scholarly journals A new definition for massive transfusion in the modern era of whole blood resuscitation

Transfusion ◽  
2021 ◽  
Vol 61 (S1) ◽  
Author(s):  
Parker Hu ◽  
Rindi Uhlich ◽  
Jonathan Black ◽  
Jan O. Jansen ◽  
Jeffrey Kerby ◽  
...  
Keyword(s):  
Whole Blood ◽  
Massive Transfusion ◽  
Modern Era

Use of unrefrigerated fresh whole blood in massive transfusion

1996 ◽  
Vol 165 (1) ◽  
pp. 11-13 ◽  
Author(s):  
Wendy N Erber ◽  
Joel Tan ◽  
Dianne Grey ◽  
John A G Lown
Keyword(s):  
Whole Blood ◽  
Massive Transfusion

Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Barbara A. Gaines ◽  
Mark H. Yazer ◽  
Darrell J. Triulzi ◽  
Jason L. Sperry ◽  
Matthew D. Neal ◽  
...  
Keyword(s):  
Whole Blood ◽  
Massive Transfusion ◽  
Titer Group

The Use of Fresh Whole Blood in Massive Transfusion

2006 ◽  
Vol 60 (Supplement) ◽  
pp. S59-S69 ◽  
Author(s):  
Thomas B. Repine ◽  
Jeremy G. Perkins ◽  
David S. Kauvar ◽  
Lorne Blackborne
Keyword(s):  
Whole Blood ◽  
Massive Transfusion

A comparison between leukocyte reduced low titer whole blood vs non‐leukocyte reduced low titer whole blood for massive transfusion activation

Transfusion ◽  
2020 ◽  
Vol 60 (12) ◽  
pp. 2834-2840
Author(s):  
Emmanuel A. Fadeyi ◽  
Amit K. Saha ◽  
Tawfeq Naal ◽  
Harrison Martin ◽  
Elena Fenu ◽  
...  
Keyword(s):  
Whole Blood ◽  
Massive Transfusion

scholarly journals Normalization of Blood Clotting Characteristics Using Prothrombin Complex Concentrate, Fibrinogen and Fxiii In an Albumin Based Fluid: Experimental Studies In Thromboelastometry.

2020 ◽  
Author(s):  
Tobias Koller ◽  
Nadia Kinast ◽  
Andres Guilarte Castellanos ◽  
Sergio Perez Garcia ◽  
Pilar Paniagua Iglesias ◽  
...  
Keyword(s):  
Whole Blood ◽  
Factor Xiii ◽  
Prothrombin Complex Concentrate ◽  
Massive Transfusion ◽  
Experimental Studies ◽  
Coagulation Factor ◽  
Fibrin Clot ◽  
Fibrinogen Concentrate ◽  
Coagulation Factor Concentrates

Abstract Background: Colloid fluids supplemented with adequate combinations of coagulation factor concentrates with capability to restore coagulation could be a desirable future treatment component in massive transfusion.Methods: Starting from a coagulation factor and blood cell free albumin solution we added Prothrombin Complex Concentrate, Fibrinogen Concentrate and Factor XIII in different combinations and concentrations to analyze their properties to restore thromboelastometry parameters without the use of plasma. Further analysis under presence of platelets was performed for comparability to whole blood conditions.Results: Albumin solutions enriched with Fibrinogen Concentrate, Factor XIII and Prothrombin Complex Concentrate at optimized concentrations show restoring coagulation potential. Prothrombin Complex Concentrate showed sufficient thrombin formation for inducing fibrinogen polymerization. The combination of Prothrombin Complex Concentrate and Fibrinogen Concentrate led to the formation of a stable in vitro fibrin clot. Fibrinogen and Factor XIII showed excellent capacity to improve fibrin clot firmness expressed as Amplitude at 10 minutes and Maximal Clot Firmness. Fibrinogen alone, or in combination with Factor XIII, was able to restore normal Amplitude at 10 minutes and Maximal Clot Firmness values. In the presence of platelets, the thromboelastometry surrogate parameter for thrombin generation (Clotting Time) improves and normalizes when compared to whole blood.Conclusions: Combinations of coagulation factor concentrates suspended in albumin solutions have the capacity to restore thromboelastometry parameters in the absence of plasma. This kind of artificial colloid fluids with coagulation-restoring characteristics might offer new treatment alternatives for massive transfusion.Trial registration: Study registered at the institutional ethic committee “Institut de Recerca, Hospital Santa Creu i Sant Pau, with protocol number IIBSP-CFC-2013-165.

