scholarly journals Restless legs syndrome, pica, and iron status in blood donors

Transfusion ◽  
2013 ◽  
Vol 53 (8) ◽  
pp. 1645-1652 ◽  
Author(s):  
Bryan R. Spencer ◽  
Steven Kleinman ◽  
David J. Wright ◽  
Simone A. Glynn ◽  
David B. Rye ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Blood Donors ◽  
Iron Status ◽  
Restless Legs

Restless legs syndrome in blood donors

2004 ◽  
Vol 5 (2) ◽  
pp. 115-118 ◽  
Author(s):  
Jan Ulfberg ◽  
Birgitta Nyström
Keyword(s):  
Restless Legs Syndrome ◽  
Blood Donors ◽  
Restless Legs

Ascertainment of Iron Depletion and Deficiency in Blood Donors Through Screening Questions for Pica and Restless Legs Syndrome.

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 2283-2283
Author(s):  
Barbara J. Bryant ◽  
Yu Ying Yau ◽  
Sarah M. Arceo ◽  
Julie A. Hopkins ◽  
Susan F. Leitman
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Blood Donors ◽  
Oral Iron ◽  
Iron Therapy ◽  
Iron Depletion ◽  
Restless Legs ◽  
Iron Deficient ◽  
Screening Questions ◽  
Iron Replacement

Abstract Abstract 2283 Background: Pica and restless legs syndrome (RLS) are associated with iron depletion and deficiency. Pica refers to the compulsive craving for and persistent consumption of non-nutritive substances. Pagophagia, the pathological consumption of ice, is a specific pica strongly associated with iron deficiency. RLS is a neurological movement disorder characterized by uncomfortable sensations in the lower extremities, with a compelling urge to move the extremities to relieve the discomfort. Primary RLS is a central nervous system disorder; however, secondary RLS may be caused or exacerbated by iron deficiency. The purpose of this study was to prospectively assess the prevalence of pica and RLS in blood donors presenting to a hospital-based donor center, to correlate the findings with donor hemoglobin and iron levels, and to study the effects of oral iron replacement on the resolution of symptoms. Methods: During a 39-month period, 1236 blood donors deferred for fingerstick hemoglobin <12.5 g/dL and 400 non-deferred “control” donors underwent health screening and laboratory testing (CBC, ferritin, iron, transferrin). Iron deficiency was defined as a ferritin level below the institutional reference range of 9 mcg/L in females and 18 mcg/L in males. Iron depletion was defined as a ferritin of 9 – 19 mcg/L in females and 18 – 29 mcg/L in males. Pica and RLS were assessed by direct questioning. Deferred donors and iron-deficient control donors were given ferrous sulfate 325 mg daily for 60 days. Reassessments were performed and additional iron tablets dispensed at subsequent visits. Results: Pica was reported in 11% of donors with iron depletion/deficiency, compared with 4% of iron-replete donors (p<0.0001). The prevalence of pica rose to 21% in females with ferritin <9 mcg/L. Pagophagia (ice pica) was most common and was often of extraordinary intensity, with characteristics of an addiction. Donors with pagophagia given iron reported a marked reduction in the desire to eat ice by day 5–8 of therapy, with disappearance of symptoms by day 10–14. RLS was reported in 16% of subjects with iron depletion/deficiency compared with 11% of iron-replete donors (p=0.012). Iron replacement generally resulted in improvement of RLS symptoms, however, at least 4–6 weeks of iron therapy was necessary. The positive predictive values of pica and RLS in iron deficient/depleted blood donors were 73% and 58%, respectively. Conclusion: The presence of pica is highly predictive of iron depletion/deficiency in blood donors; however, RLS lacks a strong correlation in this population. Screening questions for pica, in particular pagophagia, may be useful in the ascertainment of iron depletion and deficiency in blood donors and may identify those who would benefit from oral iron therapy. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Prevalence of restless legs syndrome in female blood donors 1 week after blood donation

Vox Sanguinis ◽  
2013 ◽  
Vol 107 (1) ◽  
pp. 44-49 ◽  
Author(s):  
B. Pedrazzini ◽  
S. Waldvogel ◽  
P. Vaucher ◽  
J. Cornuz ◽  
R. Heinzer ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Blood Donors ◽  
Blood Donation ◽  
Restless Legs

scholarly journals The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1313
Author(s):  
Susanne Macher ◽  
Cornelia Herster ◽  
Magdalena Holter ◽  
Martina Moritz ◽  
Eva Maria Matzhold ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Iron Supplementation ◽  
Blood Donors ◽  
Secondary Analysis ◽  
Chronic Fatigue ◽  
Oral Iron ◽  
Restless Legs ◽  
Fatigue Syndrome ◽  
Iron Deficient

