic activity in brown adipose tissue (BAT) to unloading, male Wistar rats were hindlimb suspended for 10 days. Compared with control rats, a significant increase in the BAT-to-body mass ratio and considerable differences in chemical components in BAT were observed in the hindlimb-suspended rats. These findings indicate a marked increase in the thermogenic capacity in BAT of the experimental group. Likewise, the thermogenic activity (which was assessed by guanosine 5′-diphosphate binding to BAT mitochondria) was markedly greater in the mitochondria recovered from BAT of the hindlimb-suspended rats than in those from the control rats (1,610 +/- 450 vs. 202 +/- 132 pmol recovered). Moreover, the uncoupling protein content in the BAT mitochondrial fraction of the hindlimb-suspended rats was significantly higher (1.6-fold) than that in the control rats. As was expected, the uncoupling protein mRNA expression was greater in hindlimb-suspended rats than in control animals. These results suggest that chronic hindlimb suspension leads to an increase in both the thermogenic capacity and the activity in BAT of rats.

scholarly journals Vascular Effects of GI262570X (PPAR-γ agonist) in the Brown Adipose Tissue of Han Wistar Rats: A Review of 1-month, 13-week, 27-week and 2-year Oral Toxicity Studies

2002 ◽  
Vol 30 (4) ◽  
pp. 420-426 ◽  
Author(s):  
Chandikumar S. Elangbam ◽  
Thomas A. Brodie ◽  
H. Roger Brown ◽  
James B. Nold ◽  
Timothy J. Raczniak ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Wistar Rats ◽  
Oral Toxicity ◽  
Vascular Effects ◽  
Toxicity Studies ◽  
Ppar Γ ◽  
Brown Adipose
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