Massive transfusion of low-titer cold-stored O-positive whole blood in a civilian trauma setting

Transfusion ◽  
2018 ◽  
Vol 59 (3) ◽  
pp. 927-930 ◽  
Author(s):  
Mary Condron ◽  
Mick Scanlan ◽  
Martin Schreiber
Keyword(s):  
Whole Blood ◽  
Massive Transfusion ◽  
Civilian Trauma

Whole Blood Versus Conventional Blood Component Massive Transfusion Protocol Therapy in Civilian Trauma Patients

2021 ◽  
pp. 000313482110497
Author(s):  
Janet S. Lee ◽  
Abid D. Khan ◽  
Franklin L. Wright ◽  
Robert C. McIntyre ◽  
Warren C. Dorlac ◽  
...  
Keyword(s):  
Whole Blood ◽  
Injury Severity ◽  
Massive Transfusion ◽  
Blood Component ◽  
Trauma Patients ◽  
Massive Transfusion Protocol ◽  
Civilian Trauma ◽  
Transfusion Volume ◽  
Blood Component Therapy ◽  
Transfusion Protocol

Background Military data demonstrating an improved survival rate with whole blood (WB) have led to a shift toward the use of WB in civilian trauma. The purpose of this study is to compare a low-titer group O WB (LTOWB) massive transfusion protocol (MTP) to conventional blood component therapy (BCT) MTP in civilian trauma patients. Methods Trauma patients 15 years or older who had MTP activations from February 2019 to December 2020 were included. Patients with a LTOWB MTP activation were compared to BCT MTP patients from a historic cohort. Results 299 patients were identified, 169 received LTOWB and 130 received BCT. There were no differences in age, gender, or injury type. The Injury Severity Score was higher in the BCT group (27 vs 25, P = .006). The LTOWB group had a longer transport time (33 min vs 26 min, P < .001) and a lower arrival temperature (35.8 vs 36.1, P < .001). Other hemodynamic parameters were similar between the groups. The LTOWB group had a lower in-hospital mortality rate compared to the BCT group (19.5% vs 30.0%, P = .035). There were no differences in total transfusion volumes at 4 hours and 24 hours. No differences were seen in transfusion reactions or hospital complications. Multivariable logistic regression identified ISS, age, and 24-hour transfusion volume as predictors of mortality. Discussion Resuscitating severely injured trauma patient with LTOWB is safe and may be associated with an improved survival.

Use of unrefrigerated fresh whole blood in massive transfusion

1996 ◽  
Vol 165 (1) ◽  
pp. 11-13 ◽  
Author(s):  
Wendy N Erber ◽  
Joel Tan ◽  
Dianne Grey ◽  
John A G Lown
Keyword(s):  
Whole Blood ◽  
Massive Transfusion

scholarly journals A new definition for massive transfusion in the modern era of whole blood resuscitation

Transfusion ◽  
2021 ◽  
Vol 61 (S1) ◽  
Author(s):  
Parker Hu ◽  
Rindi Uhlich ◽  
Jonathan Black ◽  
Jan O. Jansen ◽  
Jeffrey Kerby ◽  
...  
Keyword(s):  
Whole Blood ◽  
Massive Transfusion ◽  
Modern Era

Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Barbara A. Gaines ◽  
Mark H. Yazer ◽  
Darrell J. Triulzi ◽  
Jason L. Sperry ◽  
Matthew D. Neal ◽  
...  
Keyword(s):  
Whole Blood ◽  
Massive Transfusion ◽  
Titer Group

The Use of Fresh Whole Blood in Massive Transfusion

2006 ◽  
Vol 60 (Supplement) ◽  
pp. S59-S69 ◽  
Author(s):  
Thomas B. Repine ◽  
Jeremy G. Perkins ◽  
David S. Kauvar ◽  
Lorne Blackborne
Keyword(s):  
Whole Blood ◽  
Massive Transfusion

