scholarly journals Refrigeration of apheresis platelets in platelet additive solution ( PAS‐E ) supports in vitro platelet quality to maximize the shelf‐life

Transfusion ◽  
2021 ◽  
Vol 61 (S1) ◽  
Author(s):  
Lacey Johnson ◽  
Shuchna Vekariya ◽  
Ben Wood ◽  
Shereen Tan ◽  
Christopher Roan ◽  
...  
Keyword(s):  
Shelf Life ◽  
Additive Solution ◽  
Apheresis Platelets

Impact of different hold time before addition of platelet additive solution on the in vitro quality of apheresis platelets

Transfusion ◽  
2006 ◽  
Vol 46 (6) ◽  
pp. 942-948 ◽  
Author(s):  
Jurgen Ringwald ◽  
Benedikt Haager ◽  
Daniel Krex ◽  
Robert Zimmermann ◽  
Erwin Strasser ◽  
...  
Keyword(s):  
Hold Time ◽  
Additive Solution ◽  
Apheresis Platelets

In vitro and in vivo evaluation of apheresis platelets stored for 5 days in 65% platelet additive solution/35% plasma

Transfusion ◽  
2010 ◽  
Vol 50 (11) ◽  
pp. 2376-2385 ◽  
Author(s):  
Ralph R. Vassallo ◽  
John W. Adamson ◽  
Jerome L. Gottschall ◽  
Edward L. Snyder ◽  
Wanda Lee ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Additive Solution ◽  
Apheresis Platelets

Effects of immediate or delayed addition of platelet additive solution on the in vitro quality of apheresis platelets

Transfusion ◽  
2011 ◽  
Vol 52 (6) ◽  
pp. 1237-1244 ◽  
Author(s):  
Juergen Ringwald ◽  
Susanne Tully ◽  
Christoph Geier ◽  
Barbara Hauck ◽  
Dominik Weiss ◽  
...  
Keyword(s):  
Additive Solution ◽  
Apheresis Platelets

scholarly journals Exploratory studies of extended storage of apheresis platelets in a platelet additive solution (PAS)

Blood ◽  
2014 ◽  
Vol 123 (2) ◽  
pp. 271-280 ◽  
Author(s):  
Sherrill J. Slichter ◽  
Jill Corson ◽  
Mary Kay Jones ◽  
Todd Christoffel ◽  
Esther Pellham ◽  
...  
Keyword(s):  
Collection Method ◽  
Platelet Storage ◽  
Key Points ◽  
Additive Solution ◽  
And Storage ◽  
Apheresis Platelets ◽  
Storage Solution

Key Points Extended apheresis platelet storage is dependent on the collection method, storage in a storage solution, and storage bag composition. The lifespan of the platelet is not intrinsic to the cell, and platelet viability is better maintained in vitro than in vivo.

In vitro and in vivo quality of leukoreduced apheresis platelets stored in a new platelet additive solution

Transfusion ◽  
2012 ◽  
Vol 53 (5) ◽  
pp. 972-980 ◽  
Author(s):  
Larry J. Dumont ◽  
Jose A. Cancelas ◽  
Sharon Graminske ◽  
Kenneth D. Friedman ◽  
Ralph R. Vassallo ◽  
...  
Keyword(s):  
Additive Solution ◽  
Apheresis Platelets

In vitro and in vivo application of active compounds with anti-yeast activity to improve the shelf life of ready-to-eat table grape

2013 ◽  
Vol 29 (6) ◽  
pp. 1075-1084 ◽  
Author(s):  
Costa Cristina ◽  
Lucera Annalisa ◽  
Conte Amalia ◽  
Contò Francesco ◽  
Matteo Alessandro Del Nobile
Keyword(s):  
Shelf Life ◽  
Table Grape ◽  
Active Compounds

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion

2021 ◽  
Vol 13 (604) ◽  
pp. eabb1069
Author(s):  
Yuping Fan ◽  
Yan Teng ◽  
Fabien Loison ◽  
Aiming Pang ◽  
Anongnard Kasorn ◽  
...  
Keyword(s):  
Cell Death ◽  
Shelf Life ◽  
Ex Vivo ◽  
Combined Treatment ◽  
Bacterial Killing ◽  
Immunodeficient Mice ◽  
Cell Death Pathways ◽  
Multiple Cell ◽  
Human And Mouse

Clinical outcomes from granulocyte transfusion (GTX) are disadvantaged by the short shelf life and compromised function of donor neutrophils. Spontaneous neutrophil death is heterogeneous and mediated by multiple pathways. Leveraging mechanistic knowledge and pharmacological screening, we identified a combined treatment, caspases–lysosomal membrane permeabilization–oxidant–necroptosis inhibition plus granulocyte colony-stimulating factor (CLON-G), which altered neutrophil fate by simultaneously targeting multiple cell death pathways. CLON-G prolonged human and mouse neutrophil half-life in vitro from less than 1 day to greater than 5 days. CLON-G–treated aged neutrophils had equivalent morphology and function to fresh neutrophils, with no impairment to critical effector functions including phagocytosis, bacterial killing, chemotaxis, and reactive oxygen species production. Transfusion with stored CLON-G–treated 3-day-old neutrophils enhanced host defenses, alleviated infection-induced tissue damage, and prolonged survival as effectively as transfusion with fresh neutrophils in a clinically relevant murine GTX model of neutropenia-related bacterial pneumonia and systemic candidiasis. Last, CLON-G treatment prolonged the shelf life and preserved the function of apheresis-collected human GTX products both ex vivo and in vivo in immunodeficient mice. Thus, CLON-G treatment represents an effective and applicable clinical procedure for the storage and application of neutrophils in transfusion medicine, providing a therapeutic strategy for improving GTX efficacy.

In vitro and in vivo effects of potassium and magnesium on storage up to 7 days of apheresis platelet concentrates in platelet additive solution

Vox Sanguinis ◽  
2007 ◽  
Vol 0 (0) ◽  
pp. 071127145052002-??? ◽  
Author(s):  
B. Diedrich ◽  
P. Sandgren ◽  
B. Jansson ◽  
H. Gulliksson ◽  
L. Svensson ◽  
...  
Keyword(s):  
Platelet Concentrates ◽  
Additive Solution ◽  
In Vivo Effects
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