scholarly journals Outcomes of donation after circulatory death kidneys undergoing hypothermic machine perfusion following static cold storage: A UK population-based cohort study

2017 ◽  
Vol 18 (6) ◽  
pp. 1408-1414 ◽  
Author(s):  
Kamlesh Patel ◽  
Jay Nath ◽  
James Hodson ◽  
Nicholas Inston ◽  
Andrew Ready
Keyword(s):  
Cohort Study ◽  
Cold Storage ◽  
Population Based ◽  
Machine Perfusion ◽  
Donation After Circulatory Death ◽  
Hypothermic Machine Perfusion ◽  
Circulatory Death

scholarly journals Effects of Oxygen During Long-term Hypothermic Machine Perfusion in a Porcine Model of Kidney Donation After Circulatory Death

2019 ◽  
Vol 103 (10) ◽  
pp. 2057-2064 ◽  
Author(s):  
Leonie H. Venema ◽  
Aukje Brat ◽  
Cyril Moers ◽  
Nils A. ‘t Hart ◽  
Rutger J. Ploeg ◽  
...  
Keyword(s):  
Porcine Model ◽  
Kidney Donation ◽  
Machine Perfusion ◽  
Donation After Circulatory Death ◽  
Hypothermic Machine Perfusion ◽  
Circulatory Death

scholarly journals Normothermic Ex Vivo Machine Perfusion for Liver Grafts Recovered from Donors after Circulatory Death: A Systematic Review and Meta-Analysis

HPB Surgery ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Jordan J. Nostedt ◽  
Daniel T. Skubleny ◽  
A. M. James Shapiro ◽  
Sandra Campbell ◽  
Darren H. Freed ◽  
...  
Keyword(s):  
Cold Storage ◽  
Meta Analysis ◽  
Mean Difference ◽  
Large Animal ◽  
Machine Perfusion ◽  
Donation After Circulatory Death ◽  
Economic Implications ◽  
Normothermic Perfusion ◽  
Normothermic Machine Perfusion ◽  
Circulatory Death

As a result of donation after circulatory death liver grafts’ poor tolerance to cold storage, there has been increasing research interest in normothermic machine perfusion. This study aims to systematically review the current literature comparing normothermic perfusion to cold storage in donation after circulatory death liver grafts and complete a meta-analysis of published large animal and human studies. A total of nine porcine studies comparing cold storage to normothermic machine perfusion for donation after circulatory death grafts were included for analysis. There was a significant reduction in AST (mean difference −2291 U/L, CI (−3019, −1563); P ≤ 0.00001) and ALT (mean difference −175 U/L, CI (−266, −85); P=0.0001), for normothermic perfusion relative to static cold storage, with moderate (I2 = 61%) and high (I2 = 96%) heterogeneity, respectively. Total bile production was also significantly higher (mean difference = 174 ml, CI (155, 193); P≤0.00001). Further research focusing on standardization, performance of this technology following periods of cold storage, economic implications, and clinical trial data focused on donation after circulatory death grafts will be helpful to advance this technology toward routine clinical utilization for these grafts.

Negative impact of prolonged cold storage time before machine perfusion preservation in donation after circulatory death kidney transplantation

2016 ◽  
Vol 29 (10) ◽  
pp. 1117-1125 ◽  
Author(s):  
Siegfredo Paloyo ◽  
Junichiro Sageshima ◽  
Jeffrey J. Gaynor ◽  
Linda Chen ◽  
Gaetano Ciancio ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Cold Storage ◽  
Storage Time ◽  
Negative Impact ◽  
Machine Perfusion ◽  
Donation After Circulatory Death ◽  
Circulatory Death

Influence of Oxygen Concentration During Hypothermic Machine Perfusion on Porcine Kidneys From Donation After Circulatory Death

2014 ◽  
Vol 98 (9) ◽  
pp. 944-950 ◽  
Author(s):  
Dieter P. Hoyer ◽  
Anja Gallinat ◽  
Sandra Swoboda ◽  
Jeremias Wohlschlaeger ◽  
Ursula Rauen ◽  
...  
Keyword(s):  
Oxygen Concentration ◽  
Machine Perfusion ◽  
Donation After Circulatory Death ◽  
Hypothermic Machine Perfusion ◽  
Circulatory Death
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