Bone marrow, blood, and clinical findings in dogs treated with phenobarbital

2021 ◽  
Vol 50 (1) ◽  
pp. 122-131
Author(s):  
Tiffany N. Scott ◽  
H. Grady Bailin ◽  
L. Ari Jutkowitz ◽  
Michael A. Scott ◽  
Cynthia A. Lucidi
Keyword(s):  
Bone Marrow ◽  
Clinical Findings ◽  
Bone Marrow Blood

Bone and Bone Marrow Blood Flow in Blastic Crisis of Chronic Granulocytic Leukaemia

1979 ◽  
Vol 18 (06) ◽  
pp. 290-292 ◽  
Author(s):  
R. Lahtinen ◽  
T. Lahtinen
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Blood Flow ◽  
Proximal Femur ◽  
Blastic Crisis ◽  
Normal Bone ◽  
Chronic Granulocytic Leukaemia ◽  
Washout Curves ◽  
Bone Marrow Blood

SummaryA l33Xe washout method has been used for measuring changes of blood flow in the proximal femur of a patient with the blastic crisis of chronic granulocytic leukaemia. In the hyperplastic phase the blood flow was highly increased and over three times greater than in the hypoplastic phase of the disease and over thirteen times greater than the value in normal bone. The bone circulation and especially the first component of the two-exponential bone washout curves appeared to reflect cell proliferation and neoplastic activity of the whole bone marrow. The method may provide clinically important information in the follow-up of selected haematological diseases.

scholarly journals Determinants of Erythrocyte Size in Chronic Liver Disease

Blood ◽  
1969 ◽  
Vol 34 (6) ◽  
pp. 739-746 ◽  
Author(s):  
THOMAS M. KILBRIDGE ◽  
PAUL HELLER
Keyword(s):  
Bone Marrow ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Peripheral Blood ◽  
Hepatic Cirrhosis ◽  
Alcoholic Cirrhosis ◽  
Clinical Findings ◽  
Red Cells ◽  
Red Cell ◽  
Cell Volumes

Abstract Serial determinations of red cell volumes were made with an electronic sizing device in 30 patients with hepatic cirrhosis. Variations in red cell volumes were correlated with other hematologic and clinical findings. The results of these studies suggest that volume macrocytosis in patients with alcoholic cirrhosis is either due to megaloblastosis of the bone marrow or to an accelerated influx of young red cells into the peripheral blood.

PREDNISONE IN CHILDHOOD LEUKEMIA

PEDIATRICS ◽  
1959 ◽  
Vol 24 (6) ◽  
pp. 1005-1008
Author(s):  
Carol B. Hyman ◽  
Eduardo Borda C ◽  
Charles Brubaker ◽  
Denman Hammond ◽  
Phillip Sturgeon
Keyword(s):  
Bone Marrow ◽  
Childhood Leukemia ◽  
Therapy Group ◽  
Continuous Therapy ◽  
Reduced Dose ◽  
Lymphatic Leukemia ◽  
Clinical Control ◽  
Physical Findings ◽  
Serial Evaluation ◽  
Bone Marrow Blood

Thirty children with acute lymphatic leukemia were treated with 2.2 mg/kg/day of prednisone for 28 days. After this initial course, they were alternately given interrupted or continuous therapy. In the group receiving the interrupted therapy, the dose was gradually discontinued over the succeeding 5 to 7 days. In the continuous therapy group, prednisone was continued, but at a reduced dose of 0.55 mg/kg/day. Both groups were followed by serial evaluation of the bone marrow, blood, physical findings and symptoms. The therapy period was considered terminated when relapse occurred as judged by the bone marrow. The groups did not differ significantly in the number of remissions induced, their duration, or the duration of clinical control. One patient in each group failed to obtain a remission of any degree. These studies do not indicate any advantage for continuous therapy over interrupted therapy with prednisone. On the other hand, with continuous therapy, there are the disadvantages of increased side-effects, higher cost, and the probability of permanent refractoriness to the drug.

scholarly journals Evaluation of the Effect of Shenmai Injection on Chemotherapy Efficacy and Side Effects of Acute Leukemia

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Jianling Qiao ◽  
Xuan Kan ◽  
Fei Qin
Keyword(s):  
Bone Marrow ◽  
Side Effects ◽  
Acute Leukemia ◽  
Control Group ◽  
Blood Levels ◽  
Observation Group ◽  
Impaired Liver Function ◽  
Shenmai Injection ◽  
Before And After ◽  
Bone Marrow Blood

Objective: To study the effect of Shenmai injection on the efficacy and side effects of chemotherapy in acute leukemia. Methods: Sixty-two patients with acute leukemia admitted to the hospital between February 2018 and June 2019 were enrolled in this study. All patients were divided into observation and control groups according to different treatment methods in chemotherapy. The control group was treated with chemotherapy alone. The observation group was treated Shenmai injection combined with chemotherapy. The treatment effect of the two groups was compared, and the incidence of bone marrow blood and side effects before and after treatment were compared. Results: The therapeutic effect of the observation group was 93.55% which was much higher than that of the control group of 74.19%, P<0.05. The bone marrow blood levels of WBC, PLT and Hb in the observation group before and after treatment were 23.97±3.05, 6.76±1.27, 69.01±8.15, 66.96±9.46, 91.07±8.15, 89.35±7.46, respectively, compared with the control group. The difference in the situation after treatment was found to be significant. The incidence of toxic side effects such as nausea and vomiting, impaired liver function and renal dysfunction in the observation group was 9.68%, which was lower than that of the control group (32.26%, P<0.05). Conclusion: Shemai injection has significant effects on the efficacy and side effects of chemotherapy in acute leukemia and effectively improves the effect of chemotherapy.

