Red blood cell transfusion after a global strategy for early detection and treatment of iron deficiency anemia: three-year results of a prospective observational study

Transfusion ◽  
2018 ◽  
Vol 58 (6) ◽  
pp. 1399-1407
Author(s):  
Miguel Angel de las Nieves Lopez ◽  
Ana Maria Matas Cobos ◽  
Francisco Sarria Gonzalez ◽  
Maria Jose Dominguez Lomeña ◽  
Ana Maria Palomo Hernandez ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Early Detection ◽  
Observational Study ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Prospective Observational Study ◽  
Global Strategy ◽  
Red Blood Cell Transfusion ◽  
Deficiency Anemia

Pancytopenia After Packed Red Blood Cell Transfusion for Severe Iron Deficiency Anemia in a Toddler

2012 ◽  
Vol 34 (3) ◽  
pp. e125-e126 ◽  
Author(s):  
Mouhammad Rateb Alwazeer ◽  
Hamayun Imran ◽  
Felicia M. Wilson ◽  
Abdul Hafeez Siddiqui
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion ◽  
Deficiency Anemia

MO557EFFICIENCY OF FERRIC CARBOXYMALTOSE IN NON-DIALYSIS CKD PATIENTS AND ITS IMPACT ON KIDNEY FUNCTION: A PROSPECTIVE OBSERVATIONAL STUDY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Marisa Roldão ◽  
Rachele Escoli ◽  
Hernâni Gonçalves ◽  
Karina Lopes
Keyword(s):  
Iron Deficiency ◽  
Observational Study ◽  
Kidney Function ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Prospective Observational Study ◽  
Pearson Correlation ◽  
Deficiency Anemia ◽  
Ferric Carboxymaltose ◽  
Ckd Stage

Abstract Background and Aims Iron deficiency anemia occurs in the vast majority of patients with chronic kidney disease (CKD). The aim of this study was to investigate the efficacy of ferric carboxymaltose (FCM) iron deficiency anemia’s treatment in non-dialysis CKD patients and to clarify its impact on kidney function. Method Prospective observational study of non-dialysis CKD stage 3 to 5 patients, with anemia and iron deficiency treated with FCM from 01 January 2019 to 31 June 2020. FCM was administrated as a single IV infusion of 500mg or 1000mg. Baseline clinical, analytical and demographic data were recorded. FCM efficacy was evaluated by comparing hemoglobin (Hb), serum ferritin and transferrin saturation index (TSAT) 24 ± 8 weeks after the infusion with analytical values at baseline. Renal function was also assessed at baseline and at 24 ± 8 weeks using estimated glomerular filtration rate (eGFR), calculated by CKD-EPI formula. Statistical analysis was executed using SPSS (Version 23 for Mac OSX). Results The average age of 71 patients was 77.31 ± 9.68 years, 29 (40.8%) were male, 46 (64.8%) were diabetic and 41 (57.8%) had congestive heart failure. Sixteen (22.5%) patients had CKD stage 3, 41 (57.7%) stage 4 and 14 (19.7%) stage 5. Twenty-five (35.2%) patients were treated with 1000mg of FCM. At baseline, average hemoglobin level (Hb) was 10.16 ± 1.12g/dL, serum ferritin 83.25 ± 96.55µg/L, TSAT 14.48 ± 6.72mg/dL and eGFR 24.21± 13.09ml/min/1.73m2. At 24 ± 8 weeks, Hb showed an increase of 1.31 ± 1.49 g/dL (p=0.001) and TSAT 10.68 ± 10.40% (p=0.001). Serum ferritin showed also an increase of 4.75 ± 180.53µg/L but did not reach statistical significance. The increase in Hb was observed uniformly across all stages of CKD. A Pearson correlation revealed a positive correlation between the variation of Hb and eGFR during the study follow-up period (r=0.310, p=0.008). A subgroup analysis was performed, patients were classified in 2 groups according to FCM dose. At baseline, there was no age, comorbidities or eGFR difference among groups. Patients treated with 1000mg had lower Hb (p=0.03) and serum ferritin (p=0.01). At 24±8 weeks both groups showed increases in Hb (p=0.001) and TSAT (p=0.001). Patients treated with 1000mg showed also a significant increase in ferritin (p=0.004). The Pearson correlation confirmed a positive correlation between the variation of Hb and eGFR in the group of patients treated with 1000mg (r=0.467, p=0.019) but not in the group treated with 500mg. Conclusion FCM was effective in the treatment of iron deficiency anemia in non-dialysis CKD stage 3 to 5 patients. In our population, the increase of Hb levels correlated with an improvement in eGFR in patients treated with higher doses of FCM, suggesting a positive impact of FCM on kidney function.

Distinguishing iron deficiency anemia from thalassemia by the red blood cell lifespan with a simple CO breath test: a pilot study

2019 ◽  
Vol 13 (2) ◽  
pp. 026007
Author(s):  
Mei-qing Lei ◽  
Ling-feng Sun ◽  
Xian-sheng Luo ◽  
Xiao-yang Yang ◽  
Feng Yu ◽  
...  
Keyword(s):  
Pilot Study ◽  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Breath Test ◽  
Deficiency Anemia ◽  
Cell Lifespan

Red blood cell transfusion and immune function in critically ill children: a prospective observational study

Transfusion ◽  
2014 ◽  
Vol 55 (4) ◽  
pp. 766-774 ◽  
Author(s):  
Jennifer A. Muszynski ◽  
Elfaridah Frazier ◽  
Ryan Nofziger ◽  
Jyotsna Nateri ◽  
Lisa Hanson-Huber ◽  
...  
Keyword(s):  
Observational Study ◽  
Blood Cell ◽  
Immune Function ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Prospective Observational Study ◽  
Red Blood Cell Transfusion ◽  
Critically Ill Children

scholarly journals Red blood cell distribution width and iron deficiency anemia among pregnant Sudanese women

2012 ◽  
Vol 7 (1) ◽  
pp. 168 ◽  
Author(s):  
Esam G Abdelrahman ◽  
Gasim I Gasim ◽  
Imad R Musa ◽  
Leana M Elbashir ◽  
Ishag Adam
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Iron Deficiency Anemia ◽  
Red Blood Cell ◽  
Deficiency Anemia ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution
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