Effectiveness and safety of human amnion/chorion membrane therapy for diabetic foot ulcers: An updated meta‐analysis of randomized clinical trials

2020 ◽  
Vol 28 (6) ◽  
pp. 739-750
Author(s):  
Wentao Huang ◽  
Yongsong Chen ◽  
Nasui Wang ◽  
Guoshu Yin ◽  
Chiju Wei ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Diabetic Foot ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Human Amnion

scholarly journals The Efficacy and Safety of Acellular Matrix Therapy for Diabetic Foot Ulcers: A Meta-Analysis of Randomized Clinical Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Wentao Huang ◽  
Yongsong Chen ◽  
Nasui Wang ◽  
Guoshu Yin ◽  
Chiju Wei ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Adverse Events ◽  
Healing Rate ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Complete Healing ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Efficacy And Safety ◽  
Acellular Matrix

Background. Acellular matrix (AM) therapy has shown promise in the treatment of diabetic foot ulcers (DFUs) in several studies. The clinical effects of AM therapy were not well established. Therefore, we conducted a meta-analysis of randomized clinical trials (RCTs) to examine the efficacy and safety of AM therapy for patients with DFUs. Methods. A literature search of 5 databases was performed to identify RCTs comparing AM therapy to standard therapy (ST) in patients with DFUs. The primary outcome was the complete healing rate and the secondary outcomes mainly included time to complete healing and adverse events. Results. Nine RCTs involving 897 patients were included. Compared with ST group, patients allocated to AM group had a higher complete healing rate both at 12 weeks (risk ratio RR=1.73, 95% confidence interval (CI): 1.31 to 2.30) and 16 weeks (RR=1.56, 95% CI: 1.28 to 1.91), a shorter time to complete healing (mean difference MD=−2.41; 95% CI: -3.49 to -1.32), and fewer adverse events (RR=0.64, 95% CI: 0.44 to 0.93). Conclusion. The present study suggests that AM therapy as an adjuvant treatment could further promote the healing of full-thickness, noninfected, and nonischemia DFUs. AM therapy also has a safety profile. More large well-designed randomized clinical trials with long follow-up duration are needed to further explore the efficacy and safety of AM therapy for DFUs.

scholarly journals Human Amnion Chorion Membrane Allografts in the Treatment of Chronic Diabetic Foot Ulcers: A Literature Review

2021 ◽  
Vol 34 (4) ◽  
pp. 1-7
Author(s):  
Alisha Oropallo ◽  
Ashley Goodwin ◽  
MaKenzie Morrissey ◽  
Christina Del Pin ◽  
Amit Rao
Keyword(s):  
Literature Review ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Human Amnion

scholarly journals A systematic review and meta-analysis of débridement methods for chronic diabetic foot ulcers

2016 ◽  
Vol 63 (2) ◽  
pp. 37S-45S.e2 ◽  
Author(s):  
Tarig Elraiyah ◽  
Juan Pablo Domecq ◽  
Gabriela Prutsky ◽  
Apostolos Tsapas ◽  
Mohammed Nabhan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Diabetic Foot ◽  
Meta Analysis ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

scholarly journals Imaging for detection of osteomyelitis in people with diabetic foot ulcers: A systematic review and meta-analysis

2020 ◽  
Vol 131 ◽  
pp. 109215
Author(s):  
Alexis Llewellyn ◽  
Jeannette Kraft ◽  
Colin Holton ◽  
Melissa Harden ◽  
Mark Simmonds
Keyword(s):  
Systematic Review ◽  
Diabetic Foot ◽  
Meta Analysis ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

scholarly journals Low Level Laser Therapy for the Treatment of Diabetic Foot Ulcers: A Critical Survey

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Kathrin H. Beckmann ◽  
Gesa Meyer-Hamme ◽  
Sven Schröder
Keyword(s):  
Clinical Trials ◽  
Laser Therapy ◽  
Diabetic Foot ◽  
Animal Studies ◽  
Wound Care ◽  
Low Level Laser Therapy ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Low Level Laser ◽  
Level Laser

Diabetic foot ulcers as one of the most common complications of diabetes mellitus are defined as nonhealing or long-lasting chronic skin ulcers in diabetic patients. Multidisciplinary care for the diabetic foot is common, but treatment results are often unsatisfactory. Low level laser therapy (LLLT) on wound areas as well as on acupuncture points, as a noninvasive, pain-free method with minor side effects, has been considered as a possible treatment option for the diabetic foot syndrome. A systematic literature review identified 1764 articles on this topic. Finally, we adopted 22 eligible references; 8 of them were cell studies, 6 were animal studies, and 8 were clinical trials. Cell studies and animal studies gave evidence of cellular migration, viability, and proliferation of fibroblast cells, quicker reepithelization and reformed connective tissue, enhancement of microcirculation, and anti-inflammatory effects by inhibition of prostaglandine, interleukin, and cytokine as well as direct antibacterial effects by induction of reactive oxygen species (ROS). The transferral of these data into clinical medicine is under debate. The majority of clinical studies show a potential benefit of LLLT in wound healing of diabetic ulcers. But there are a lot of aspects in these studies limiting final evidence about the actual output of this kind of treatment method. In summary, all studies give enough evidence to continue research on laser therapy for diabetic ulcers, but clinical trials using human models do not provide sufficient evidence to establish the usefulness of LLLT as an effective tool in wound care regimes at present. Further well designed research trials are required to determine the true value of LLLT in routine wound care.

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