Auxiliary liver transplantation with a small deceased liver graft for cirrhotic liver complicated by hepatocellular carcinoma

2013 ◽  
Vol 26 (11) ◽  
pp. e102-e104 ◽  
Author(s):  
Safi Dokmak ◽  
Laure Elkrief ◽  
Jacques Belghiti
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Cirrhotic Liver ◽  
Liver Graft ◽  
Auxiliary Liver Transplantation

Immune Checkpoint Inhibitors in Patients with Recurrent Hepatocellular Carcinoma after Liver Transplantation: A Case Report and Literature Review

2020 ◽  
Vol 20 (9) ◽  
pp. 720-727
Author(s):  
Jianguo Qiu ◽  
Wei Tang ◽  
Chengyou Du
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Immune Checkpoint ◽  
Graft Rejection ◽  
Checkpoint Inhibitors ◽  
Liver Graft ◽  
Immune Checkpoints ◽  
Term Survival ◽  
Liver Preservation ◽  
Programmed Death

Background: Immune checkpoint modulators, such as the programmed death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitor, cytotoxic T-Lymphocyte-associated antigen 4 (CTLA-4) inhibitor have been investigated with encouraging results for hepatocellular carcinoma (HCC). However, the safety of this strategy in patients with previous liver transplantation (LT) is not well studied. Objective: To explore the safety and feasibility of immune checkpoints inhibitors in recurrent and metastatic HCC patients on a background of LT. Methods: A case of recurrent, refractory, metastatic HCC after LT, where PD-1 inhibitor was initiated, was described and related literature was reviewed. Results: There was complete remission in lung metastases and the partial radiological response of metastatic retroperitoneal lymph node to the drug with no liver graft rejection after 13 cycles of PD- 1 inhibitor injection. PD-1inhibitor, at least in this patient, was verified to play an important role in controlling tumor progression and prolonging patient survival. Conclusions: This novel drug might be a useful method to allow doctors to guarantee a better chance for long-term survival in recurrent, metastatic HCC patients with the previous LT. However, it should be used with caution in allograft recipients due to the risk of acute graft rejection, further larger, prospective studies are needed to determine optimal immunomodulatory therapy to achieve optimal anti-tumor efficacy with transplant liver preservation.

Liver transplantation in children with hepatocellular carcinoma on cirrhotic liver

2007 ◽  
Vol 39 (10) ◽  
pp. A44
Author(s):  
D. Pinelli ◽  
M. Guizzetti ◽  
M. Zambelli ◽  
V. Corno ◽  
A. Lucianetti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Cirrhotic Liver

scholarly journals Mortality after Transplantation for Hepatocellular Carcinoma: A Study from the European Liver Transplant Registry

Liver Cancer ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 455-467
Author(s):  
Hans-Christian Pommergaard ◽  
Andreas Arendtsen Rostved ◽  
René Adam ◽  
Mauro Salizzoni ◽  
Miguel Angel Gómez Bravo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Cirrhotic Liver ◽  
Unmeasured Confounding ◽  
Increased Risk ◽  
Specific Mortality ◽  
Transplant Registry ◽  
Cirrhotic Patients ◽  
Overall Mortality

Background and Aims: Prognosis after liver transplantation differs between hepatocellular carcinoma (HCC) arising in cirrhotic and non-cirrhotic livers and aetiology is poorly understood. The aim was to investigate differences in mortality after liver transplantation between these patients. Methods: We included patients from the European Liver Transplant Registry transplanted due to HCC from 1990 to November 2016 and compared cirrhotic and non-cirrhotic patients using propensity score (PS) calibration of Cox regression estimates to adjust for unmeasured confounding. Results: We included 22,787 patients, of whom 96.5% had cirrhosis. In the unadjusted analysis, non-cirrhotic patients had an increased risk of overall mortality with a hazard ratio (HR) of 1.37 (95% confidence interval [CI] 1.23–1.52). However, the HR approached unity with increasing adjustment and was 1.11 (95% CI 0.99–1.25) when adjusted for unmeasured confounding. Unadjusted, non-cirrhotic patients had an increased risk of HCC-specific mortality (HR 2.62, 95% CI 2.21–3.12). After adjustment for unmeasured confounding, the risk remained significantly increased (HR 1.62, 95% CI 1.31–2.00). Conclusions: Using PS calibration, we showed that HCC in non-cirrhotic liver has similar overall mortality, but higher HCC-specific mortality. This may be a result of a more aggressive cancer form in the non-cirrhotic liver as higher mortality could not be explained by tumour characteristics or other prognostic variables.

