Comparison of venous hemoglobin saturation measurements obtained by in vivo oximetry and calculated from blood gas analysis in critically ill dogs

2021 ◽  
Author(s):  
Rebecca A. L. Walton ◽  
Bernie Hansen
Keyword(s):  
Critically Ill ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas ◽  
Hemoglobin Saturation

Therapeutic effect of in vivo transfection of transcription factor decoy to NF-κB on septic lung in mice

2004 ◽  
Vol 287 (6) ◽  
pp. L1248-L1255 ◽  
Author(s):  
Naoyuki Matsuda ◽  
Yuichi Hattori ◽  
Yoshika Takahashi ◽  
Jun Nishihira ◽  
Subrina Jesmin ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Histidine Decarboxylase ◽  
Endotoxic Shock ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas ◽  
Transcription Factor Decoy ◽  
Gene And Protein Expression ◽  
Lung Vascular Permeability

Nuclear factor-κB (NF-κB) plays a key role in regulating expression of several genes involved in the pathophysiology of endotoxic shock. We investigated whether in vivo introduction of synthetic double-stranded DNA with high affinity for the NF-κB binding site could block expression of genes mediating pulmonary vascular permeation and thereby provide effective therapy for septic lung failure. Endotoxic shock was induced by an intravenous injection of 10 mg/kg Escherichia coli endotoxin in mice. We introduced NF-κB decoy oligodeoxynucleotide (ODN) in vivo 1 h after endotoxic shock by using a gene transfer kit. At 10 h, blood samples were collected for measurement of histamine and for blood-gas analysis. Gene and protein expression levels of target molecules were determined by means of Northern and Western blot analyses, respectively. The transpulmonary flux of 125I-labeled albumin was used as an index of lung vascular permeability. Administration of endotoxin caused marked increases in plasma histamine and gene and protein expressions of histidine decarboxylase, histamine H1 receptors, and inducible nitric oxide synthase in lung tissues. Elevated lung vascular permeability was also found. Blood-gas analysis showed concurrent decreases in arterial Po2, Pco2, and pH. All of these events induced by endotoxin were significantly inhibited by transfection of NF-κB decoy ODN but not by its mutated (scrambled) form (used as a control). Our results indicate for the first time the potential usefulness of NF-κB decoy ODN for gene therapy of endotoxic shock.

CORRELATION OF VENOUS BLOOD GAS AND PULSE OXIMETRY WITH ARTERIAL BLOOD GAS IN CRITICALLY ILL PATIENTS

2021 ◽  
pp. 1-3
Author(s):  
Sritam Mohanty ◽  
Rangaraj Setlur ◽  
Jyoti Kumar Sinha
Keyword(s):  
Pulse Oximetry ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Venous Blood ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas ◽  
Gold Standard Method ◽  
Arterial Blood Gas ◽  
Arterial Blood

Introduction: Arterial blood gas (ABG) analysis is the gold standard method and frequently performed intervention to evaluate acid-base status along with adequacy of ventilation and oxygenation among patients with predominantly critical / acute diseases. Aims And Objectives: The aim of this study is to evaluate the correlation of VBG analysis and pulse oximetry (SpO2) with ABG analysis in critically ill patients. Materials And Methods:Intensive Care Unit (ICU), Command Hospital (Eastern Command), Kolkata, Adult patients requiring arterial blood gas analysis, JAN 2018 –JUNE 2019, 100 critically ill patients and Age – 18yrs and older, Sex – Either sex. Conclusion: In this study population of critically ill patients, pH and pCO2 on VBG analysis correlated with pH and pCO2 on ABG analysis. The SpO2 correlated well with pO2 on ABG analysis

Iatrogenic Anaemia in the Critically Ill: A Survey of the Frequency of Blood Testing in a Teaching Hospital Intensive Care Unit

2009 ◽  
Vol 10 (4) ◽  
pp. 279-281 ◽  
Author(s):  
Tim Astles
Keyword(s):  
Intensive Care ◽  
Critically Ill ◽  
Teaching Hospital ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas ◽  
Arterial Blood Gas ◽  
Day Range ◽  
Arterial Blood ◽  
Blood Gas Analyses

