LncRNA MIR503HG promotes hypertrophic scar progression via miR ‐143‐3p‐mediated Smad3 expression

2021 ◽  
Author(s):  
Jun Wei ◽  
Zhiyong Wang ◽  
Chaoyi Zhong ◽  
Huarong Ding ◽  
Xiqiao Wang ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
Smad3 Expression

miR-145-5p attenuates hypertrophic scar via reducing Smad2/Smad3 expression

2020 ◽  
Vol 521 (4) ◽  
pp. 1042-1048 ◽  
Author(s):  
Weichang Shen ◽  
Yingqian Wang ◽  
Dewei Wang ◽  
Hong Zhou ◽  
Huafeng Zhang ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
Smad3 Expression

Fibroblasts During Hypertrophic Scar Formation and Resolution

1973 ◽  
Vol 31 ◽  
pp. 428-429
Author(s):  
C. W. Kischer
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Cell Proliferation ◽  
Fine Structure ◽  
Metabolic Activity ◽  
Hypertrophic Scar ◽  
Normal Skin ◽  
Ground Substance ◽  
Hypertrophic Scars ◽  
Scanning Electron

The morphology of the fibroblasts changes markedly as the healing period from burn wounds progresses, through development of the hypertrophic scar, to resolution of the scar by a self-limiting process of maturation or therapeutic resolution. In addition, hypertrophic scars contain an increased cell proliferation largely made up of fibroblasts. This tremendous population of fibroblasts seems congruous with the abundance of collagen and ground substance. The fine structure of these cells should reflect some aspects of the metabolic activity necessary for production of the scar, and might presage the stage of maturation.A comparison of the fine structure of the fibroblasts from normal skin, different scar types, and granulation tissue has been made by transmission (TEM) and scanning electron microscopy (SEM).

Dupuytren's Contracture and Microvessels

1981 ◽  
Vol 39 ◽  
pp. 470-471
Author(s):  
C. W. Klscher ◽  
D. Speer
Keyword(s):  
Hypertrophic Scar ◽  
Active Form ◽  
Scar Tissue ◽  
Vascular Supply ◽  
Fiber Bundles ◽  
Dupuytren’S Contracture ◽  
Palmar Fascia ◽  
Immune Disease ◽  
Dupuytren's Contracture ◽  
Longitudinal Fiber

Dupuytren's Contracture is a nodular proliferation of the longitudinal fiber bundles of palmar fascia with its attendant contraction. The factors attributed to its etiology have included trauma, diabetes, alcoholism, arthritis, and auto-immune disease. The tissue has been observed by electron microscopy and found to contain myofibroblasts.Dupuytren's Contracture constitutes a scar, and as such, excessive collagen can be observed, along with an active form of fibroblast.Previous studies of the hypertrophic scar have led us to propose that integral in the initiation and sustenance of scar tissue is a profusion of microvascular regeneration, much of which becomes and remains occluded producing a hypoxia which stimulates fibroblast synthesis. Thus, when considering a study of Dupuytren's Contracture, we predicted finding occluded microvessels at or near the fascial scarring focus.Three cases of Dupuytren's Contracture yielded similar specimens, which were fixed in Karnovskys fluid for 2 to 20 days. Upon removal of the contracture bands care was taken to include the contiguous fatty and areolar tissue which contain the vascular supply and to identify the junctional area between old and new fascia.

Pressure Techniques For The Prevention Of Hypertrophic Scar

1992 ◽  
Vol 19 (3) ◽  
pp. 733-743 ◽  
Author(s):  
Judith A. Carr-Collins
Keyword(s):  
Hypertrophic Scar

Hypertrophic Scar with Chronic Pain after Acute Herpes Zoster -A case report-

2005 ◽  
Vol 18 (2) ◽  
pp. 229 ◽  
Author(s):  
Jong Cheol Choi ◽  
Hong Beom Bae ◽  
Sung Tae Jeong ◽  
Seok Jai Kim ◽  
Seong Wook Jeong ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Case Report ◽  
Herpes Zoster ◽  
Hypertrophic Scar ◽  
Acute Herpes Zoster

scholarly journals The effect of TGFβRI inhibition on fibroblast heterogeneity in hypertrophic scar 2D in vitro models

Burns ◽  
2021 ◽  
Author(s):  
Rajiv S. Raktoe ◽  
Marion H. Rietveld ◽  
Jacoba J. Out-Luiting ◽  
Marianna Kruithof-de Julio ◽  
Paul P.M. van Zuijlen ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
In Vitro Models ◽  
Fibroblast Heterogeneity

34 Rete Ridges are Decreased in Dyschromic Burn Hypertrophic Scar: A Histological Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S27-S27
Author(s):  
Bonnie C Carney ◽  
Taryn E Travis ◽  
Romina Deldar ◽  
Lauren T Moffatt ◽  
Laura S Johnson ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Hypertrophic Scar ◽  
Burn Injury ◽  
Histological Study ◽  
Normal Skin ◽  
Weak Correlation ◽  
Rete Ridge ◽  
Skin Physiology ◽  
Predominantly Female ◽  
Injured Skin

Abstract Introduction Dyschromic hypertrophic scar (HTS) with areas of hyper- and hypo-pigmentation is a common sequelae of burn injury. The mechanism behind the development of dyschromia has not been elucidated. In this study, we provide a histological analysis of these scars with a focus on rete ridge presence. Rete ridges occur in epithelial tissues such as oral mucosa and skin and can be described as undulating “pegs” that are interdigitated with dermal papillae. Rete ridges enhance adhesion of the epidermis to the dermis. We hypothesize that rete ridge presence is important for normal skin physiology, and their absence or presence may hold mechanistic significance in post-burn HTS dyschromia. Methods Subjects with post-burn dyschromic HTS were consented and enrolled (n=27). Punch biopsies of hyper-, hypo-, and normally pigmented scar and skin were collected and stored in formalin. Biopsies were paraffin embedded, sectioned, stained with H&E, and imaged. The number of rete ridges were investigated by calculating a rete ridge ratio from the length of the basement membrane and the length of the epidermis. Results The patient population was predominantly female (55.5%), black (70.4%), and had Fitzpatrick skin Type V (51.9%). The injuries were primarily as a result of flame (37%) and scald (33.3%) and resulted in a median TBSA burn of 7%. The median age of the scar at the time of sample acquisition was 12.2 months. The rete ridge ratio of normally pigmented, un-injured skin was above 1 (1.31 ± 0.04), indicating that normal skin’s basement membrane is longer than its epidermal length due to the presence of rete ridges. HTSs resulting from burn wounds that healed without split thickness autografts were first investigated. The number of rete ridges was higher in normal skin compared to HTS that was either hypo- or hyperpigmented (1.31 ± 0.04 vs. 1.13 ± 0.05 and 1.14 ± 0.04 vs, p< 0.05). This difference was similar despite pigmentation phenotype. When hyper-pigmented scars resulting from wounds that were treated with split thickness autografts (Hyper(+)) were investigated, rete ridge number was significantly higher than in Hyper(-) (1.89 ± 0.23, p< 0.01). Patient age showed a weak correlation (R=-0.33) with rete ridge ratio where older patients had lower rete ridge ratios in normal, un-injured skin. Hyper(+) showed a weak correlation between rete ridge ratio and age of scar (R=-0.38). Conclusions Post-burn HTS that is dyschromic has fewer rete ridges than normal skin. This finding may explain the decreased epidermal barrier function that is associated with HTS.

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