scholarly journals Severe iron deficiency anemia: red blood cell transfusion or intravenous iron?

Transfusion ◽  
2018 ◽  
Vol 58 (8) ◽  
pp. 1824-1826 ◽  
Author(s):  
Christian P. Nixon ◽  
Joseph D. Sweeney
2012 ◽  
Vol 34 (3) ◽  
pp. e125-e126 ◽  
Author(s):  
Mouhammad Rateb Alwazeer ◽  
Hamayun Imran ◽  
Felicia M. Wilson ◽  
Abdul Hafeez Siddiqui

Transfusion ◽  
2018 ◽  
Vol 58 (6) ◽  
pp. 1399-1407
Author(s):  
Miguel Angel de las Nieves Lopez ◽  
Ana Maria Matas Cobos ◽  
Francisco Sarria Gonzalez ◽  
Maria Jose Dominguez Lomeña ◽  
Ana Maria Palomo Hernandez ◽  
...  

2019 ◽  
Vol 13 (2) ◽  
pp. 026007
Author(s):  
Mei-qing Lei ◽  
Ling-feng Sun ◽  
Xian-sheng Luo ◽  
Xiao-yang Yang ◽  
Feng Yu ◽  
...  

2012 ◽  
Vol 7 (1) ◽  
pp. 168 ◽  
Author(s):  
Esam G Abdelrahman ◽  
Gasim I Gasim ◽  
Imad R Musa ◽  
Leana M Elbashir ◽  
Ishag Adam

Hematology ◽  
2008 ◽  
Vol 13 (4) ◽  
pp. 253-256 ◽  
Author(s):  
J. Eivazi-Ziaei ◽  
S. Dastgiri ◽  
S. Pourebrahim ◽  
R. Soltanpour

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 4559-4559
Author(s):  
Ahmad Jajeh

Abstract Background: Iron metabolism is impaired in patients with cancer and actively receiving chemotherapy. Patients with cancer on active chemotherapy suffer with decreased appetite , poor nutrition, mucositis, gastrointestinal mucosal damage, blood loss as well as anemia of chronic disease due to cytokines release such as Tumor Necrosis Factor, Interleukins and histamins. The purpose of this abstract is to show single institution experience with patients actively receiving chemotherapy and admitted for various reasons and found to have anemia and particularly those patients that were admitted for red blood cell transfusion. Retrospective review of three hundred and fifty patients admitted in the last two years 2014-2015 for different reasons while on chemotherapy with anemia or mainly for blood transfusion. 55% females and 45% males. 77% had solid tumors and 23% with hematological malignancies. Median age 70 years. Thirty five percent 35% of solid tumors were of GI malignancies. Seventy five percenct of all patients had low iron saturation, low serum iron with normal to high total Iron Binding Capacity TIBC. Ferritin level was low in 60% of the patients. Ferritin is a phase reactive markers was elevated in 40% of patients. All patients with elevated ferritin were having low iron saturation with low serum iron and low or normal TIBC. Sixty five 65% of patients received blood transfusion. All patients with iron deficency received intravenous elemental iron support to saturate iron stores. In conclusion: Iron deficiency anemia is very common in patient on active chemotherapy. With Intravenous elemental iron supplemet the requirement of less future red blood transfusion and improvement of hemoglobin levels were achieved in most of patients responding to chemotherapy. Need prospective analysis on patients diagnosed with malignancies and start receiving chemotherapy to prove the value of IV iron support and less requirement of red blood cell transfusion. Disclosures No relevant conflicts of interest to declare.


2019 ◽  
Vol 16 (32) ◽  
pp. 471-477
Author(s):  
Leila I. ARYSTAN ◽  
Gulmira M. MULDAEVA ◽  
Leila S. HAYDARGALIEVA ◽  
Damira K. PAKHOMOVA ◽  
Yernar B. ISKAKOV

The problem of iron deficiency is urgent in many countries, regardless of the socio-economic standards of living. Among biomedical problems, the study of biochemical blood parameters is of paramount importance. A great interest in various aspects of this issue is not accidental, since the transport function of the blood largely depends on it and, consequently, the efficient delivery of oxygen, glucose, amino acids, fats, vitamins, mineral salts, hormones, mediators, antibodies and metabolites to the micro-zones in the tissues. The purpose of this article is to study the hematological status and the state of the red blood cell membrane in women of reproductive age suffering from iron deficiency anemia (IDA). Iron deficiency anemia (IDA) is a combination of clinical and hematological symptoms characterized by impaired hemoglobin formation due to iron deficiency in serum and bone marrow, as well as the development of trophic disorders in the organs and tissues. During the study, a complete blood count was performed using an enzyme-linked immunosorbent assay, using the kits produced by JSC Vector-Best, and the Kamyshnikov method. Based on the results of the study of the erythrocyte sorption capacity (ESC) in women of reproductive age with IDA, it was established that this parameter is 1.2 times higher than that in the control group. The development of anemia is associated with significant changes in the osmotic stability of the erythrocytes, which results in an increase in the proportion of both unstable and high-resistance erythrocytes. The scientific novelty of the article is that the authors established the key parameters for iron deficiency anemia detection.


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