scholarly journals Familial follicular cell thyroid carcinomas in a large number of Dutch German longhaired pointers

2021 ◽  
Author(s):  
Yun Yu ◽  
Adriana Krupa ◽  
Rebekah I. Keesler ◽  
Guy C. M. Grinwis ◽  
Mariska Ruijsscher ◽  
...  
Keyword(s):  
Follicular Cell ◽  
Thyroid Carcinomas

Prognostic significance of TERT promoter mutations in follicular cell-derived thyroid carcinomas

2014 ◽  
Author(s):  
Miguel Melo ◽  
Rocha Adriana Gaspar da ◽  
Joao Vinagre ◽  
Rui Batista ◽  
Joana Peixoto ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Follicular Cell ◽  
Thyroid Carcinomas ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

Problems and Controversies in the Histopathology of Thyroid Carcinomas of Follicular Cell Origin

2009 ◽  
Vol 133 (5) ◽  
pp. 683-691
Author(s):  
Ronald Ghossein
Keyword(s):  
Thyroid Carcinoma ◽  
English Language ◽  
Follicular Carcinoma ◽  
Molecular Data ◽  
Follicular Cell ◽  
Clinical Value ◽  
Thyroid Carcinomas ◽  
Poorly Differentiated ◽  
Disease Entities

Abstract Context.—Despite past and recent efforts, many problems and controversies remain in the classification of thyroid carcinomas of follicular cell origin. These controversies have an impact on the prognosis and therapy of patients with thyroid carcinoma as well as on the development of robust cutting-edge research aimed at better outcome and quality of life. Objective.—To focus on 3 contentious areas with significant clinical value: the follicular variant of papillary thyroid carcinoma, the extent of invasion in follicular carcinoma, and the poorly differentiated thyroid carcinomas. Data Sources.—The published English language literature was reviewed. Conclusions.—Recent data show that prognosis and therapy for many disease entities can be better delineated if a meticulous microscopic examination is performed. An accurate assessment of the extent of invasion (especially vascular) is crucial. Proliferative grading (ie, mitosis and necrosis) is of high prognostic value and should be looked for in every specimen. In addition, molecular data gathered to date can help reassess these tumors at the histologic level. Classification proposals based on personal experience rather than adequate and careful clinical follow-up should be discouraged.

scholarly journals Signaling pathways in follicular cell-derived thyroid carcinomas

2012 ◽  
Vol 42 (1) ◽  
pp. 19-28 ◽  
Author(s):  
MÍRIAN ROMITTI ◽  
LUCIELI CEOLIN ◽  
DÉBORA RODRIGUES SIQUEIRA ◽  
CARLA VAZ FERREIRA ◽  
SIMONE MAGAGNIN WAJNER ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Follicular Cell ◽  
Thyroid Carcinomas

scholarly journals Aggressive variants of follicular cell-derived thyroid carcinomas: A cytopathologist's perspective

2014 ◽  
Vol 122 (7) ◽  
pp. 484-503 ◽  
Author(s):  
Ricardo R. Lastra ◽  
Virginia A. LiVolsi ◽  
Zubair W. Baloch
Keyword(s):  
Follicular Cell ◽  
Thyroid Carcinomas

scholarly journals Clinicopathologic Features of Fatal Non-Anaplastic Follicular Cell–Derived Thyroid Carcinomas

Thyroid ◽  
2016 ◽  
Vol 26 (11) ◽  
pp. 1588-1597 ◽  
Author(s):  
Bin Xu ◽  
Tihana Ibrahimpasic ◽  
Laura Wang ◽  
Mona M. Sabra ◽  
Jocelyn C. Migliacci ◽  
...  
Keyword(s):  
Follicular Cell ◽  
Clinicopathologic Features ◽  
Thyroid Carcinomas

Different genotype distribution of theGNB3 C825T polymorphism of the G protein β3 subunit in adenomas and differentiated thyroid carcinomas of follicular cell origin

2005 ◽  
Vol 207 (4) ◽  
pp. 430-435 ◽  
Author(s):  
Sien-Yi Sheu ◽  
Rainer Görges ◽  
Christian Ensinger ◽  
Dietmar Öfner ◽  
Nadir R Farid ◽  
...  
Keyword(s):  
G Protein ◽  
Follicular Cell ◽  
Genotype Distribution ◽  
Thyroid Carcinomas ◽  
C825t Polymorphism

A patient presenting with spinal cord compression who had two distinct follicular cell type thyroid carcinomas

2004 ◽  
Vol 27 (6) ◽  
pp. 562-564 ◽  
Author(s):  
E. Koca ◽  
C. Sokmensuer ◽  
B. O. Yildiz ◽  
H. Engin ◽  
M. F. Bozkurt ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Follicular Cell ◽  
Cell Type ◽  
Thyroid Carcinomas

scholarly journals Familial thyroid follicular cell carcinomas in a large number of Dutch German longhaired pointers

2021 ◽  
Author(s):  
Yun Yu ◽  
Adriana Krupa ◽  
Rebekah I. Keesler ◽  
Guy C. M. Grinwis ◽  
Mariska de Ruijsscher ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Genetic Basis ◽  
Inbreeding Coefficient ◽  
Follicular Cell ◽  
Follicular Cells ◽  
Thyroid Follicular Cell ◽  
Thyroid Carcinomas ◽  
The Past ◽  
Age Of Diagnosis ◽  
Follicular Cell Carcinoma

AbstractThyroid carcinomas originating from follicular cells of the thyroid gland occur in both humans and dogs and they have highly similar histomorphologic patterns. In dogs, thyroid carcinomas have not been extensively investigated, especially concerning the familial origin of thyroid carcinomas. Here we report familial thyroid follicular cell carcinomas confirmed by histology in 54 Dutch origin German longhaired pointers. From the pedigree, 45 of 54 histopathologically confirmed cases are closely related to a pair of first-half cousins in the past, indicating a familial disease. In addition, genetics contributed more to the thyroid follicular cell carcinoma than other factors by an estimated heritability of 0.62 based on pedigree. The age of diagnosis ranged between 4.5 and 13.5 years, and 76% of cases were diagnosed before 10 years of age, implying an early onset of disease. We observed a significant higher pedigree-based inbreeding coefficient in the affected dogs (mean F 0.23) compared to unaffected dogs (mean F 0.14), suggesting the contribution of inbreeding to tumour development. The unique occurrence of familial thyroid follicular cell carcinoma in this dog population and the large number of affected dogs make this population an important model to identify the genetic basis of familial thyroid follicular cell carcinoma in this breed and may contribute to the research into pathogenesis, prevention and treatment in humans.

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