Hemophagocytosis or emperipolesis by lymphoblast after rapid transformation of chronic myeloid leukemia

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
João Lucas Cruz-Souza ◽  
◽  
Fernanda Paula de Carvalho ◽  
Márcio Antonio Wanderley de Melo ◽  
Edinalva Pereira Leite ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Myeloid Leukemia ◽  
Outpatient Visit ◽  
Clinical Findings ◽  
Myelogenous Leukemia ◽  
Bone Marrow Aplasia ◽  
Hla Dr ◽  
Consolidation Phase ◽  
Blast Cells ◽  
Rapid Transformation

A Male, 11-Years-Old, Admitted In March 2019 With Chronic myelogenous leukemia (CML) in treatment with Imatinib. Three months after diagnosis in outpatient visit was observed increase of splenomegaly and appearing of inguinal and cervical adenomegalies. Bone marrow apiration revealed 70% of blasts, some of them with hemophagocytosis (Figure 1). The immunophenotyping showed blasts positive for CD10, CD19, CD20, CD22, CD79a, CD45, HLA-DR, indicating transformation to B precursors ALL. Bone marrow karyotype was 46,XY,t(9;22), FISH (BCR-ABLES probe) confirmed rearrangement with p210. The patient was treated with higher dose of Imatinib (600 mg/m²), but evolved with bone marrow aplasia and infectious process, being then reajusted to 400 mg/m² with clinical and hematologic improvement. After 30 days had disease aggravation and resistance to Imatinib. The patient initiated EsPh-ALL 2009 protocol, but in D33 with no remission of disease continued with protocol. In September, during consolidation phase evolved with Central Nervous System infiltration and disease persistence, dying for disease in progress. This patient had no clinical findings of Hemophagocytic Lymphohistiocytosis (HLH) and bone marrow cytology showed the several hematopoietic cells inside blast cells.

Multiple Myeloma Prediction from Bone-Marrow Blood Cell images using Machine Learning

2021 ◽  
Author(s):  
Sai Pavan Kamma ◽  
Guru Sai Sharma Chilukuri ◽  
Guru Sree Ram Tholeti ◽  
Rudra Kalyan Nayak ◽  
Tapaswi Maradani
Keyword(s):  
Machine Learning ◽  
Multiple Myeloma ◽  
Bone Marrow ◽  
Blood Cell ◽  
Bone Marrow Blood

scholarly journals ISOLATION OF MONONUCLEAR CELLS FROM BONE MARROW BLOOD FOR BONE MARROW TRANSPLANTATION USING SEPAXTM

2012 ◽  
Vol 58 (3) ◽  
pp. 456-462
Author(s):  
Koji Kishino ◽  
Yoko Nakaki ◽  
Fumiko Onozaki ◽  
Seiko Shindou ◽  
Ikuko Otsuki ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Mononuclear Cells ◽  
Bone Marrow Blood

scholarly journals THE RESPONSE OF EOSINOPHILS IN THE GUINEA PIG TO SENSITIZATION, ANAPHYLAXIS AND VARIOUS DRUGS

Blood ◽  
1949 ◽  
Vol 4 (3) ◽  
pp. 217-246 ◽  
Author(s):  
MAX SAMTER
Keyword(s):  
Bone Marrow ◽  
Guinea Pig ◽  
Eosinophil Count ◽  
Guinea Pigs ◽  
Specific Antigen ◽  
Wide Range ◽  
The Individual ◽  
Bone Marrow Blood ◽  
Antihistamine Drugs ◽  
Definite Correlation

Abstract 1. The eosinophilic response of the guinea pig sensitized and reinjected with the specific antigen varies with the nature of the antigen used, but also with the individual guinea pig in any groupsensitized and reinjected with the same antigen. 2. Certain antihistamine drugs which abolish anaphylactic symptoms, do not abolish the eosinophilic response. 3. The severity of anaphylactic "shock" symptoms has no influence on the eosinophilic response. 4. Histamine phosphate has no effect on the eosinophil count of nonsensitized guinea pigs protected by benadryl; it causes a distinct eosinophilic response in sensitized animals. 5. Heparin—in the dose injected—produced only an insignificant rise in the peripheral eosinophil count of sensitized guinea pigs; adenosine had no effect. 6. Attempts were made to correlate the eosinophilic response in bone marrow, blood and shock tissue of guinea pigs sensitized and reinjected with a specific antigen. The variation within a wide range of the number of eosinophils in the bone marrow of nonsensitized and of sensitized, reinjected guinea pigs is emphasized. A definite correlation seems to exist between the presence of a large number of eosinophils in blood and lungs; it is shown, however, that this observation permits only limited conclusions. 7. The factors which account for discrepancies in the interpretation of the eosinophilic response, e.g., nature of antigen, route of administration and characteristics of species, are analyzed. 8. The significance of the findings is reviewed in the light of previous work.

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