scholarly journals Evaluation of the effects of hydroxyethyl starch (130/0.4) administration as a constant rate infusion on plasma colloid osmotic pressure in hypoabluminemic dogs

2020 ◽  
Vol 30 (5) ◽  
pp. 550-557
Author(s):  
Antonio Borrelli ◽  
Cristiana Maurella ◽  
Ilaria Lippi ◽  
Francesco Ingravalle ◽  
Angelica Botto ◽  
...  
Keyword(s):  
Osmotic Pressure ◽  
Hydroxyethyl Starch ◽  
Colloid Osmotic Pressure ◽  
Constant Rate Infusion ◽  
Constant Rate ◽  
Rate Infusion

scholarly journals Thromboelastometric assessment of hemostasis following hydroxyethyl starch (130/0.4) administration as a constant rate infusion in hypoalbuminemic dogs

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Angelica Botto ◽  
Barbara Bruno ◽  
Cristiana Maurella ◽  
Fulvio Riondato ◽  
Alberto Tarducci ◽  
...  
Keyword(s):  
Hydroxyethyl Starch ◽  
Constant Rate Infusion ◽  
Constant Rate ◽  
Rate Infusion

scholarly journals Stage 1-Biomarkers of Kidney Injury in Dogs Undergoing Constant Rate Infusion of Hydroxyethyl Starch 130/0.4

Animals ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2555
Author(s):  
Barbara Bruno ◽  
Roberta Troìa ◽  
Francesco Dondi ◽  
Cristiana Maurella ◽  
Paola Gianella ◽  
...  
Keyword(s):  
Hydroxyethyl Starch ◽  
Kidney Injury ◽  
Fractional Excretion ◽  
Creatinine Ratio ◽  
Constant Rate Infusion ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Constant Rate ◽  
Significant Difference ◽  
Stage 1 ◽  
Rate Infusion

In veterinary medicine, investigations relating the effects of hydroxyethyl starch (HES) on renal function report contrasting results. This study aimed to assess the changes in the selected biomarkers of kidney injury in dogs after the administration of HES 130/0.4 as a constant rate infusion (CRI) for 24 h. Ten adult client-owned dogs with hypoalbuminemia (albumin < 2 g/dL) and ongoing fluid losses were included. Enrolled dogs received intravenous fluid therapy with crystalloids and a CRI of HES 130/0.4 at a dose of 2 mL/kg/h for 24 h. Serum creatinine (sCr), fractional excretion (FE) of electrolytes, urinary protein to creatinine ratio (UPC), urinary albumin to creatinine ratio (UAC), SDS-page, and urinary neutrophil gelatinase-associated lipocalin (uNGAL) were measured at the baseline before HES infusion, and after 24 h (T24) and 48 h (T48) from the baseline. No statistically significant difference was found between the baseline value vs. T24 and the baseline vs. T48 for sCr, UAC, UPC, FE of sodium, chloride and calcium, and uNGAL. A significant increase in FEK (p = 0.04) was noticed between the baseline and T48. In this study sample of hypoalbuminemic dogs, HES 130/0.4 at the dose and rate of infusion applied did not cause any significant changes in the investigated biomarkers of kidney injury.

Counterregulation of insulin-induced hypoglycaemia in primary hypothyroidism

1986 ◽  
Vol 111 (4) ◽  
pp. 516-521
Author(s):  
Nina Clausen ◽  
Per-Eric Lins ◽  
Ulf Adamson ◽  
Bertil Hamberger ◽  
Suad Efendić
Keyword(s):  
Growth Hormone ◽  
Insulin Infusion ◽  
Primary Hypothyroidism ◽  
Constant Rate Infusion ◽  
Counterregulatory Hormones ◽  
Insulin Metabolism ◽  
Hormonal Responses ◽  
Glucose Levels ◽  
Constant Rate ◽  
Rate Infusion