Background: Besides anemia, iron deficiency may cause more subtle symptoms, including the restless legs syndrome (RLS), the chronic fatigue syndrome (CFS) or sleeping disorders. Objective: The aim of this pre-planned secondary analysis of the IronWoMan randomized controlled trial (RCT) was to compare the frequency and severity of symptoms associated with iron deficiency before and after (intravenous or oral) iron supplementation in iron deficient blood donors. Methods/Design: Prospective, randomized, controlled, single-centre trial. (ClinicalTrials.gov: NCT01787526). Setting: Tertiary care center in Graz, Austria. Participants: 176 (138 female and 38 male) whole-blood and platelet apheresis donors aged ≥ 18 and ≤ 65 years with iron deficiency (ferritin ≤ 30ng/mL at the time of blood donation). Interventions: Intravenous iron (1 g ferric carboxymaltose, n = 86) or oral iron supplementation (10 g iron fumarate, 100 capsules, n = 90). Measurements: Clinical symptoms were evaluated by a survey before iron therapy (visit 0, V0) and after 8–12 weeks (visit 1, V1), including questions about symptoms of restless legs syndrome (RLS), chronic fatigue syndrome (CFS), sleeping disorders, quality of life and symptoms like headaches, dyspnoea, dizziness, palpitations, pica and trophic changes in fingernails or hair. Results: We found a significant improvement in the severity of symptoms for RLS, fatigue and sleep quality (p < 0.001). Furthermore, a significant decrease in headaches, dyspnoea, dizziness and palpitations was reported (p < 0.05). There was no difference between the type of iron supplementation (intravenous versus oral) and clinical outcome data. Conclusion: Iron supplementation in iron-deficient blood donors may be an effective strategy to improve symptoms related to iron deficiency and the wellbeing of blood donors.

Prevalence of restless legs syndrome in blood donors

2010 ◽  
Vol 25 (10) ◽  
pp. 1451-1455 ◽  
Author(s):  
Vichaya Arunthari ◽  
Joseph Kaplan ◽  
Paul A. Fredrickson ◽  
Siong-Chi Lin ◽  
Pablo R. Castillo ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Blood Donors ◽  
Restless Legs

Iron status and chronic kidney disease predict restless legs syndrome in an older hospital population

2011 ◽  
Vol 12 (3) ◽  
pp. 295-301 ◽  
Author(s):  
Colin Quinn ◽  
Mateen Uzbeck ◽  
Imran Saleem ◽  
Paul Cotter ◽  
Javed Ali ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Restless Legs Syndrome ◽  
Iron Status ◽  
Restless Legs ◽  
Hospital Population

Iron Status and Restless Legs Syndrome in the Elderly

1994 ◽  
Vol 23 (3) ◽  
pp. 200-203 ◽  
Author(s):  
S. T. O'KEEFFE ◽  
K. GAVIN ◽  
J. N. LAVAN
Keyword(s):  
Restless Legs Syndrome ◽  
Iron Status ◽  
The Elderly ◽  
Restless Legs

The Role of Iron in Pediatric Restless Legs Syndrome and Periodic Limb Movements in Sleep

2017 ◽  
Vol 37 (04) ◽  
pp. 439-445 ◽  
Author(s):  
Barbara Felt ◽  
Tiffany Munzer
Keyword(s):  
Restless Legs Syndrome ◽  
Pediatric Patients ◽  
Randomized Clinical Trials ◽  
Iron Status ◽  
Current Evidence ◽  
Future Research ◽  
Symptom Improvement ◽  
Periodic Limb Movements ◽  
Limb Movements ◽  
Restless Legs

AbstractRestless legs syndrome (RLS) is a common and treatable neurologic condition in pediatric patients, with a prevalence as high as 2 to 3%. The diagnosis of RLS is made clinically based on an urge to move the legs accompanied by lower extremity discomfort that occurs during rest usually later in the day and is relieved by movement. Periodic limb movements in sleep (PLMS) can overlap with RLS, although PLMS also exists as a separate entity characterized by stereotyped movements of lower extremities in sleep. Both conditions may be highly debilitating and interfere with daily function notably in the areas of educational attainment and behavioral regulation. Iron deficiency has been implicated in the pathophysiology of both RLS and PLMS. Current evidence suggests that treatment of ferritin levels < 50 µg/L may be beneficial in improving pediatric RLS symptoms and comorbid conditions or daytime dysfunction associated with RLS. Areas for future research include (1) clarifying the ferritin or other iron status measure level which predicts iron treatment will provide symptom improvement in pediatric patients, and (2) randomized clinical trials using iron therapy to determine the degree and duration of treatment.

scholarly journals Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

2018 ◽  
Vol 45 ◽  
pp. 124-131 ◽  
Author(s):  
Maria Didriksen ◽  
Richard P. Allen ◽  
Brendan J. Burchell ◽  
Lise W. Thørner ◽  
Andreas S. Rigas ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Blood Donors ◽  
Restless Legs

Restless legs syndrome in Belgian repeat blood donors, no correlation with ferritin level

2016 ◽  
Vol 23 (2) ◽  
pp. 111-112 ◽  
Author(s):  
F. Crahay ◽  
D. Goossens ◽  
P. Gillet ◽  
A. Rapaille ◽  
M. Lambermont
Keyword(s):  
Restless Legs Syndrome ◽  
Blood Donors ◽  
Ferritin Level ◽  
Restless Legs
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