Liver Transplantation After Downstagings of Ruptured Advanced Hepatocellular Carcinoma in Cirrhotic Liver: Is It Advisable? A Case Report

2019 ◽  
Vol 51 (5) ◽  
pp. 1468-1471 ◽  
Author(s):  
Kuo-Shyang Jeng ◽  
Chun-Chieh Huang ◽  
Chien-Chu Lin ◽  
Cheng-Kuan Lin ◽  
Chung-Jen Teng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Case Report ◽  
Cirrhotic Liver ◽  
Advanced Hepatocellular Carcinoma

scholarly journals Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis

2018 ◽  
Vol 28 (4) ◽  
pp. 76-83
Author(s):  
O. D. Olisov ◽  
M. S. Novruzbekov ◽  
I. E. Galankina ◽  
L. N. Zimina ◽  
V. A. Gulyaev ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Cirrhosis ◽  
Normal Liver ◽  
Chronic Viral Hepatitis ◽  
Cirrhotic Liver ◽  
Control Group ◽  
Large Tumor ◽  
Unresectable Hepatocellular Carcinoma

Aim. The aim of the study is to determine the effectiveness of liver transplantation (LT) in the treatment of unresectable hepatocellular carcinoma (HCC) occurred in normal liver.Material and methods.  6 patients with unresectable HCC underwent orthotopic liver transplantation (OLT). The long-term OLT results were compared with survival results of liver resection in patients with late stage HCC.Results.  Hepatocellular carcinoma is one of the most common types of cancer, which occurs mainly in patients with liver cirrhosis and chronic viral hepatitis. Only about 10 % of HCC develops in non-cirrhotic liver among young and somatically healthy patients. 1-, 3-, 5-year recurrence-free and overall survival in LT group was significantly better than in the control group.Conclusion.  LT is indicated for patients with unresectable HCC in non-cirrhotic liver and its extrahepatic localization. A large tumor size and macrovascular invasion should not be a contraindication for LT in such patients. 

scholarly journals Simplified technique for auxiliary orthotopic liver transplantation using a whole graft

2015 ◽  
Vol 28 (2) ◽  
pp. 136-138 ◽  
Author(s):  
Vinicius ROCHA-SANTOS ◽  
Lucas Souto NACIF ◽  
Rafael Soares PINHEIRO ◽  
Liliana DUCATTI ◽  
Wellington ANDRAUS ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Orthotopic Liver Transplantation ◽  
Hemodynamic Instability ◽  
Liver Graft ◽  
Alternative Technique ◽  
Patient Death ◽  
First Case ◽  
Auxiliary Liver Transplantation

BACKGROUND: Acute liver failure is associated with a high mortality rate and the main purposes of treatment are to prevent cerebral edema and infections, which often are responsible for patient death. The orthotopic liver transplantation is the gold standard treatment and improves the 1-year survival. AIM: To describe an alternative technique to auxiliary liver transplant on acute liver failure. METHOD: Was performed whole auxiliary liver transplantation as an alternative technique for a partial auxiliary liver transplantation using a whole liver graft from a child removing the native right liver performed a right hepatectomy. The patient met the O´Grady´s criteria and the rational to indicate an auxiliary orthotopic liver transplantation was the acute classification without hemodynamic instability or renal failure in a patient with deterioration in consciousness. RESULTS: The procedure improved liver function and decreased intracranial hypertension in the postoperative period. CONCLUSION: This technique can overcome some postoperative complications that are associated with partial grafts. As far as is known, this is the first case of auxiliary orthotopic liver transplantation in Brazil.

miR-203 expression predicts outcome after liver transplantation for hepatocellular carcinoma in cirrhotic liver

2011 ◽  
Vol 29 (3) ◽  
pp. 1859-1865 ◽  
Author(s):  
Hong-Yuan Chen ◽  
Zhong-Bo Han ◽  
Jun-Wei Fan ◽  
Jun Xia ◽  
Jun-Yi Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Cirrhotic Liver

scholarly journals Complete spontaneous liver graft disappearance after auxiliary liver transplantation

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 1104-1106 ◽  
Author(s):  
Safi Dokmak ◽  
Béatrice Aussilhou ◽  
François Durand ◽  
Valérie Paradis ◽  
Jacques Belghiti
Keyword(s):  
Liver Transplantation ◽  
Liver Graft ◽  
Auxiliary Liver Transplantation
Sign in / Sign up

Export Citation Format

Share Document