Accumulation of oxidized peroxiredoxin 2 in red blood cells and its prevention

Transfusion ◽  
2015 ◽  
Vol 55 (8) ◽  
pp. 1909-1918 ◽  
Author(s):  
Simone B. Bayer ◽  
Mark B. Hampton ◽  
Christine C. Winterbourn
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Peroxiredoxin 2

scholarly journals Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements

Transfusion ◽  
2015 ◽  
Vol 55 (12) ◽  
pp. 2967-2978 ◽  
Author(s):  
Joo-Yeun Oh ◽  
Ryan Stapley ◽  
Victoria Harper ◽  
Marisa B. Marques ◽  
Rakesh P. Patel
Keyword(s):  
Red Blood Cells ◽  
Oxidation Kinetics ◽  
Blood Cells ◽  
Nitrite Oxidation ◽  
Peroxiredoxin 2 ◽  
Free Heme

Structural and functional analysis of native peroxiredoxin 2 in human red blood cells

2012 ◽  
Vol 44 (7) ◽  
pp. 1072-1077 ◽  
Author(s):  
Yuki Ogasawara ◽  
Takuya Ohminato ◽  
Yusuke Nakamura ◽  
Kazuyuki Ishii
Keyword(s):  
Functional Analysis ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Peroxiredoxin 2 ◽  
Human Red Blood Cells

Peroxiredoxin-2 as a candidate biomarker to test oxidative stress levels of stored red blood cells under blood bank conditions

Transfusion ◽  
2011 ◽  
Vol 51 (7) ◽  
pp. 1439-1449 ◽  
Author(s):  
Sara Rinalducci ◽  
Gian M. D'Amici ◽  
Barbara Blasi ◽  
Stefania Vaglio ◽  
Giuliano Grazzini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Blood Bank ◽  
Peroxiredoxin 2 ◽  
Stress Levels

scholarly journals Irreversible hyperoxidation of peroxiredoxin 2 is caused by tert- butyl hydroperoxide in human red blood cells

FEBS Open Bio ◽  
2014 ◽  
Vol 4 (1) ◽  
pp. 848-852 ◽  
Author(s):  
Y.I. Ishida ◽  
M. Takikawa ◽  
T. Suzuki ◽  
M. Nagahama ◽  
Y. Ogasawara
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Peroxiredoxin 2 ◽  
Human Red Blood Cells ◽  
Tert Butyl Hydroperoxide

Differential oxidation processes of peroxiredoxin 2 dependent on the reaction with several peroxides in human red blood cells

2019 ◽  
Vol 518 (4) ◽  
pp. 685-690
Author(s):  
Yo-ichi Ishida ◽  
Yuko Ichinowatari ◽  
Shoichi Nishimoto ◽  
Shin Koike ◽  
Kazuyuki Ishii ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Oxidation Processes ◽  
Peroxiredoxin 2 ◽  
Human Red Blood Cells

Hemoglobin crystals of the red blood cells in the human renal cortex: electron microscopic observations of the renal lithiasis

1978 ◽  
Vol 36 (2) ◽  
pp. 480-481
Author(s):  
Kosuke Ueda ◽  
Hiroto Washida ◽  
Nakazo Watari
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Renal Cortex ◽  
Uranyl Acetate ◽  
Osmic Acid ◽  
Renal Lithiasis ◽  
Electron Microscopic ◽  
Hemoglobin C ◽  
First Case ◽  
Ultrathin Sections

IntroductionHemoglobin crystals in the red blood cells were electronmicroscopically reported by Fawcett in the cat myocardium. In the human, Lessin revealed crystal-containing cells in the periphral blood of hemoglobin C disease patients. We found the hemoglobin crystals and its agglutination in the erythrocytes in the renal cortex of the human renal lithiasis, and these patients had no hematological abnormalities or other diseases out of the renal lithiasis. Hemoglobin crystals in the human erythrocytes were confirmed to be the first case in the kidney.Material and MethodsTen cases of the human renal biopsies were performed on the operations of the seven pyelolithotomies and three ureterolithotomies. The each specimens were primarily fixed in cacodylate buffered 3. 0% glutaraldehyde and post fixed in osmic acid, dehydrated in graded concentrations of ethanol, and then embedded in Epon 812. Ultrathin sections, cut on LKB microtome, were doubly stained with uranyl acetate and lead citrate.

Densitometric Identification of Primitive Erythroblasts After Reaction With Diaminobenzidine

1973 ◽  
Vol 31 ◽  
pp. 328-329
Author(s):  
John A. Trotter
Keyword(s):  
Red Blood Cells ◽  
Analytical Method ◽  
Blood Cells ◽  
Guinea Pigs ◽  
Specific Protein ◽  
Visual Examination ◽  
Hemoglobin Synthesis ◽  
Peroxidatic Activity ◽  
Small Density

Hemoglobin is the specific protein of red blood cells. Those cells in which hemoglobin synthesis is initiated are the earliest cells that can presently be considered to be committed to erythropoiesis. In order to identify such early cells electron microscopically, we have made use of the peroxidatic activity of hemoglobin by reacting the marrow of erythropoietically stimulated guinea pigs with diaminobenzidine (DAB). The reaction product appeared as a diffuse and amorphous electron opacity throughout the cytoplasm of reactive cells. The detection of small density increases of such a diffuse nature required an analytical method more sensitive and reliable than the visual examination of micrographs. A procedure was therefore devised for the evaluation of micrographs (negatives) with a densitometer (Weston Photographic Analyzer).

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