Liver transplantation in children with hepatocellular carcinoma on cirrhotic liver

2007 ◽  
Vol 39 (10) ◽  
pp. A44
Author(s):  
D. Pinelli ◽  
M. Guizzetti ◽  
M. Zambelli ◽  
V. Corno ◽  
A. Lucianetti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Cirrhotic Liver

scholarly journals Mortality after Transplantation for Hepatocellular Carcinoma: A Study from the European Liver Transplant Registry

Liver Cancer ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 455-467
Author(s):  
Hans-Christian Pommergaard ◽  
Andreas Arendtsen Rostved ◽  
René Adam ◽  
Mauro Salizzoni ◽  
Miguel Angel Gómez Bravo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Cirrhotic Liver ◽  
Unmeasured Confounding ◽  
Increased Risk ◽  
Specific Mortality ◽  
Transplant Registry ◽  
Cirrhotic Patients ◽  
Overall Mortality

Background and Aims: Prognosis after liver transplantation differs between hepatocellular carcinoma (HCC) arising in cirrhotic and non-cirrhotic livers and aetiology is poorly understood. The aim was to investigate differences in mortality after liver transplantation between these patients. Methods: We included patients from the European Liver Transplant Registry transplanted due to HCC from 1990 to November 2016 and compared cirrhotic and non-cirrhotic patients using propensity score (PS) calibration of Cox regression estimates to adjust for unmeasured confounding. Results: We included 22,787 patients, of whom 96.5% had cirrhosis. In the unadjusted analysis, non-cirrhotic patients had an increased risk of overall mortality with a hazard ratio (HR) of 1.37 (95% confidence interval [CI] 1.23–1.52). However, the HR approached unity with increasing adjustment and was 1.11 (95% CI 0.99–1.25) when adjusted for unmeasured confounding. Unadjusted, non-cirrhotic patients had an increased risk of HCC-specific mortality (HR 2.62, 95% CI 2.21–3.12). After adjustment for unmeasured confounding, the risk remained significantly increased (HR 1.62, 95% CI 1.31–2.00). Conclusions: Using PS calibration, we showed that HCC in non-cirrhotic liver has similar overall mortality, but higher HCC-specific mortality. This may be a result of a more aggressive cancer form in the non-cirrhotic liver as higher mortality could not be explained by tumour characteristics or other prognostic variables.

Liver Transplantation After Downstagings of Ruptured Advanced Hepatocellular Carcinoma in Cirrhotic Liver: Is It Advisable? A Case Report

2019 ◽  
Vol 51 (5) ◽  
pp. 1468-1471 ◽  
Author(s):  
Kuo-Shyang Jeng ◽  
Chun-Chieh Huang ◽  
Chien-Chu Lin ◽  
Cheng-Kuan Lin ◽  
Chung-Jen Teng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Case Report ◽  
Cirrhotic Liver ◽  
Advanced Hepatocellular Carcinoma

scholarly journals Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis

2018 ◽  
Vol 28 (4) ◽  
pp. 76-83
Author(s):  
O. D. Olisov ◽  
M. S. Novruzbekov ◽  
I. E. Galankina ◽  
L. N. Zimina ◽  
V. A. Gulyaev ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Cirrhosis ◽  
Normal Liver ◽  
Chronic Viral Hepatitis ◽  
Cirrhotic Liver ◽  
Control Group ◽  
Large Tumor ◽  
Unresectable Hepatocellular Carcinoma

Aim. The aim of the study is to determine the effectiveness of liver transplantation (LT) in the treatment of unresectable hepatocellular carcinoma (HCC) occurred in normal liver.Material and methods.  6 patients with unresectable HCC underwent orthotopic liver transplantation (OLT). The long-term OLT results were compared with survival results of liver resection in patients with late stage HCC.Results.  Hepatocellular carcinoma is one of the most common types of cancer, which occurs mainly in patients with liver cirrhosis and chronic viral hepatitis. Only about 10 % of HCC develops in non-cirrhotic liver among young and somatically healthy patients. 1-, 3-, 5-year recurrence-free and overall survival in LT group was significantly better than in the control group.Conclusion.  LT is indicated for patients with unresectable HCC in non-cirrhotic liver and its extrahepatic localization. A large tumor size and macrovascular invasion should not be a contraindication for LT in such patients. 

miR-203 expression predicts outcome after liver transplantation for hepatocellular carcinoma in cirrhotic liver

2011 ◽  
Vol 29 (3) ◽  
pp. 1859-1865 ◽  
Author(s):  
Hong-Yuan Chen ◽  
Zhong-Bo Han ◽  
Jun-Wei Fan ◽  
Jun Xia ◽  
Jun-Yi Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Cirrhotic Liver

Outcome of patients with recurrent hepatocellular carcinoma after liver transplantation

2010 ◽  
Vol 48 (05) ◽  
Author(s):  
A Finkenstedt ◽  
I Graziadei ◽  
H Zoller ◽  
K Nachbaur ◽  
W Mark ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Recurrent Hepatocellular Carcinoma

Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
G Wiltberger ◽  
U Lange ◽  
H Hau ◽  
D Seehofer ◽  
F Krenzien ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Coffee Consumption ◽  
Protective Effects
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