scholarly journals Normalization Of Blood Clotting Characteristics Using Prothrombin Complex Concentrate, Fibrinogen And FXIII In An Albumin Based Fluid: Experimental Studies In Thromboelastometry.

2021 ◽  
Author(s):  
Tobias Koller ◽  
Nadia Kinast ◽  
Andres Guilarte Castellanos ◽  
Sergio Perez Garcia ◽  
Pilar Paniagua Iglesias ◽  
...  
Keyword(s):  
Whole Blood ◽  
Factor Xiii ◽  
Prothrombin Complex Concentrate ◽  
Massive Transfusion ◽  
Experimental Studies ◽  
Coagulation Factor ◽  
Fibrin Clot ◽  
Fibrinogen Concentrate ◽  
Coagulation Factor Concentrates

Abstract Background: Colloid fluids supplemented with adequate combinations of coagulation factor concentrates with the capability to restore coagulation could be a desirable future treatment component in massive transfusion.Methods: Starting from a coagulation factor and blood cell-free albumin solution we added Prothrombin Complex Concentrate, Fibrinogen Concentrate and Factor XIII in different combinations and concentrations to analyze their properties to restore thromboelastometry parameters without the use of plasma. Further analysis under the presence of platelets was performed for comparability to whole blood conditions.Results: Albumin solutions enriched with Fibrinogen Concentrate, Factor XIII and Prothrombin Complex Concentrate at optimized concentrations show restoring coagulation potential. Prothrombin Complex Concentrate showed sufficient thrombin formation for inducing fibrinogen polymerization. The combination of Prothrombin Complex Concentrate and Fibrinogen Concentrate led to the formation of a stable in vitro fibrin clot. Fibrinogen and Factor XIII showed excellent capacity to improve fibrin clot firmness expressed as Amplitude at 10 minutes and Maximal Clot Firmness. Fibrinogen alone, or in combination with Factor XIII, was able to restore normal Amplitude at 10 minutes and Maximal Clot Firmness values. In the presence of platelets, the thromboelastometry surrogate parameter for thrombin generation (Clotting Time) improves and normalizes when compared to whole blood.Conclusions: Combinations of coagulation factor concentrates suspended in albumin solutions can restore thromboelastometry parameters in the absence of plasma. This kind of artificial colloid fluids with coagulation-restoring characteristics might offer new treatment alternatives for massive transfusion.Trial registration: Study registered at the institutional ethic committee “Institut de Recerca, Hospital Santa Creu i Sant Pau, with protocol number IIBSP-CFC-2013-165.

Use of unrefrigerated fresh whole blood in massive transfusion

1996 ◽  
Vol 165 (9) ◽  
pp. 525-526
Author(s):  
Alison IUI Street ◽  
Merrole F Cole‐Sinclair
Keyword(s):  
Whole Blood ◽  
Massive Transfusion

Massive transfusion of low-titer cold-stored O-positive whole blood in a civilian trauma setting

Transfusion ◽  
2018 ◽  
Vol 59 (3) ◽  
pp. 927-930 ◽  
Author(s):  
Mary Condron ◽  
Mick Scanlan ◽  
Martin Schreiber
Keyword(s):  
Whole Blood ◽  
Massive Transfusion ◽  
Civilian Trauma
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