Donor citrate reactions influence the phenotype of apheresis platelets following storage

Transfusion ◽  
2021 ◽  
Author(s):  
Dianne E. Wal ◽  
April M. Davis ◽  
Denese C. Marks
Keyword(s):  
Apheresis Platelets

scholarly journals Refrigeration of apheresis platelets in platelet additive solution ( PAS‐E ) supports in vitro platelet quality to maximize the shelf‐life

Transfusion ◽  
2021 ◽  
Vol 61 (S1) ◽  
Author(s):  
Lacey Johnson ◽  
Shuchna Vekariya ◽  
Ben Wood ◽  
Shereen Tan ◽  
Christopher Roan ◽  
...  
Keyword(s):  
Shelf Life ◽  
Additive Solution ◽  
Apheresis Platelets

Effect of acetylsalicylic acid usage and platelet transfusion on postoperative hemorrhage and activities of daily living in patients with acute intracerebral hemorrhage

2013 ◽  
Vol 118 (1) ◽  
pp. 94-103 ◽  
Author(s):  
Xiaowei Li ◽  
Zhaosheng Sun ◽  
Wangmiao Zhao ◽  
Jinrong Zhang ◽  
Jianchao Chen ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Mortality Rate ◽  
Activities Of Daily Living ◽  
Acetylsalicylic Acid ◽  
Daily Living ◽  
Controlled Trial ◽  
Postoperative Hemorrhage ◽  
Basal Ganglia Hemorrhage ◽  
Hemorrhage Volume ◽  
Apheresis Platelets

Object The authors evaluated the effects of acetylsalicylic acid (ASA) usage and transfusion of previously frozen apheresis platelets on postoperative hemorrhage, activities of daily living (ADL) score, and mortality rate in patients with acute hypertensive basal ganglia hemorrhage undergoing craniotomy. Methods This was a prospective, double-blind, parallel, randomized controlled trial in patients with acute hypertensive basal ganglia hemorrhage, who had either not received ASA therapy (control) or received ASA therapy. The patients who received ASA therapy were divided according to the results of a platelet aggregation test into ASA-resistant, ASA-semiresponsive, and ASA-sensitive groups. All patients required an emergency craniotomy for hematoma removal after hospitalization. The patients who were sensitive to ASA were randomized to receive one of the following transfusion regimens of previously frozen apheresis platelets: no transfusion, 1 therapeutic dose before surgery, or 2 therapeutic doses (1 before surgery and 1 after 24 hours of hospitalization). The postoperative hemorrhage rate and the average postoperative hemorrhage volume were recorded and the ADL scores and mortality rate were measured during a 6-month follow-up period. Results The rate of postoperative hemorrhage, average postoperative hemorrhage volume, and mortality rate were significantly higher in the ASA-sensitive patients who received ASA therapy compared with patients who did not receive ASA therapy (all p < 0.005). The ADL scores were grouped into different grades and the number of cases in the lower grades was higher and the overall scores were poorer in patients who received ASA therapy compared with those who did not (all p < 0.005). After transfusion of previously frozen apheresis platelets, the postoperative hemorrhage rate, average postoperative hemorrhage volume, and mortality rate of the ASA-sensitive patients were significantly lowered (all p < 0.005), and the ADL scores and their classification level were better than those of patients who did not undergo transfusion (all p < 0.005). Conclusions Transfusion of previously frozen apheresis platelets reduces the rate of postoperative hemorrhage, average postoperative hemorrhage volume, disability rate, and mortality rate in ASA-sensitive patients with acute hypertensive basal ganglia hemorrhage undergoing craniotomy.

Evaluation of the Mirasol platelet reduction technology system against Babesia microti in apheresis platelets and plasma

Transfusion ◽  
2009 ◽  
Vol 50 (5) ◽  
pp. 1019-1027 ◽  
Author(s):  
Laura Tonnetti ◽  
Melanie C. Proctor ◽  
Heather L Reddy ◽  
Raymond P. Goodrich ◽  
David A. Leiby
Keyword(s):  
Babesia Microti ◽  
Technology System ◽  
Apheresis Platelets

scholarly journals Evaluation of bacterial inactivation in random donor platelets and single-donor apheresis platelets by the INTERCEPT blood system

2018 ◽  
Vol 12 (2) ◽  
pp. 146 ◽  
Author(s):  
RajNath Makroo ◽  
Raman Sardana ◽  
Leena Mediratta ◽  
Hena Butta ◽  
UdayKumar Thakur ◽  
...  
Keyword(s):  
Blood System ◽  
Bacterial Inactivation ◽  
Single Donor ◽  
Apheresis Platelets

Acute Hemolytic Transfusion Reaction Due to Pooled Platelets: A Rare but Serious Adverse Event

2020 ◽  
Author(s):  
Richard Gammon ◽  
Susan Cook ◽  
Anthony Trinkle ◽  
Korena Thomas ◽  
Kaaron Benson
Keyword(s):  
High Titer ◽  
Donor Number ◽  
Transfusion Reaction ◽  
Normal Range ◽  
Dark Urine ◽  
Hemolytic Transfusion Reaction ◽  
Group A ◽  
Relapsed Lymphoma ◽  
Blood And Urine Samples ◽  
Apheresis Platelets

Abstract A female patient aged 65 years with blood group A with relapsed lymphoma had thrombocytopenia; leukocyte-reduced group O prestorage pooled platelet concentrates (PPLTs) were transfused without adverse events. She was discharged home, but 1.5 hours later she returned with fever and dark urine. Hypotension and tachycardia developed; she was admitted to the intensive care unit. Post-transfusion blood and urine samples were obtained. Serial dilutions from 5 donor testing tubes and a simulated PLT pool were performed and read at immediate spin and IgG. Testing confirmed an acute hemolytic transfusion reaction (AHTR): elevated lactate dehydrogenase (996 U/L; normal range 135 U/L–225 U/L) and undetectable haptoglobin (&lt;10 mg/dL; normal range 30 mg/dL–200 mg/dL) levels. Urinalysis showed dark amber urine but no significant quantity of red blood cells. At 37ºC the simulated pool and donor number 5 had high-titer anti-A. As a precaution, the donor was permanently deferred. Research has shown that PLT-associated AHTR has occurred with apheresis platelets but is very rare with whole blood–derived PLTs.

Impact of different hold time before addition of platelet additive solution on the in vitro quality of apheresis platelets

Transfusion ◽  
2006 ◽  
Vol 46 (6) ◽  
pp. 942-948 ◽  
Author(s):  
Jurgen Ringwald ◽  
Benedikt Haager ◽  
Daniel Krex ◽  
Robert Zimmermann ◽  
Erwin Strasser ◽  
...  
Keyword(s):  
Hold Time ◽  
Additive Solution ◽  
Apheresis Platelets

Quantitation of coated platelet potential during collection, storage, and transfusion of apheresis platelets

Transfusion ◽  
2011 ◽  
Vol 51 (12) ◽  
pp. 2690-2694 ◽  
Author(s):  
Roseleen Charania ◽  
James Smith ◽  
Sara K. Vesely ◽  
George L. Dale ◽  
Jennifer Holter
Keyword(s):  
Apheresis Platelets
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