The use of low-titer group O whole blood for the resuscitation of civilian trauma patients in 2018

Transfusion ◽  
2018 ◽  
Vol 58 (11) ◽  
pp. 2744-2746 ◽  
Author(s):  
Mark H. Yazer ◽  
Philip C. Spinella
Keyword(s):  
Whole Blood ◽  
Trauma Patients ◽  
Civilian Trauma ◽  
Titer Group

A comparison between leukocyte reduced low titer whole blood vs non‐leukocyte reduced low titer whole blood for massive transfusion activation

Transfusion ◽  
2020 ◽  
Vol 60 (12) ◽  
pp. 2834-2840
Author(s):  
Emmanuel A. Fadeyi ◽  
Amit K. Saha ◽  
Tawfeq Naal ◽  
Harrison Martin ◽  
Elena Fenu ◽  
...  
Keyword(s):  
Whole Blood ◽  
Massive Transfusion

Whole blood for the acutely haemorrhaging civilian trauma patient: a novel idea or rediscovery?

2016 ◽  
Vol 26 (6) ◽  
pp. 406-414 ◽  
Author(s):  
M. P. Bahr ◽  
M. H. Yazer ◽  
D. J. Triulzi ◽  
R. A. Collins
Keyword(s):  
Trauma Patient ◽  
Whole Blood ◽  
Civilian Trauma

scholarly journals Normalization of Blood Clotting Characteristics Using Prothrombin Complex Concentrate, Fibrinogen and Fxiii In an Albumin Based Fluid: Experimental Studies In Thromboelastometry.

2020 ◽  
Author(s):  
Tobias Koller ◽  
Nadia Kinast ◽  
Andres Guilarte Castellanos ◽  
Sergio Perez Garcia ◽  
Pilar Paniagua Iglesias ◽  
...  
Keyword(s):  
Whole Blood ◽  
Factor Xiii ◽  
Prothrombin Complex Concentrate ◽  
Massive Transfusion ◽  
Experimental Studies ◽  
Coagulation Factor ◽  
Fibrin Clot ◽  
Fibrinogen Concentrate ◽  
Coagulation Factor Concentrates

Abstract Background: Colloid fluids supplemented with adequate combinations of coagulation factor concentrates with capability to restore coagulation could be a desirable future treatment component in massive transfusion.Methods: Starting from a coagulation factor and blood cell free albumin solution we added Prothrombin Complex Concentrate, Fibrinogen Concentrate and Factor XIII in different combinations and concentrations to analyze their properties to restore thromboelastometry parameters without the use of plasma. Further analysis under presence of platelets was performed for comparability to whole blood conditions.Results: Albumin solutions enriched with Fibrinogen Concentrate, Factor XIII and Prothrombin Complex Concentrate at optimized concentrations show restoring coagulation potential. Prothrombin Complex Concentrate showed sufficient thrombin formation for inducing fibrinogen polymerization. The combination of Prothrombin Complex Concentrate and Fibrinogen Concentrate led to the formation of a stable in vitro fibrin clot. Fibrinogen and Factor XIII showed excellent capacity to improve fibrin clot firmness expressed as Amplitude at 10 minutes and Maximal Clot Firmness. Fibrinogen alone, or in combination with Factor XIII, was able to restore normal Amplitude at 10 minutes and Maximal Clot Firmness values. In the presence of platelets, the thromboelastometry surrogate parameter for thrombin generation (Clotting Time) improves and normalizes when compared to whole blood.Conclusions: Combinations of coagulation factor concentrates suspended in albumin solutions have the capacity to restore thromboelastometry parameters in the absence of plasma. This kind of artificial colloid fluids with coagulation-restoring characteristics might offer new treatment alternatives for massive transfusion.Trial registration: Study registered at the institutional ethic committee “Institut de Recerca, Hospital Santa Creu i Sant Pau, with protocol number IIBSP-CFC-2013-165.

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