Anaemia in the critically ill remains a contentious issue. Despite adoption of lower haemoglobin levels as transfusion triggers, many patients on intensive care units (ICUs) still require blood transfusions during their illness. One factor that contributes to the critically ill becoming anaemic is regular phlebotomy. Over a two week period, all blood tests performed on patients in a busy, teaching hospital ICU were surveyed to allow calculation of the total volume of blood that had been taken. On average, 52.4 mL of blood was taken per patient per day, and 366.8 mL per patient per week. The most frequently performed tests were arterial blood gas analyses, performed on average 5.8 times per patient per day (range 0–21 times per day). Arterial blood gas analysis alone accounted for taking of 29 mL of blood per patient per day, ie 203 mL per patient per week. Several methods for reducing the amount of blood taken from ICU patients have been identified and discussed. By implementing some of these simple changes in our institution, it would be possible to reduce the volume of blood taken by 43%.

scholarly journals Concordance between point-of-care blood gas analysis and laboratory autoanalyzer in measurement of hemoglobin and electrolytes in critically ill patients

2018 ◽  
Vol 32 (6) ◽  
pp. e22425 ◽  
Author(s):  
Shivesh Prakash ◽  
Shailesh Bihari ◽  
Zhan Y. Lim ◽  
Santosh Verghese ◽  
Hemant Kulkarni ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Point Of Care ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas

In vivo arterial blood gas analysis

1980 ◽  
Vol 8 (7) ◽  
pp. 414-417 ◽  
Author(s):  
JAMES R. HALL ◽  
THOMAS J. POULTON ◽  
JOHN B. DOWNS ◽  
IRVIN F. HAWKINS ◽  
CAROLE A. CRAWFORD
Keyword(s):  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Arterial Blood Gas Analysis

Monitoring of renal venous Po2 and kidney oxygen consumption in rats by a near-infrared phosphorescence lifetime technique

2008 ◽  
Vol 294 (3) ◽  
pp. F676-F681 ◽  
Author(s):  
Egbert G. Mik ◽  
Tanja Johannes ◽  
Can Ince
Keyword(s):  
Oxygen Consumption ◽  
Near Infrared ◽  
Venous Blood ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Water Soluble ◽  
Blood Gas ◽  
Phosphorescence Lifetime ◽  
Blood Samples ◽  
Hemoglobin Saturation

Renal oxygen consumption (V̇o2,ren) is an important parameter that has been shown to be influenced by various pathophysiological circumstances. V̇o2,ren has to be repeatedly measured during an experiment to gain insight in the dynamics of (dys)regulation of oxygen metabolism. In small animals, the classical approach of blood gas analysis of arterial and venous blood samples is only limitedly applicable due to fragile vessels and a low circulating blood volume. We present a phosphorescence lifetime technique that allows near-continuous measurement of renal venous Po2 (vPo2) and V̇o2,ren in rats. The technique does not rely on penetration of the blood vessel, but uses a small reflection probe. This probe is placed in close proximity to the renal vein for detection of the oxygen-dependent phosphorescence of the injected water-soluble near-infrared phosphor Oxyphor G2. The technique was calibrated in vitro and the calibration constants were validated in vivo in anesthetized and mechanically ventilated male Wistar rats. The hemoglobin saturation curve and its pH dependency were determined for calculation of renal venous oxygen content. The phosphorescence technique was in good agreement with blood gas analysis of renal venous blood samples, for both Po2 and hemoglobin saturation. To demonstrate its feasibility in practice, the technique was used in four rats during endotoxin infusion (10 mg·kg−1·h−1 during 1 h). Renal vPo2 reduced by 40% upon reduction in oxygen delivery to 30% of baseline, but V̇o2 remained unchanged. This study documents the feasibility of near-continuous, nondestructive measurement of renal vPo2 and V̇o2 by oxygen-dependent quenching of phosphorescence.

scholarly journals Peripheral venous blood gas analysis: An alternative to arterial blood gas analysis for resuscitation and monitoring of critically ill patients.