Abstract. Hypothyroidism has been alleged to modulate insulin action and influence the secretion of growth hormone and catecholamines. We recently investigated the influence of hypothyroidism on glucose counterregulatory capacity and the hormonal responses to insulin-induced hypoglycaemia in 6 patients with primary hypothyroidism (age 32–52 years, TSH-values 66–200 mU/l). Hypoglycaemia was induced in the hypothyroid state and again when the subjects were euthyroid. After an overnight fast a constant rate infusion of insulin (2.4 U/h) was given for 4 h. Glucose was measured every 15 min and insulin, C-peptide, glucagon, epinephrine, norepinephrine, growth hormone and cortisol every 30 min for 5 h. During insulin infusion somewhat higher concentrations of the hormone were obtained in the hypothyroid state and simultaneously glucose levels were 0.5 mmol/l lower. As expected, basal norepinephrine levels were higher in hypothyroidism. However, no increase in circulating norepinephrine during hypoglycaemia was registered in the two experiments. The responses of counterregulatory hormones showed an enhanced response of cortisol, similar responses of growth hormone and epinephrine while the glucagon response was paradoxically impaired. Our findings suggest that hypothyroidism alters insulin metabolism, and that the glucagon response to hypoglycaemia is impaired in this condition.

Pharmacokinetics and pharmacodynamics of a constant rate infusion of fentanyl (5 μg/kg/h) in awake cats

2014 ◽  
Vol 75 (8) ◽  
pp. 716-721 ◽  
Author(s):  
Barbara Ambros ◽  
Jane Alcorn ◽  
Tanya Duke-Novakovski ◽  
Alexander Livingston ◽  
Patricia M. Dowling
Keyword(s):  
Pharmacokinetics And Pharmacodynamics ◽  
Constant Rate Infusion ◽  
Constant Rate ◽  
Awake Cats ◽  
Rate Infusion

Anaesthetic and cardiorespiratory effects of a constant-rate infusion of alfaxalone in desflurane-anaesthetised sheep

2012 ◽  
Vol 171 (5) ◽  
pp. 125-125 ◽  
Author(s):  
M. del Mar Granados ◽  
J. Manuel Domínguez ◽  
A. Fernández-Sarmiento ◽  
F. Javier Funes ◽  
J. Morgaz ◽  
...  
Keyword(s):  
Constant Rate Infusion ◽  
Constant Rate ◽  
Rate Infusion

Comparison of three plasma expanders used as priming fluids in cardiopulmonary bypass patients

Perfusion ◽  
1998 ◽  
Vol 13 (5) ◽  
pp. 297-303 ◽  
Author(s):  
Izaak Tigchelaar ◽  
Rolf CG Gallandat Huet ◽  
Piet W Boonstra ◽  
Willem van Oeveren
Keyword(s):  
Cardiopulmonary Bypass ◽  
Osmotic Pressure ◽  
Hydroxyethyl Starch ◽  
Half Life ◽  
Human Albumin ◽  
Colloid Osmotic Pressure ◽  
Low Molecular Weight ◽  
Postoperative Phase ◽  
Total Blood ◽  
Plasma Substitute

Ten per cent low molecular weight hydroxyethyl starch is a plasma substitute only recently used as priming solution in an extracorporeal circuit, in contrast to human albumin and gelatin. To evaluate the effect of priming solutions on haemodynamics and colloid osmotic pressure, we studied 36 patients elected for cardiopulmonary bypass (CPB). They were randomly assigned to 2.5% hydroxyethyl starch, 3% gelatin or 4% human albumin priming solution. Total blood loss (perioperative + intensive care unit period) was higher in the gelatin group than in the albumin and hydroxyethyl starch groups. During CPB, the colloid osmotic pressure was best preserved in the gelatin group, although no excessively low colloid osmotic pressures were measured in the other two groups. Due to the extended half-life and the additional postoperative colloid administration, the hydroxyethyl starch group had a higher colloid osmotic pressure in the postoperative phase. We conclude that, next to human albumin, 2.5% hydroxyethyl starch is a safe CPB priming solution additive and is effective as plasma substitute. Its somewhat longer half-life requires adaptation of the routine protocol for transfusion of colloids and blood products.

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