Negative impact of prolonged cold storage time before machine perfusion preservation in donation after circulatory death kidney transplantation

2016 ◽  
Vol 29 (10) ◽  
pp. 1117-1125 ◽  
Author(s):  
Siegfredo Paloyo ◽  
Junichiro Sageshima ◽  
Jeffrey J. Gaynor ◽  
Linda Chen ◽  
Gaetano Ciancio ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Cold Storage ◽  
Storage Time ◽  
Negative Impact ◽  
Machine Perfusion ◽  
Donation After Circulatory Death ◽  
Circulatory Death

scholarly journals Normothermic Ex Vivo Machine Perfusion for Liver Grafts Recovered from Donors after Circulatory Death: A Systematic Review and Meta-Analysis

HPB Surgery ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Jordan J. Nostedt ◽  
Daniel T. Skubleny ◽  
A. M. James Shapiro ◽  
Sandra Campbell ◽  
Darren H. Freed ◽  
...  
Keyword(s):  
Cold Storage ◽  
Meta Analysis ◽  
Mean Difference ◽  
Large Animal ◽  
Machine Perfusion ◽  
Donation After Circulatory Death ◽  
Economic Implications ◽  
Normothermic Perfusion ◽  
Normothermic Machine Perfusion ◽  
Circulatory Death

As a result of donation after circulatory death liver grafts’ poor tolerance to cold storage, there has been increasing research interest in normothermic machine perfusion. This study aims to systematically review the current literature comparing normothermic perfusion to cold storage in donation after circulatory death liver grafts and complete a meta-analysis of published large animal and human studies. A total of nine porcine studies comparing cold storage to normothermic machine perfusion for donation after circulatory death grafts were included for analysis. There was a significant reduction in AST (mean difference −2291 U/L, CI (−3019, −1563); P ≤ 0.00001) and ALT (mean difference −175 U/L, CI (−266, −85); P=0.0001), for normothermic perfusion relative to static cold storage, with moderate (I2 = 61%) and high (I2 = 96%) heterogeneity, respectively. Total bile production was also significantly higher (mean difference = 174 ml, CI (155, 193); P≤0.00001). Further research focusing on standardization, performance of this technology following periods of cold storage, economic implications, and clinical trial data focused on donation after circulatory death grafts will be helpful to advance this technology toward routine clinical utilization for these grafts.

Normothermic regional perfusion vs. super-rapid retrieval in controlled donation after circulatory death: Different outcomes in kidney transplantation?

2021 ◽  
Vol 79 ◽  
pp. S494-S495
Author(s):  
R. Chaves Marcos ◽  
B.T. Antón Eguía ◽  
A. Cuevas Palomino ◽  
M.D.L. Parra Lopez ◽  
P. Rodriguez Marcos ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Regional Perfusion ◽  
Donation After Circulatory Death ◽  
Normothermic Regional Perfusion ◽  
Circulatory Death

scholarly journals Recommendations for donation after circulatory death kidney transplantation in Europe

2015 ◽  
Vol 29 (7) ◽  
pp. 780-789 ◽  
Author(s):  
L. W.Ernest van Heurn ◽  
David Talbot ◽  
Michael L. Nicholson ◽  
Mohammed Z. Akhtar ◽  
Ana I. Sanchez-Fructuoso ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Donation After Circulatory Death ◽  
Circulatory Death
Sign in / Sign up

Export Citation Format

Share Document