2016 ◽  
Vol 4 (2) ◽  
pp. 92-95
Author(s):  
ASM Areef Ahsan ◽  
Mohammad Omar Faruq ◽  
Kaniz Fatema ◽  
Fatema Ahmed ◽  
Debasish Kumar Saha ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Base Excess ◽  
Blood Gases ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas ◽  
Acid Base ◽  
Venous Sample ◽  
Acid Base Status

Objective: This study was aimed to compare between arterial and peripheral venous samples for blood gases and acid base status in critically ill patients and to evaluate if venous sample is a better alternative for initial assessment and resuscitation.Methods: This prospective study was conducted on 50 patients of more than 18 years of age in the department of Critical Care Medicine, BIRDEM General Hospital. Arterial and peripheral venous samples were taken within five minutes of each other and analyzed immediately for blood gases and acid base status. Mean difference and Pearson's product moment correlation coefficient was used to compare the result.Results: Mean difference and correlation coefficient between arterial and peripheral venous sample for pH, bicarbonate, base excess, PaCO2 and TCO2 value showed high correlation (r > 0.9). Comparison of electrolyte and hematocrit between arterial and peripheral venous sample also showed high correlation (r > 0.9).Conclusion: Peripheral venous gas analysis for pH, bicarbonate, base excess, PCO2 and Electrolytes (Na+, K+) show good correlation with the respective arterial values. This result suggests that venous estimations can be an acceptable alternative to arterial measurements for managing critically ill patients.Bangladesh Crit Care J September 2016; 4 (2): 92-95

scholarly journals Short-Term Outcome and Characteristics of Critical Care for Non-Trauma Patients in the Emergency Department

2020 ◽  
Author(s):  
Jessika Stefanie Kreß ◽  
Marc Rüppel ◽  
Hendrik Haake ◽  
Jürgen vom Dahl ◽  
Sebastian Bergrath
Keyword(s):  
Critical Care ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Blood Gas Analysis ◽  
Patient Characteristics ◽  
Gas Analysis ◽  
Trauma Patients ◽  
Blood Gas ◽  
Short Term ◽  
Resuscitation Room

Abstract Background: Emergency medical care for critically ill patients varies between different emergency departments (ED) and health care systems, while resuscitation of trauma patients is always performed within the ED. In many ED critically ill patients are treated and stabilized while in many German ED they are transferred to intensive care units (ICU) without performing of critical care measures in the ED. Against this background we conducted this retrospective analysis of prospectively collected critically ill patients treated with an ED critical care concept in a 754-bed teaching hospital. Methods: The collective of prospectively collected critically ill patients (October 1st 2018 to March 31st 2019) was analysed after ethical approval. Patient characteristics, performed critical care measures, short-term outcomes and the comparison of admission characteristics between survivors and non-survivors were evaluated. Additionally the accordance of ED diagnoses and discharge diagnoses were analysed.Results: Overall 243/19,854 patients (1.22%) were treated within the resuscitation room. After exclusion of trauma patients, 193 critically ill patients were included. Overall mortality was 29% (n=56), 24-hour mortality was 13% (n=25). Patient characteristics (vital signs, blood gas analysis) differed significantly between survivors and non-survivors except for respiratory rate and pain scale. Conducted critical care measures (number ± standard deviation; e.g. endotracheal intubation, arterial-line): 4.06±1.73 (survivors) and 4.70±2.0 (non-survivors) p=0.0453. The length of ED stay was 148.2±202.7 min. Admission diagnoses matched with hospital discharge diagnoses in 73.7%.Conclusions: Critical care stabilisation of non-trauma patients was feasible in routine care. The observed mortality was high and non-survivors showed significantly more impaired vital parameters and blood gas analysis parameters. Vital parameters together with blood gas analysis enable ED risk stratification of CIP. Although a first diagnostic workup was performed within the ED, admission and discharge diagnoses matched only in 73.7%. However, stabilisation and diagnostic workup of CIP enables optimal allocation to specialized ICUs. Future (randomised) trials have to evaluate of resuscitation room stabilisation for non-trauma patients is beneficial in contrast to direct ICU admission. Trial registration: The study was registered retrospectively in the Clinical Trials Centre of the RWTH Aachen University (Germany), registration number CTC-A 20-131.

Non-Polarographic Blood Gas Analysis II. In Vivo Evaluation of Gas Chromatograph System

1977 ◽  
Vol 5 (3) ◽  
pp. 293-302 ◽  
Author(s):  
J. C. Behrens-Tepper ◽  
T. A. Massaro ◽  
S. J. Updike ◽  
J. D. Folts
Keyword(s):  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas ◽  
Gas Chromatograph ◽  
In Vivo Evaluation

Lactate, pH, and blood gas analysis in critically ill patients

1995 ◽  
Vol 39 ◽  
pp. 267-271 ◽  
Author(s):  
T. WALDAU ◽  
V. H. LARSEN ◽  
J. BONDE ◽  
N. FOGH-ANDERSEN
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas
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